Clinical and immunological characteristics of HIV/syphilis co-infected patients following long-term antiretroviral treatment
Copyright © 2024 Wu, Lu, Song, Liu, Yang, Chen, Tang, Han, Lv, Cao and Li..
Objective: This study aims to analyze the efficacy of anti-syphilis treatment and the impact of syphilis events on HIV virology and immunology in HIV/syphilis co-infected patients on long-term antiretroviral therapy (ART) and to investigate the incidence and factors of syphilis recurrence/re-infection/serofast state. The insights derived from this investigation can potentially guide strategies for preventing and managing syphilis and AIDS.
Methods: A retrospective case-control study was conducted at the AIDS clinic of Peking Union Medical College Hospital from January 2003 to December 2022. The study involved 86 HIV/syphilis co-infected patients and 86 HIV mono-infected patients matched based on age, baseline CD4 + T cell counts, and viral load. We examined the clinical characteristics of HIV/syphilis co-infected patients, evaluated the efficacy of anti-syphilis treatment, and analyzed the dynamic changes in HIV virology and immunology. The Generalized Estimating Equations (GEE) model investigated the factors associated with HIV/syphilis co-infection and syphilis recurrence/reinfection/serofast state.
Results: Syphilis serofast state was observed in 11.6% (10/86) of HIV/syphilis co-infected patients after treatment, and 33.7% (29/86) had syphilis recurrence or re-infection. The overall effectiveness of syphilis treatment stood at 76.8% (63/82). Notably, the effectiveness of syphilis treatment displayed a significant correlation with baseline syphilis titers exceeding 1:128 (p = 0.003). Over the 10-year follow-up period on ART, the HLA-DR + CD8+/CD8 + % levels in the HIV/syphilis co-infected group were markedly higher than those in the HIV mono-infected group (p < 0.05). However, no significant differences were observed between the two groups regarding HIV viral load, CD4+ T cell counts, CD8+ T cell counts, CD4/CD8 ratio, and CD38 + CD8+/CD8 + % (p > 0.05). GEE analysis model revealed that elevated HLA-DR + CD8+/CD8 + % levels were associated with HIV/syphilis co-infection (OR = 1.026, 95% CI = 1.007-1.046; p = 0.007) and syphilis recurrence/reinfection/serofast state (OR = 1.036, 95% CI = 1.008-1.065; p = 0.012).
Conclusion: While HIV/syphilis co-infected patients typically receive adequate treatment, the incidence of syphilis recurrence and reinfection remain notably elevated. A heightened HLA-DR + CD8+/CD8+ % is a notable risk factor for HIV/syphilis co-infection and syphilis recurrence/reinfection/serofast state. Therefore, it is advisable to reinforce health education efforts and ensure regular follow-ups for people living with HIV undergoing ART to monitor syphilis infection or increased risk of syphilis infection.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2023 |
---|---|
Erschienen: |
2023 |
Enthalten in: |
Zur Gesamtaufnahme - volume:11 |
---|---|
Enthalten in: |
Frontiers in public health - 11(2023) vom: 15., Seite 1327896 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Wu, Yuanni [VerfasserIn] |
---|
Links: |
---|
Themen: |
AIDS |
---|
Anmerkungen: |
Date Completed 31.01.2024 Date Revised 31.01.2024 published: Electronic-eCollection Citation Status MEDLINE |
---|
doi: |
10.3389/fpubh.2023.1327896 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM367787741 |
---|
LEADER | 01000caa a22002652 4500 | ||
---|---|---|---|
001 | NLM367787741 | ||
003 | DE-627 | ||
005 | 20240131232155.0 | ||
007 | cr uuu---uuuuu | ||
008 | 240130s2023 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.3389/fpubh.2023.1327896 |2 doi | |
028 | 5 | 2 | |a pubmed24n1276.xml |
035 | |a (DE-627)NLM367787741 | ||
035 | |a (NLM)38288435 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Wu, Yuanni |e verfasserin |4 aut | |
245 | 1 | 0 | |a Clinical and immunological characteristics of HIV/syphilis co-infected patients following long-term antiretroviral treatment |
264 | 1 | |c 2023 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Completed 31.01.2024 | ||
500 | |a Date Revised 31.01.2024 | ||
500 | |a published: Electronic-eCollection | ||
500 | |a Citation Status MEDLINE | ||
520 | |a Copyright © 2024 Wu, Lu, Song, Liu, Yang, Chen, Tang, Han, Lv, Cao and Li. | ||
520 | |a Objective: This study aims to analyze the efficacy of anti-syphilis treatment and the impact of syphilis events on HIV virology and immunology in HIV/syphilis co-infected patients on long-term antiretroviral therapy (ART) and to investigate the incidence and factors of syphilis recurrence/re-infection/serofast state. The insights derived from this investigation can potentially guide strategies for preventing and managing syphilis and AIDS | ||
520 | |a Methods: A retrospective case-control study was conducted at the AIDS clinic of Peking Union Medical College Hospital from January 2003 to December 2022. The study involved 86 HIV/syphilis co-infected patients and 86 HIV mono-infected patients matched based on age, baseline CD4 + T cell counts, and viral load. We examined the clinical characteristics of HIV/syphilis co-infected patients, evaluated the efficacy of anti-syphilis treatment, and analyzed the dynamic changes in HIV virology and immunology. The Generalized Estimating Equations (GEE) model investigated the factors associated with HIV/syphilis co-infection and syphilis recurrence/reinfection/serofast state | ||
520 | |a Results: Syphilis serofast state was observed in 11.6% (10/86) of HIV/syphilis co-infected patients after treatment, and 33.7% (29/86) had syphilis recurrence or re-infection. The overall effectiveness of syphilis treatment stood at 76.8% (63/82). Notably, the effectiveness of syphilis treatment displayed a significant correlation with baseline syphilis titers exceeding 1:128 (p = 0.003). Over the 10-year follow-up period on ART, the HLA-DR + CD8+/CD8 + % levels in the HIV/syphilis co-infected group were markedly higher than those in the HIV mono-infected group (p < 0.05). However, no significant differences were observed between the two groups regarding HIV viral load, CD4+ T cell counts, CD8+ T cell counts, CD4/CD8 ratio, and CD38 + CD8+/CD8 + % (p > 0.05). GEE analysis model revealed that elevated HLA-DR + CD8+/CD8 + % levels were associated with HIV/syphilis co-infection (OR = 1.026, 95% CI = 1.007-1.046; p = 0.007) and syphilis recurrence/reinfection/serofast state (OR = 1.036, 95% CI = 1.008-1.065; p = 0.012) | ||
520 | |a Conclusion: While HIV/syphilis co-infected patients typically receive adequate treatment, the incidence of syphilis recurrence and reinfection remain notably elevated. A heightened HLA-DR + CD8+/CD8+ % is a notable risk factor for HIV/syphilis co-infection and syphilis recurrence/reinfection/serofast state. Therefore, it is advisable to reinforce health education efforts and ensure regular follow-ups for people living with HIV undergoing ART to monitor syphilis infection or increased risk of syphilis infection | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a AIDS | |
650 | 4 | |a HIV | |
650 | 4 | |a antiretroviral treatment | |
650 | 4 | |a immune recovery | |
650 | 4 | |a sexually transmitted disease | |
650 | 4 | |a syphilis | |
650 | 7 | |a HLA-DR Antigens |2 NLM | |
700 | 1 | |a Lu, Lianfeng |e verfasserin |4 aut | |
700 | 1 | |a Song, Xiaojing |e verfasserin |4 aut | |
700 | 1 | |a Liu, Xiaosheng |e verfasserin |4 aut | |
700 | 1 | |a Yang, Yang |e verfasserin |4 aut | |
700 | 1 | |a Chen, Ling |e verfasserin |4 aut | |
700 | 1 | |a Tang, Jia |e verfasserin |4 aut | |
700 | 1 | |a Han, Yang |e verfasserin |4 aut | |
700 | 1 | |a Lv, Wei |e verfasserin |4 aut | |
700 | 1 | |a Cao, Wei |e verfasserin |4 aut | |
700 | 1 | |a Li, Taisheng |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Frontiers in public health |d 2013 |g 11(2023) vom: 15., Seite 1327896 |w (DE-627)NLM23377548X |x 2296-2565 |7 nnns |
773 | 1 | 8 | |g volume:11 |g year:2023 |g day:15 |g pages:1327896 |
856 | 4 | 0 | |u http://dx.doi.org/10.3389/fpubh.2023.1327896 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 11 |j 2023 |b 15 |h 1327896 |