Blocked-flow vs. free-flow cyanoacrylate glue embolization : Histological differences in an in vivo rabbit renal artery model
Copyright © 2023 Société française de radiologie. Published by Elsevier Masson SAS. All rights reserved..
PURPOSE: The purpose of this in vivo animal study was to compare the acute histological effects on the arterial vessel wall of free-flow vs. blocked-flow embolization with metacryloxysulfolane-n‑butyl cyanoacrylate (MS-NBCA) in several concentrations.
MATERIALS AND METHODS: A total of 42 rabbit renal arteries were embolized using MS-NBCA mixed with ethiodized oil. The MS-NBCA concentration was 12.5%, 25%, or 50%. All mixtures were injected under both free-flow and blocked-flow conditions. The rabbits were euthanised 30 min after arterial embolization. Arterial-lumen distension, intimal inflammation and necrosis, peri‑arterial edema, and distality of MS-NBCA penetration were assessed histologically. Multivariable regression analyses were performed using a manual backward procedure, with linear, ordinal and logistic regression to search for factors associated with these outcomes RESULTS: Marked or severe dilatation was observed in 36 out of 42 arteries (86%) and marked or transmural intimal arteritis in all 42 arteries (42/42; 100%). Lumen dilatation caused focal vessel-wall flattening, which resulted in intimal necrosis. Multifocal necrosis extending from the intima to the media occurred in 23 out of 42 kidneys (55%) and peri‑arterial edema with multifocal vascular leakage in 19 out of 42 kidneys (45%). At multivariable analysis, blocked-flow MS-NBCA injection was associated with greater severity of vessel-wall lesions, including intimal arteritis (P = 0.003) and intimal necrosis (P = 0.014), compared to free-flow injection. Blocked-flow injection was also associated with peri‑arterial edema (P = 0.008) and greater distality of MS-NBCA penetration (P = 0.001).
CONCLUSION: Blocked-flow MS-NBCA injection during renal artery embolization is significantly associated with more acute arterial-wall damage and greater distality of glue penetration compared to free-flow injection in a rabbit model. These preliminary findings may have clinical implications, as blocked-flow injection is routinely used to treat specific vascular diseases or malformations in human.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2024 |
|---|---|
| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:105 |
|---|---|
| Enthalten in: |
Diagnostic and interventional imaging - 105(2024), 4 vom: 18. Apr., Seite 137-143 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Comby, Pierre-Olivier [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Animal model |
|---|
| Anmerkungen: |
Date Completed 02.04.2024 Date Revised 02.04.2024 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1016/j.diii.2023.10.003 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM367747545 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM367747545 | ||
| 003 | DE-627 | ||
| 005 | 20240403000134.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240129s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.diii.2023.10.003 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1361.xml |
| 035 | |a (DE-627)NLM367747545 | ||
| 035 | |a (NLM)38284342 | ||
| 035 | |a (PII)S2211-5684(23)00200-0 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Comby, Pierre-Olivier |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Blocked-flow vs. free-flow cyanoacrylate glue embolization |b Histological differences in an in vivo rabbit renal artery model |
| 264 | 1 | |c 2024 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 02.04.2024 | ||
| 500 | |a Date Revised 02.04.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2023 Société française de radiologie. Published by Elsevier Masson SAS. All rights reserved. | ||
| 520 | |a PURPOSE: The purpose of this in vivo animal study was to compare the acute histological effects on the arterial vessel wall of free-flow vs. blocked-flow embolization with metacryloxysulfolane-n‑butyl cyanoacrylate (MS-NBCA) in several concentrations | ||
| 520 | |a MATERIALS AND METHODS: A total of 42 rabbit renal arteries were embolized using MS-NBCA mixed with ethiodized oil. The MS-NBCA concentration was 12.5%, 25%, or 50%. All mixtures were injected under both free-flow and blocked-flow conditions. The rabbits were euthanised 30 min after arterial embolization. Arterial-lumen distension, intimal inflammation and necrosis, peri‑arterial edema, and distality of MS-NBCA penetration were assessed histologically. Multivariable regression analyses were performed using a manual backward procedure, with linear, ordinal and logistic regression to search for factors associated with these outcomes RESULTS: Marked or severe dilatation was observed in 36 out of 42 arteries (86%) and marked or transmural intimal arteritis in all 42 arteries (42/42; 100%). Lumen dilatation caused focal vessel-wall flattening, which resulted in intimal necrosis. Multifocal necrosis extending from the intima to the media occurred in 23 out of 42 kidneys (55%) and peri‑arterial edema with multifocal vascular leakage in 19 out of 42 kidneys (45%). At multivariable analysis, blocked-flow MS-NBCA injection was associated with greater severity of vessel-wall lesions, including intimal arteritis (P = 0.003) and intimal necrosis (P = 0.014), compared to free-flow injection. Blocked-flow injection was also associated with peri‑arterial edema (P = 0.008) and greater distality of MS-NBCA penetration (P = 0.001) | ||
| 520 | |a CONCLUSION: Blocked-flow MS-NBCA injection during renal artery embolization is significantly associated with more acute arterial-wall damage and greater distality of glue penetration compared to free-flow injection in a rabbit model. These preliminary findings may have clinical implications, as blocked-flow injection is routinely used to treat specific vascular diseases or malformations in human | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Animal model | |
| 650 | 4 | |a Blocked-flow injection | |
| 650 | 4 | |a Cyanoacrylate glue | |
| 650 | 4 | |a Free-flow injection | |
| 650 | 4 | |a Transcatheter embolization | |
| 650 | 7 | |a Cyanoacrylates |2 NLM | |
| 650 | 7 | |a Enbucrilate |2 NLM | |
| 650 | 7 | |a F8CEP82QNP |2 NLM | |
| 700 | 1 | |a Guillen, Kévin |e verfasserin |4 aut | |
| 700 | 1 | |a Chevallier, Olivier |e verfasserin |4 aut | |
| 700 | 1 | |a Couloumy, Emilie |e verfasserin |4 aut | |
| 700 | 1 | |a Dencausse, Anne |e verfasserin |4 aut | |
| 700 | 1 | |a Robert, Philippe |e verfasserin |4 aut | |
| 700 | 1 | |a Catoen, Sarah |e verfasserin |4 aut | |
| 700 | 1 | |a Salsac, Anne-Virginie |e verfasserin |4 aut | |
| 700 | 1 | |a Aho-Glele, Serge Ludwig |e verfasserin |4 aut | |
| 700 | 1 | |a Loffroy, Romaric |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Diagnostic and interventional imaging |d 2012 |g 105(2024), 4 vom: 18. Apr., Seite 137-143 |w (DE-627)NLM21623557X |x 2211-5684 |7 nnns |
| 773 | 1 | 8 | |g volume:105 |g year:2024 |g number:4 |g day:18 |g month:04 |g pages:137-143 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.diii.2023.10.003 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 105 |j 2024 |e 4 |b 18 |c 04 |h 137-143 | ||