Discovery of new dibenzodiazepine derivatives as antibacterials against intracellular bacteria
This journal is © The Royal Society of Chemistry..
The emergence and spread of multidrug-resistant bacteria underscore the critical need for novel antibacterial interventions. In our screening of 12 synthesized thienobenzodiazepines, pyridobenzodiazepines, and dibenzodiazepines, we successfully identified a small molecule compound SW33. Notably, SW33 demonstrated potent inhibitory activity against intracellular multidrug-resistant and fluoroquinolone-resistant strains of S. typhimurium in both macrophages and epithelial cells. Furthermore, SW33 was also effective against intramacrophagic Salmonella typhi, Yersinia enterocolitica, and Listeria monocytogenes. These significant findings suggest that SW33 possesses broad-spectrum activity against intracellular bacteria.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:15 |
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| Enthalten in: |
RSC medicinal chemistry - 15(2024), 1 vom: 25. Jan., Seite 283-292 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Chen, Ling-Han [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Revised 30.01.2024 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1039/d3md00418j |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a The emergence and spread of multidrug-resistant bacteria underscore the critical need for novel antibacterial interventions. In our screening of 12 synthesized thienobenzodiazepines, pyridobenzodiazepines, and dibenzodiazepines, we successfully identified a small molecule compound SW33. Notably, SW33 demonstrated potent inhibitory activity against intracellular multidrug-resistant and fluoroquinolone-resistant strains of S. typhimurium in both macrophages and epithelial cells. Furthermore, SW33 was also effective against intramacrophagic Salmonella typhi, Yersinia enterocolitica, and Listeria monocytogenes. These significant findings suggest that SW33 possesses broad-spectrum activity against intracellular bacteria | ||
| 650 | 4 | |a Journal Article | |
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| 700 | 1 | |a Lin, Hsueh-Chun |e verfasserin |4 aut | |
| 700 | 1 | |a Yang, Fan-Wei |e verfasserin |4 aut | |
| 700 | 1 | |a Liao, Hsiao-Wei |e verfasserin |4 aut | |
| 700 | 1 | |a Shiau, Chung-Wai |e verfasserin |4 aut | |
| 700 | 1 | |a Chiu, Hao-Chieh |e verfasserin |4 aut | |
| 700 | 1 | |a Su, Jung-Chen |e verfasserin |4 aut | |
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