Prospective cohort study of vitamin D deficiency in pregnancy : Prevalence and limited effectiveness of 1000 IU vitamin D supplementation
BACKGROUND: Vitamin D deficiency is highly prevalent worldwide among pregnant women. Although vitamin D supplementation is effective in improving vitamin D status, the safety and optimal dosing of vitamin D supplementation during pregnancy remain less well understood.
OBJECTIVE: This study aimed to investigate the prevalence of vitamin D deficiency among pregnant women and evaluate the effectiveness of vitamin D supplementation in improving vitamin D status during pregnancy.
DESIGN: This prospective cohort study assessed the impact of a 16-week daily vitamin D supplementation 1000 IU regimen on vitamin D status among pregnant women.
METHODS: A total of 365 pregnant women were recruited, and their baseline total circulating 25-hydroxy vitamin D concentrations were measured. Of these, 249 participants completed the study, which involved oral daily supplementation with 1000 IU of vitamin D and a repeat of total circulating 25-hydroxy vitamin D concentrations after 16 weeks.
RESULTS: The study found that 57.7% of the participants had vitamin D deficiency, consistent with the rates reported in other studies. However, vitamin D supplementation at a dose of 1000 IU had a small effect size and was not clinically significant. However, 67% of participants with vitamin D deficiency remained deficient; among participants initially with vitamin D insufficiency, 30% became deficient. Moreover, 26.5% of individuals with sufficient vitamin D status at 12 weeks showed insufficient levels by 28 weeks.
CONCLUSION: Vitamin D deficiency is widespread among pregnant women, and vitamin D supplementation at a daily dose of 1000 IU may not adequately address this problem. Although the study has limitations, its results align with previous research and may apply to other populations with a high prevalence of vitamin D deficiency during pregnancy. Further research is necessary to determine the most effective approach for addressing prenatal vitamin D deficiency.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:20 |
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| Enthalten in: |
Women's health (London, England) - 20(2024) vom: 31. Jan., Seite 17455057231222404 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Abdelmageed, Rasha Mohammed [VerfasserIn] |
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| Links: |
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| Themen: |
1406-16-2 |
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| Anmerkungen: |
Date Completed 30.01.2024 Date Revised 01.02.2024 published: Print Citation Status MEDLINE |
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| doi: |
10.1177/17455057231222404 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
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| 100 | 1 | |a Abdelmageed, Rasha Mohammed |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Prospective cohort study of vitamin D deficiency in pregnancy |b Prevalence and limited effectiveness of 1000 IU vitamin D supplementation |
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| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a BACKGROUND: Vitamin D deficiency is highly prevalent worldwide among pregnant women. Although vitamin D supplementation is effective in improving vitamin D status, the safety and optimal dosing of vitamin D supplementation during pregnancy remain less well understood | ||
| 520 | |a OBJECTIVE: This study aimed to investigate the prevalence of vitamin D deficiency among pregnant women and evaluate the effectiveness of vitamin D supplementation in improving vitamin D status during pregnancy | ||
| 520 | |a DESIGN: This prospective cohort study assessed the impact of a 16-week daily vitamin D supplementation 1000 IU regimen on vitamin D status among pregnant women | ||
| 520 | |a METHODS: A total of 365 pregnant women were recruited, and their baseline total circulating 25-hydroxy vitamin D concentrations were measured. Of these, 249 participants completed the study, which involved oral daily supplementation with 1000 IU of vitamin D and a repeat of total circulating 25-hydroxy vitamin D concentrations after 16 weeks | ||
| 520 | |a RESULTS: The study found that 57.7% of the participants had vitamin D deficiency, consistent with the rates reported in other studies. However, vitamin D supplementation at a dose of 1000 IU had a small effect size and was not clinically significant. However, 67% of participants with vitamin D deficiency remained deficient; among participants initially with vitamin D insufficiency, 30% became deficient. Moreover, 26.5% of individuals with sufficient vitamin D status at 12 weeks showed insufficient levels by 28 weeks | ||
| 520 | |a CONCLUSION: Vitamin D deficiency is widespread among pregnant women, and vitamin D supplementation at a daily dose of 1000 IU may not adequately address this problem. Although the study has limitations, its results align with previous research and may apply to other populations with a high prevalence of vitamin D deficiency during pregnancy. Further research is necessary to determine the most effective approach for addressing prenatal vitamin D deficiency | ||
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| 700 | 1 | |a Hussein, Suha Majeed Mohammed |e verfasserin |4 aut | |
| 700 | 1 | |a Anamangadan, Shamil Mohamed |e verfasserin |4 aut | |
| 700 | 1 | |a Abdullah, Rola Walid Mahmoud |e verfasserin |4 aut | |
| 700 | 1 | |a Rauf, Lubna |e verfasserin |4 aut | |
| 700 | 1 | |a AlFehaidi, AlAnoud Saleh |e verfasserin |4 aut | |
| 700 | 1 | |a Hamed, Ehab |e verfasserin |4 aut | |
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