Potential Neuroprotective Role of Neurotrophin in Traumatic Brain Injury
Copyright© Bentham Science Publishers; For any queries, please email at epubbenthamscience.net..
Traumatic brain injury (TBI) is a major global health issue that affects millions of people every year. It is caused by any form of external force, resulting in temporary or permanent impairments in the brain. The pathophysiological process following TBI usually involves excitotoxicity, mitochondrial dysfunction, oxidative stress, inflammation, ischemia, and apoptotic cell death. It is challenging to find treatment for TBI due to its heterogeneous nature, and no therapeutic interventions have been approved thus far. Neurotrophins may represent an alternative approach for TBI treatment because they influence various functional activities in the brain. The present review highlights recent studies on neurotrophins shown to possess neuroprotective roles in TBI. Neurotrophins, specifically brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) have demonstrated reduced neuronal death, alleviated neuroinflammatory responses and improved neurological functions following TBI via their immunomodulatory, anti-inflammatory and antioxidant properties. Further studies are required to ensure the efficacy and safety of neurotrophins to be used as TBI treatment in clinical settings.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2024 |
---|---|
Erschienen: |
2024 |
Enthalten in: |
Zur Gesamtaufnahme - year:2024 |
---|---|
Enthalten in: |
CNS & neurological disorders drug targets - (2024) vom: 25. Jan. |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Yap, Rei Shian [VerfasserIn] |
---|
Links: |
---|
Themen: |
Biomaterials. |
---|
Anmerkungen: |
Date Revised 27.01.2024 published: Print-Electronic Citation Status Publisher |
---|
doi: |
10.2174/0118715273289222231219094225 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM367701723 |
---|
LEADER | 01000naa a22002652 4500 | ||
---|---|---|---|
001 | NLM367701723 | ||
003 | DE-627 | ||
005 | 20240127232022.0 | ||
007 | cr uuu---uuuuu | ||
008 | 240127s2024 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.2174/0118715273289222231219094225 |2 doi | |
028 | 5 | 2 | |a pubmed24n1272.xml |
035 | |a (DE-627)NLM367701723 | ||
035 | |a (NLM)38279761 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Yap, Rei Shian |e verfasserin |4 aut | |
245 | 1 | 0 | |a Potential Neuroprotective Role of Neurotrophin in Traumatic Brain Injury |
264 | 1 | |c 2024 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Revised 27.01.2024 | ||
500 | |a published: Print-Electronic | ||
500 | |a Citation Status Publisher | ||
520 | |a Copyright© Bentham Science Publishers; For any queries, please email at epubbenthamscience.net. | ||
520 | |a Traumatic brain injury (TBI) is a major global health issue that affects millions of people every year. It is caused by any form of external force, resulting in temporary or permanent impairments in the brain. The pathophysiological process following TBI usually involves excitotoxicity, mitochondrial dysfunction, oxidative stress, inflammation, ischemia, and apoptotic cell death. It is challenging to find treatment for TBI due to its heterogeneous nature, and no therapeutic interventions have been approved thus far. Neurotrophins may represent an alternative approach for TBI treatment because they influence various functional activities in the brain. The present review highlights recent studies on neurotrophins shown to possess neuroprotective roles in TBI. Neurotrophins, specifically brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) have demonstrated reduced neuronal death, alleviated neuroinflammatory responses and improved neurological functions following TBI via their immunomodulatory, anti-inflammatory and antioxidant properties. Further studies are required to ensure the efficacy and safety of neurotrophins to be used as TBI treatment in clinical settings | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Traumatic brain injury | |
650 | 4 | |a biomaterials. | |
650 | 4 | |a brain-derived neurotrophic factor | |
650 | 4 | |a cell-based therapy | |
650 | 4 | |a nanoparticles | |
650 | 4 | |a nerve growth factor | |
650 | 4 | |a neurotrophin | |
700 | 1 | |a Kumar, Jaya |e verfasserin |4 aut | |
700 | 1 | |a Teoh, Seong Lin |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t CNS & neurological disorders drug targets |d 2006 |g (2024) vom: 25. Jan. |w (DE-627)NLM161975518 |x 1996-3181 |7 nnns |
773 | 1 | 8 | |g year:2024 |g day:25 |g month:01 |
856 | 4 | 0 | |u http://dx.doi.org/10.2174/0118715273289222231219094225 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |j 2024 |b 25 |c 01 |