A Review on Synthetic Thiazole Derivatives as an Antimalarial Agent
Copyright© Bentham Science Publishers; For any queries, please email at epubbenthamscience.net..
BACKGROUND: Thiazole is a widely studied core structure in heterocyclic chemistry and has proven to be a valuable scaffold in medicinal chemistry. The presence of thiazole in both naturally occurring and synthetic pharmacologically active compounds demonstrates the adaptability of these derivatives.
METHODS: The current study attempted to review and compile the contributions of numerous researchers over the last 20 years to the medicinal importance of these scaffolds, with a primary focus on antimalarial activity. The review is based on an extensive search of PubMed, Google Scholar, Elsevier, and other renowned journal sites for a thorough literature survey involving various research and review articles.
RESULTS: A comprehensive review of the antimalarial activity of the thiazole scaffold revealed potential therapeutic targets in Plasmodium species. Furthermore, the correlation of structure-activity-relationship (SAR) studies from various articles suggests that the thiazole ring has therapeutic potential.
CONCLUSION: This article intends to point researchers in the right direction for developing potential thiazole-based compounds as antimalarial agents in the future.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2024 |
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| Enthalten in: |
Current drug discovery technologies - (2024) vom: 24. Jan. |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Kalita, Tutumoni [VerfasserIn] |
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| Links: |
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| Themen: |
Anti-parasitic. |
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| Anmerkungen: |
Date Revised 27.01.2024 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.2174/0115701638276379231223101625 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM367701332 |
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| 520 | |a Copyright© Bentham Science Publishers; For any queries, please email at epubbenthamscience.net. | ||
| 520 | |a BACKGROUND: Thiazole is a widely studied core structure in heterocyclic chemistry and has proven to be a valuable scaffold in medicinal chemistry. The presence of thiazole in both naturally occurring and synthetic pharmacologically active compounds demonstrates the adaptability of these derivatives | ||
| 520 | |a METHODS: The current study attempted to review and compile the contributions of numerous researchers over the last 20 years to the medicinal importance of these scaffolds, with a primary focus on antimalarial activity. The review is based on an extensive search of PubMed, Google Scholar, Elsevier, and other renowned journal sites for a thorough literature survey involving various research and review articles | ||
| 520 | |a RESULTS: A comprehensive review of the antimalarial activity of the thiazole scaffold revealed potential therapeutic targets in Plasmodium species. Furthermore, the correlation of structure-activity-relationship (SAR) studies from various articles suggests that the thiazole ring has therapeutic potential | ||
| 520 | |a CONCLUSION: This article intends to point researchers in the right direction for developing potential thiazole-based compounds as antimalarial agents in the future | ||
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| 650 | 4 | |a Antimalarial activity | |
| 650 | 4 | |a Biological activity | |
| 650 | 4 | |a Plasmodium falciparum | |
| 650 | 4 | |a Potential lead | |
| 650 | 4 | |a Thiazole derivatives | |
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| 700 | 1 | |a Shakya, Anshul |e verfasserin |4 aut | |
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