Antihypertensive and ACE-2 Inhibitory Effects of Daphne gnidium in Rats
Copyright© Bentham Science Publishers; For any queries, please email at epubbenthamscience.net..
AIMS: The antihypertensive activity of Daphne gnidium was tested.
BACKGROUND: Daphne gnidium (Thymelaeaceae) is used against hypertension.
OBJECTIVE: The antihypertensive effect of Daphne gnidium was evaluated in this study.
METHODS: The effect of Daphne gnidium aqueous extract (DGAE, 100 and 180 mg/kg) on blood pressure was evaluated in rats. In addition, the vasorelaxant effect of this extract was also tested.
RESULTS: DGAE lowered blood pressure in hypertensive rats and exhibited vasorelaxant activity. In addition, cumulative concentrations of DGAE induced vasodilatation through receptoractivated calcium channels (ROCCs) without affecting ACE-2.
CONCLUSION: The aqueous extract of Daphne gnidium exhibits antihypertensive activity and induces vasodilatation via the inhibition of Ca2+ entry.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2024 |
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| Enthalten in: |
Cardiovascular & hematological agents in medicinal chemistry - (2024) vom: 24. Jan. |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Bouadid, Ismail [VerfasserIn] |
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| Links: |
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| Themen: |
ACE-2. |
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| Anmerkungen: |
Date Revised 27.01.2024 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.2174/0118715257251651231212045407 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM367701189 |
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| 100 | 1 | |a Bouadid, Ismail |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Antihypertensive and ACE-2 Inhibitory Effects of Daphne gnidium in Rats |
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| 500 | |a Date Revised 27.01.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status Publisher | ||
| 520 | |a Copyright© Bentham Science Publishers; For any queries, please email at epubbenthamscience.net. | ||
| 520 | |a AIMS: The antihypertensive activity of Daphne gnidium was tested | ||
| 520 | |a BACKGROUND: Daphne gnidium (Thymelaeaceae) is used against hypertension | ||
| 520 | |a OBJECTIVE: The antihypertensive effect of Daphne gnidium was evaluated in this study | ||
| 520 | |a METHODS: The effect of Daphne gnidium aqueous extract (DGAE, 100 and 180 mg/kg) on blood pressure was evaluated in rats. In addition, the vasorelaxant effect of this extract was also tested | ||
| 520 | |a RESULTS: DGAE lowered blood pressure in hypertensive rats and exhibited vasorelaxant activity. In addition, cumulative concentrations of DGAE induced vasodilatation through receptoractivated calcium channels (ROCCs) without affecting ACE-2 | ||
| 520 | |a CONCLUSION: The aqueous extract of Daphne gnidium exhibits antihypertensive activity and induces vasodilatation via the inhibition of Ca2+ entry | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a ACE-2. | |
| 650 | 4 | |a Daphne gnidium (L.) | |
| 650 | 4 | |a Hypertension | |
| 650 | 4 | |a Vasorelaxant | |
| 650 | 4 | |a antihypertensive | |
| 650 | 4 | |a receptor-activated calcium channels (ROCCs) | |
| 700 | 1 | |a Qabouche, Adil |e verfasserin |4 aut | |
| 700 | 1 | |a Eddouks, Mohamed |e verfasserin |4 aut | |
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