Augmenting Neutrophil Extracellular Traps with Carbonized Polymer Dots : A Potential Treatment for Bacterial Sepsis
© 2024 Wiley-VCH GmbH..
Sepsis is a life-threatening condition that can progress to septic shock as the body's extreme response to pathogenesis damages its own vital organs. Staphylococcus aureus (S. aureus) accounts for 50% of nosocomial infections, which are clinically treated with antibiotics. However, methicillin-resistant strains (MRSA) have emerged and can withstand harsh antibiotic treatment. To address this problem, curcumin (CCM) is employed to prepare carbonized polymer dots (CPDs) through mild pyrolysis. Contrary to curcumin, the as-formed CCM-CPDs are highly biocompatible and soluble in aqueous solution. Most importantly, the CCM-CPDs induce the release of neutrophil extracellular traps (NETs) from the neutrophils, which entrap and eliminate microbes. In an MRSA-induced septic mouse model, it is observed that CCM-CPDs efficiently suppress bacterial colonization. Moreover, the intrinsic antioxidative, anti-inflammatory, and anticoagulation activities resulting from the preserved functional groups of the precursor molecule on the CCM-CPDs prevent progression to severe sepsis. As a result, infected mice treated with CCM-CPDs show a significant decrease in mortality even through oral administration. Histological staining indicates negligible organ damage in the MRSA-infected mice treated with CCM-CPDs. It is believed that the in vivo studies presented herein demonstrate that multifunctional therapeutic CPDs hold great potential against life-threatening infectious diseases.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2024 |
|---|---|
| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2024 |
|---|---|
| Enthalten in: |
Small (Weinheim an der Bergstrasse, Germany) - (2024) vom: 26. Jan., Seite e2307210 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Lin, Chin-Jung [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Antibiotic resistance |
|---|
| Anmerkungen: |
Date Revised 22.02.2024 published: Print-Electronic Citation Status Publisher |
|---|
| doi: |
10.1002/smll.202307210 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM367700158 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM367700158 | ||
| 003 | DE-627 | ||
| 005 | 20240222232420.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240127s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1002/smll.202307210 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1302.xml |
| 035 | |a (DE-627)NLM367700158 | ||
| 035 | |a (NLM)38279606 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Lin, Chin-Jung |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Augmenting Neutrophil Extracellular Traps with Carbonized Polymer Dots |b A Potential Treatment for Bacterial Sepsis |
| 264 | 1 | |c 2024 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Revised 22.02.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status Publisher | ||
| 520 | |a © 2024 Wiley-VCH GmbH. | ||
| 520 | |a Sepsis is a life-threatening condition that can progress to septic shock as the body's extreme response to pathogenesis damages its own vital organs. Staphylococcus aureus (S. aureus) accounts for 50% of nosocomial infections, which are clinically treated with antibiotics. However, methicillin-resistant strains (MRSA) have emerged and can withstand harsh antibiotic treatment. To address this problem, curcumin (CCM) is employed to prepare carbonized polymer dots (CPDs) through mild pyrolysis. Contrary to curcumin, the as-formed CCM-CPDs are highly biocompatible and soluble in aqueous solution. Most importantly, the CCM-CPDs induce the release of neutrophil extracellular traps (NETs) from the neutrophils, which entrap and eliminate microbes. In an MRSA-induced septic mouse model, it is observed that CCM-CPDs efficiently suppress bacterial colonization. Moreover, the intrinsic antioxidative, anti-inflammatory, and anticoagulation activities resulting from the preserved functional groups of the precursor molecule on the CCM-CPDs prevent progression to severe sepsis. As a result, infected mice treated with CCM-CPDs show a significant decrease in mortality even through oral administration. Histological staining indicates negligible organ damage in the MRSA-infected mice treated with CCM-CPDs. It is believed that the in vivo studies presented herein demonstrate that multifunctional therapeutic CPDs hold great potential against life-threatening infectious diseases | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a antibiotic resistance | |
| 650 | 4 | |a bacterial sepsis | |
| 650 | 4 | |a carbonized polymer dots | |
| 650 | 4 | |a curcumin | |
| 650 | 4 | |a neutrophil extracellular traps | |
| 700 | 1 | |a Hwang, Tsong-Long |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Robert Y L |e verfasserin |4 aut | |
| 700 | 1 | |a Nain, Amit |e verfasserin |4 aut | |
| 700 | 1 | |a Shih, Ren-Hong |e verfasserin |4 aut | |
| 700 | 1 | |a Chang, Lung |e verfasserin |4 aut | |
| 700 | 1 | |a Lin, Han-Jia |e verfasserin |4 aut | |
| 700 | 1 | |a Harroun, Scott G |e verfasserin |4 aut | |
| 700 | 1 | |a Chang, Huan-Tsung |e verfasserin |4 aut | |
| 700 | 1 | |a Huang, Chih-Ching |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Small (Weinheim an der Bergstrasse, Germany) |d 2005 |g (2024) vom: 26. Jan., Seite e2307210 |w (DE-627)NLM167400452 |x 1613-6829 |7 nnns |
| 773 | 1 | 8 | |g year:2024 |g day:26 |g month:01 |g pages:e2307210 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1002/smll.202307210 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |j 2024 |b 26 |c 01 |h e2307210 | ||