RNA Analysis of Circulating Leukocytes in Patients with Alzheimer's Disease
Background: One of the key symptoms of Alzheimer's disease (AD) is the impairment of short-term memory. Hippocampal neurogenesis is essential for short-term memory and is known to decrease in patients with AD. Impaired short-term memory and impaired neurogenesis are observed in aged mice alongside changes in RNA expression of gap junction and metabolism-related genes in circulating leukocytes. Moreover, after penetrating the blood-brain barrier via the SDF1/CXCR4 axis, circulating leukocytes directly interact with hippocampal neuronal stem cells via gap junctions.
Objective: Evaluation of RNA expression profiles in circulating leukocytes in patients with AD.
Methods: Patients with AD (MMSE≧23, n = 10) and age-matched controls (MMSE≧28, n = 10) were enrolled into this study. RNA expression profiles of gap junction and metabolism-related genes in circulating leukocytes were compared between the groups (jRCT: 1050210166).
Results: The ratios of gap junction and metabolism-related genes were significantly different between patients with AD and age-matched controls. However, due to large inter-individual variations, there were no statistically significant differences in the level of single RNA expression between these groups.
Conclusions: Our findings suggest a potential connection between the presence of circulating leukocytes and the process of hippocampal neurogenesis in individuals with AD. Analyzing RNA in circulating leukocytes holds promise as a means to offer novel insights into the pathology of AD, distinct from conventional markers.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:97 |
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| Enthalten in: |
Journal of Alzheimer's disease : JAD - 97(2024), 4 vom: 01., Seite 1673-1683 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Okinaka, Yuka [VerfasserIn] |
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| Links: |
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| Themen: |
Alzheimer’s disease |
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| Anmerkungen: |
Date Completed 19.02.2024 Date Revised 27.02.2024 published: Print Citation Status MEDLINE |
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| doi: |
10.3233/JAD-230874 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM367677040 |
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| 245 | 1 | 0 | |a RNA Analysis of Circulating Leukocytes in Patients with Alzheimer's Disease |
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| 500 | |a Date Revised 27.02.2024 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Background: One of the key symptoms of Alzheimer's disease (AD) is the impairment of short-term memory. Hippocampal neurogenesis is essential for short-term memory and is known to decrease in patients with AD. Impaired short-term memory and impaired neurogenesis are observed in aged mice alongside changes in RNA expression of gap junction and metabolism-related genes in circulating leukocytes. Moreover, after penetrating the blood-brain barrier via the SDF1/CXCR4 axis, circulating leukocytes directly interact with hippocampal neuronal stem cells via gap junctions | ||
| 520 | |a Objective: Evaluation of RNA expression profiles in circulating leukocytes in patients with AD | ||
| 520 | |a Methods: Patients with AD (MMSE≧23, n = 10) and age-matched controls (MMSE≧28, n = 10) were enrolled into this study. RNA expression profiles of gap junction and metabolism-related genes in circulating leukocytes were compared between the groups (jRCT: 1050210166) | ||
| 520 | |a Results: The ratios of gap junction and metabolism-related genes were significantly different between patients with AD and age-matched controls. However, due to large inter-individual variations, there were no statistically significant differences in the level of single RNA expression between these groups | ||
| 520 | |a Conclusions: Our findings suggest a potential connection between the presence of circulating leukocytes and the process of hippocampal neurogenesis in individuals with AD. Analyzing RNA in circulating leukocytes holds promise as a means to offer novel insights into the pathology of AD, distinct from conventional markers | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Alzheimer’s disease | |
| 650 | 4 | |a circulating leukocyte | |
| 650 | 4 | |a gap junction | |
| 650 | 4 | |a novel biomarker | |
| 650 | 4 | |a quantitative PCR | |
| 650 | 4 | |a white blood cells | |
| 700 | 1 | |a Shinagawa, Yoshiyuki |e verfasserin |4 aut | |
| 700 | 1 | |a Claussen, Carsten |e verfasserin |4 aut | |
| 700 | 1 | |a Gul, Sheraz |e verfasserin |4 aut | |
| 700 | 1 | |a Matsui, Ikuko |e verfasserin |4 aut | |
| 700 | 1 | |a Matsui, Yutaka |e verfasserin |4 aut | |
| 700 | 1 | |a Taguchi, Akihiko |e verfasserin |4 aut | |
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