Dynamics of Anti-SARS-CoV-2 IgA and IgG Responses and Their Protective Effect against Fatal Disease after Booster COVID-19 Vaccination
During the post-coronavirus disease (COVID-19) era, a primary question is whether booster vaccination is effective against severe COVID-19 and should be recommended, particularly to individuals at high risk for severe disease (i.e., the elderly or those with additional severe comorbidities). From December 2020 to February 2023, a cohort study was conducted to estimate IgG and IgA immunogenicity and the dynamics of booster mono- and bivalent COVID-19 mRNA vaccines in 260 individuals (male/female: 114/146, median age: 68 years, interquartile range (IQR) = 31) who initially received either mRNA (218) or adenovirus-vector-based vaccines (42). Participants were followed until the 90th day after the third booster dose. Our cohort study indicated a beneficial effect of booster vaccination on the magnitude of IgG and IgA severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies. We found that second and third booster doses were more protective than one against fatal disease (p = 0.031, OR 0.08). In conclusion, booster COVID-19 vaccination should be strongly recommended, especially to individuals at high risk for severe/fatal disease.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2023 |
---|---|
Erschienen: |
2023 |
Enthalten in: |
Zur Gesamtaufnahme - volume:12 |
---|---|
Enthalten in: |
Vaccines - 12(2023), 1 vom: 21. Dez. |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Speletas, Matthaios [VerfasserIn] |
---|
Links: |
---|
Themen: |
Anti-SARS-CoV-2 IgA responses |
---|
Anmerkungen: |
Date Revised 29.01.2024 published: Electronic Citation Status PubMed-not-MEDLINE |
---|
doi: |
10.3390/vaccines12010012 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM367670801 |
---|
LEADER | 01000caa a22002652 4500 | ||
---|---|---|---|
001 | NLM367670801 | ||
003 | DE-627 | ||
005 | 20240129232213.0 | ||
007 | cr uuu---uuuuu | ||
008 | 240126s2023 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.3390/vaccines12010012 |2 doi | |
028 | 5 | 2 | |a pubmed24n1274.xml |
035 | |a (DE-627)NLM367670801 | ||
035 | |a (NLM)38276671 | ||
035 | |a (PII)12 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Speletas, Matthaios |e verfasserin |4 aut | |
245 | 1 | 0 | |a Dynamics of Anti-SARS-CoV-2 IgA and IgG Responses and Their Protective Effect against Fatal Disease after Booster COVID-19 Vaccination |
264 | 1 | |c 2023 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Revised 29.01.2024 | ||
500 | |a published: Electronic | ||
500 | |a Citation Status PubMed-not-MEDLINE | ||
520 | |a During the post-coronavirus disease (COVID-19) era, a primary question is whether booster vaccination is effective against severe COVID-19 and should be recommended, particularly to individuals at high risk for severe disease (i.e., the elderly or those with additional severe comorbidities). From December 2020 to February 2023, a cohort study was conducted to estimate IgG and IgA immunogenicity and the dynamics of booster mono- and bivalent COVID-19 mRNA vaccines in 260 individuals (male/female: 114/146, median age: 68 years, interquartile range (IQR) = 31) who initially received either mRNA (218) or adenovirus-vector-based vaccines (42). Participants were followed until the 90th day after the third booster dose. Our cohort study indicated a beneficial effect of booster vaccination on the magnitude of IgG and IgA severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies. We found that second and third booster doses were more protective than one against fatal disease (p = 0.031, OR 0.08). In conclusion, booster COVID-19 vaccination should be strongly recommended, especially to individuals at high risk for severe/fatal disease | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a COVID-19 mRNA vaccination | |
650 | 4 | |a SARS-CoV-2 | |
650 | 4 | |a anti-SARS-CoV-2 IgA responses | |
650 | 4 | |a anti-SARS-CoV-2 IgG responses | |
650 | 4 | |a booster vaccination | |
700 | 1 | |a Voulgaridi, Ioanna |e verfasserin |4 aut | |
700 | 1 | |a Bogogiannidou, Zacharoula |e verfasserin |4 aut | |
700 | 1 | |a Sarrou, Styliani |e verfasserin |4 aut | |
700 | 1 | |a Kyritsi, Maria A |e verfasserin |4 aut | |
700 | 1 | |a Theodoridou, Aikaterini |e verfasserin |4 aut | |
700 | 1 | |a Dadouli, Katerina |e verfasserin |4 aut | |
700 | 1 | |a Matziri, Alexia |e verfasserin |4 aut | |
700 | 1 | |a Vontas, Alexandros |e verfasserin |4 aut | |
700 | 1 | |a Pappa, Dimitra |e verfasserin |4 aut | |
700 | 1 | |a Konstantinou, Adamos-Konstantinos |e verfasserin |4 aut | |
700 | 1 | |a Tsigalou, Christina |e verfasserin |4 aut | |
700 | 1 | |a Kalala, Fani |e verfasserin |4 aut | |
700 | 1 | |a Mouchtouri, Varvara A |e verfasserin |4 aut | |
700 | 1 | |a Hadjichristodoulou, Christos |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Vaccines |d 2012 |g 12(2023), 1 vom: 21. Dez. |w (DE-627)NLM239212347 |x 2076-393X |7 nnns |
773 | 1 | 8 | |g volume:12 |g year:2023 |g number:1 |g day:21 |g month:12 |
856 | 4 | 0 | |u http://dx.doi.org/10.3390/vaccines12010012 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 12 |j 2023 |e 1 |b 21 |c 12 |