Effectiveness of Upadacitinib for Patients With Acute Severe Ulcerative Colitis : A Multicenter Experience
Copyright © 2024 by The American College of Gastroenterology..
INTRODUCTION: A significant proportion of patients with acute severe ulcerative colitis (ASUC) require colectomy.
METHODS: Patients with ASUC treated with upadacitinib and intravenous corticosteroids at 5 hospitals are presented. The primary outcome was 90-day colectomy rate. Secondary outcomes included frequency of steroid-free clinical remission, adverse events, and all-cause readmissions.
RESULTS: Of the 25 patients with ASUC treated with upadacitinib, 6 (24%) patients underwent colectomy, 15 (83%) of the 18 patients with available data and who did not undergo colectomy experienced steroid-free clinical remission (1 patient did not have complete data), 1 (4%) patient experienced a venous thromboembolic event, while 5 (20%) patients were readmitted.
DISCUSSION: Upadacitinib along with intravenous corticosteroids may be an effective treatment for ASUC.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2024 |
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| Enthalten in: |
The American journal of gastroenterology - (2024) vom: 27. März |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Berinstein, Jeffrey A [VerfasserIn] |
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| Links: |
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Date Revised 26.03.2024 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.14309/ajg.0000000000002674 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM367656663 |
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| 100 | 1 | |a Berinstein, Jeffrey A |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Effectiveness of Upadacitinib for Patients With Acute Severe Ulcerative Colitis |b A Multicenter Experience |
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| 520 | |a Copyright © 2024 by The American College of Gastroenterology. | ||
| 520 | |a INTRODUCTION: A significant proportion of patients with acute severe ulcerative colitis (ASUC) require colectomy | ||
| 520 | |a METHODS: Patients with ASUC treated with upadacitinib and intravenous corticosteroids at 5 hospitals are presented. The primary outcome was 90-day colectomy rate. Secondary outcomes included frequency of steroid-free clinical remission, adverse events, and all-cause readmissions | ||
| 520 | |a RESULTS: Of the 25 patients with ASUC treated with upadacitinib, 6 (24%) patients underwent colectomy, 15 (83%) of the 18 patients with available data and who did not undergo colectomy experienced steroid-free clinical remission (1 patient did not have complete data), 1 (4%) patient experienced a venous thromboembolic event, while 5 (20%) patients were readmitted | ||
| 520 | |a DISCUSSION: Upadacitinib along with intravenous corticosteroids may be an effective treatment for ASUC | ||
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| 700 | 1 | |a Dolinger, Michael |e verfasserin |4 aut | |
| 700 | 1 | |a Barrett, Terrence A |e verfasserin |4 aut | |
| 700 | 1 | |a Ahmed, Waseem |e verfasserin |4 aut | |
| 700 | 1 | |a Click, Ben |e verfasserin |4 aut | |
| 700 | 1 | |a Steiner, Calen A |e verfasserin |4 aut | |
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