Quantifying Sharpness and Nonlinearity in Neonatal Seizure Dynamics
Copyright © 2024 Chien-Hung Yeh et al..
The integration of multiple electrophysiological biomarkers is crucial for monitoring neonatal seizure dynamics. The present study aimed to characterize the temporal dynamics of neonatal seizures by analyzing intrinsic waveforms of epileptic electroencephalogram (EEG) signals. We proposed a complementary set of methods considering envelope power, focal sharpness changes, and nonlinear patterns of EEG signals of 79 neonates with seizures. Features derived from EEG signals were used as input to the machine learning classifier. All three characteristics were significantly elevated during seizure events, as agreed upon by all viewers (P < 0.0001). Envelope power was elevated in the entire seizure period, and the degree of nonlinearity rose at the termination of a seizure event. Epileptic sharpness effectively characterizes an entire seizure event, complementing the role of envelope power in identifying its onset. However, the degree of nonlinearity showed superior discriminability for the termination of a seizure event. The proposed computational methods for intrinsic sharp or nonlinear EEG patterns evolving during neonatal seizure could share some features with envelope power. Current findings may be helpful in developing strategies to improve neonatal seizure monitoring.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:5 |
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| Enthalten in: |
Cyborg and bionic systems (Washington, D.C.) - 5(2024) vom: 21., Seite 0076 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Yeh, Chien-Hung [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Revised 27.01.2024 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
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| doi: |
10.34133/cbsystems.0076 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM367651319 |
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| 520 | |a The integration of multiple electrophysiological biomarkers is crucial for monitoring neonatal seizure dynamics. The present study aimed to characterize the temporal dynamics of neonatal seizures by analyzing intrinsic waveforms of epileptic electroencephalogram (EEG) signals. We proposed a complementary set of methods considering envelope power, focal sharpness changes, and nonlinear patterns of EEG signals of 79 neonates with seizures. Features derived from EEG signals were used as input to the machine learning classifier. All three characteristics were significantly elevated during seizure events, as agreed upon by all viewers (P < 0.0001). Envelope power was elevated in the entire seizure period, and the degree of nonlinearity rose at the termination of a seizure event. Epileptic sharpness effectively characterizes an entire seizure event, complementing the role of envelope power in identifying its onset. However, the degree of nonlinearity showed superior discriminability for the termination of a seizure event. The proposed computational methods for intrinsic sharp or nonlinear EEG patterns evolving during neonatal seizure could share some features with envelope power. Current findings may be helpful in developing strategies to improve neonatal seizure monitoring | ||
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| 700 | 1 | |a Shi, Wenbin |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Boyi |e verfasserin |4 aut | |
| 700 | 1 | |a An, Jianping |e verfasserin |4 aut | |
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