Prevalence of "Ghost Infarct Core" after Endovascular Thrombectomy
© 2024 by American Journal of Neuroradiology..
BACKGROUND AND PURPOSE: Baseline CTP sometimes overestimates the size of the infarct core ("ghost core" phenomenon). We investigated how often CTP overestimates infarct core compared with 24-hour imaging, and aimed to characterize the patient subgroup in whom a ghost core is most likely to occur.
MATERIALS AND METHODS: Data are from the randomized controlled ESCAPE-NA1 trial, in which patients with acute ischemic stroke undergoing endovascular treatment were randomized to intravenous nerinetide or placebo. Patients with available baseline CTP and 24-hour follow-up imaging were included in the analysis. Ghost infarct core was defined as CTP core volume minus 24-hour infarct volume > 10 mL). Clinical characteristics of patients with versus without ghost core were compared. Associations of ghost core and clinical characteristics were assessed by using multivariable logistic regression.
RESULTS: A total of 421 of 1105 patients (38.1%) were included in the analysis. Forty-seven (11.2%) had a ghost core > 10 mL, with a median ghost infarct volume of 13.4 mL (interquartile range 7.6-26.8). Young patient age, complete recanalization, short last known well to CT times, and possibly male sex were associated with ghost infarct core.
CONCLUSIONS: CTP ghost core occurred in ∼1 of 10 patients, indicating that CTP frequently overestimates the infarct core size at baseline, particularly in young patients with complete recanalization and short ischemia duration.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:45 |
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| Enthalten in: |
AJNR. American journal of neuroradiology - 45(2024), 3 vom: 07. März, Seite 291-295 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Ospel, Johanna M [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 11.03.2024 Date Revised 19.03.2024 published: Electronic Citation Status MEDLINE |
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| doi: |
10.3174/ajnr.A8113 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM367629828 |
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| 500 | |a Date Revised 19.03.2024 | ||
| 500 | |a published: Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2024 by American Journal of Neuroradiology. | ||
| 520 | |a BACKGROUND AND PURPOSE: Baseline CTP sometimes overestimates the size of the infarct core ("ghost core" phenomenon). We investigated how often CTP overestimates infarct core compared with 24-hour imaging, and aimed to characterize the patient subgroup in whom a ghost core is most likely to occur | ||
| 520 | |a MATERIALS AND METHODS: Data are from the randomized controlled ESCAPE-NA1 trial, in which patients with acute ischemic stroke undergoing endovascular treatment were randomized to intravenous nerinetide or placebo. Patients with available baseline CTP and 24-hour follow-up imaging were included in the analysis. Ghost infarct core was defined as CTP core volume minus 24-hour infarct volume > 10 mL). Clinical characteristics of patients with versus without ghost core were compared. Associations of ghost core and clinical characteristics were assessed by using multivariable logistic regression | ||
| 520 | |a RESULTS: A total of 421 of 1105 patients (38.1%) were included in the analysis. Forty-seven (11.2%) had a ghost core > 10 mL, with a median ghost infarct volume of 13.4 mL (interquartile range 7.6-26.8). Young patient age, complete recanalization, short last known well to CT times, and possibly male sex were associated with ghost infarct core | ||
| 520 | |a CONCLUSIONS: CTP ghost core occurred in ∼1 of 10 patients, indicating that CTP frequently overestimates the infarct core size at baseline, particularly in young patients with complete recanalization and short ischemia duration | ||
| 650 | 4 | |a Journal Article | |
| 700 | 1 | |a Rex, Nathaniel |e verfasserin |4 aut | |
| 700 | 1 | |a Rinkel, Leon |e verfasserin |4 aut | |
| 700 | 1 | |a Kashani, Nima |e verfasserin |4 aut | |
| 700 | 1 | |a Buck, Brian |e verfasserin |4 aut | |
| 700 | 1 | |a Rempel, Jeremy |e verfasserin |4 aut | |
| 700 | 1 | |a Sahlas, Demetrios |e verfasserin |4 aut | |
| 700 | 1 | |a Kelly, Michael E |e verfasserin |4 aut | |
| 700 | 1 | |a Budzik, Ron |e verfasserin |4 aut | |
| 700 | 1 | |a Tymianski, Michael |e verfasserin |4 aut | |
| 700 | 1 | |a Hill, Michael D |e verfasserin |4 aut | |
| 700 | 1 | |a Goyal, Mayank |e verfasserin |4 aut | |
| 700 | 0 | |a ESCAPE-NA1 Investigators |e verfasserin |4 aut | |
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