A lipid index for risk of hyperlipidemia caused by anti-retroviral drugs
Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved..
HIV-associated lipodystrophy has been reported in people taking anti-retroviral therapy (ART). Lipodystrophy can cause cardiovascular diseases, affecting the quality of life of HIV-infected individuals. In this study, we propose a pharmacological lipid index to estimate the risk of hyperlipidemia caused by anti-retroviral drugs. Lipid droplets were stained in cells treated with anti-retroviral drugs and cyclosporin A. Signal intensities of lipid droplets were plotted against the drug concentrations to obtain an isodose of 10 μM of cyclosporin A, which we call the Pharmacological Lipid Index (PLI). The PLI was then normalized by EC50. PLI/EC50 values were low in early proteinase inhibitors and the nucleoside reverse transcriptase inhibitor, d4T, indicating high risk of hyperlipidemia, which is consistent with previous findings of hyperlipidemia. In contrast, there are few reports of hyperlipidemia for drugs with high PLI/EC50 scores. Data suggests that PLI/EC50 is a useful index for estimating the risk of hyperlipidemia.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2024 |
|---|---|
| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:223 |
|---|---|
| Enthalten in: |
Antiviral research - 223(2024) vom: 15. März, Seite 105819 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Shimura, Mari [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
83HN0GTJ6D |
|---|
| Anmerkungen: |
Date Completed 04.03.2024 Date Revised 04.03.2024 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1016/j.antiviral.2024.105819 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM367627310 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM367627310 | ||
| 003 | DE-627 | ||
| 005 | 20240304232336.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240126s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.antiviral.2024.105819 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1316.xml |
| 035 | |a (DE-627)NLM367627310 | ||
| 035 | |a (NLM)38272319 | ||
| 035 | |a (PII)S0166-3542(24)00027-5 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Shimura, Mari |e verfasserin |4 aut | |
| 245 | 1 | 2 | |a A lipid index for risk of hyperlipidemia caused by anti-retroviral drugs |
| 264 | 1 | |c 2024 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 04.03.2024 | ||
| 500 | |a Date Revised 04.03.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved. | ||
| 520 | |a HIV-associated lipodystrophy has been reported in people taking anti-retroviral therapy (ART). Lipodystrophy can cause cardiovascular diseases, affecting the quality of life of HIV-infected individuals. In this study, we propose a pharmacological lipid index to estimate the risk of hyperlipidemia caused by anti-retroviral drugs. Lipid droplets were stained in cells treated with anti-retroviral drugs and cyclosporin A. Signal intensities of lipid droplets were plotted against the drug concentrations to obtain an isodose of 10 μM of cyclosporin A, which we call the Pharmacological Lipid Index (PLI). The PLI was then normalized by EC50. PLI/EC50 values were low in early proteinase inhibitors and the nucleoside reverse transcriptase inhibitor, d4T, indicating high risk of hyperlipidemia, which is consistent with previous findings of hyperlipidemia. In contrast, there are few reports of hyperlipidemia for drugs with high PLI/EC50 scores. Data suggests that PLI/EC50 is a useful index for estimating the risk of hyperlipidemia | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Anti-retroviral drugs | |
| 650 | 4 | |a EC50 | |
| 650 | 4 | |a HIV | |
| 650 | 4 | |a Hyperlipidemia | |
| 650 | 4 | |a Lipid droplets | |
| 650 | 4 | |a X-ray fluorescence microscopy | |
| 650 | 7 | |a Cyclosporine |2 NLM | |
| 650 | 7 | |a 83HN0GTJ6D |2 NLM | |
| 650 | 7 | |a Lipids |2 NLM | |
| 700 | 1 | |a Higashi-Kuwata, Nobuyo |e verfasserin |4 aut | |
| 700 | 1 | |a Fujiwara, Asuka |e verfasserin |4 aut | |
| 700 | 1 | |a Taniguchi, Mai |e verfasserin |4 aut | |
| 700 | 1 | |a Ichinose, Takayuki |e verfasserin |4 aut | |
| 700 | 1 | |a Hamano, Fumie |e verfasserin |4 aut | |
| 700 | 1 | |a Uematsu, Masaaki |e verfasserin |4 aut | |
| 700 | 1 | |a Inoue, Takato |e verfasserin |4 aut | |
| 700 | 1 | |a Matsuyama, Satoshi |e verfasserin |4 aut | |
| 700 | 1 | |a Suzuki, Takahiro |e verfasserin |4 aut | |
| 700 | 1 | |a Ghosh, Arun K |e verfasserin |4 aut | |
| 700 | 1 | |a Shindou, Hideo |e verfasserin |4 aut | |
| 700 | 1 | |a Shimuzu, Takao |e verfasserin |4 aut | |
| 700 | 1 | |a Mitsuya, Hiroaki |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Antiviral research |d 1983 |g 223(2024) vom: 15. März, Seite 105819 |w (DE-627)NLM012601756 |x 1872-9096 |7 nnns |
| 773 | 1 | 8 | |g volume:223 |g year:2024 |g day:15 |g month:03 |g pages:105819 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.antiviral.2024.105819 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 223 |j 2024 |b 15 |c 03 |h 105819 | ||