Long-term endocrine sequelae after hematopoietic stem cell transplantation in children and adolescents
Purpose: As the survival rate for pediatric cancers increases significantly with advances in treatment modalities, long-term endocrine complications have also risen. This study investigated the frequencies and risks of endocrine sequelae of childhood cancer survivors after hematopoietic stem cell transplantation (HSCT).
Methods: This study included 200 pediatric patients who underwent HSCT. Clinical and endocrinological findings were collected retrospectively. Median follow-up duration after HSCT was 14 years.
Results: Endocrine complications occurred in 135 patients (67.5%). Children who underwent HSCT at pubertal age (n = 100) were at higher risk of endocrine complications than prepubertal age (79% vs. 56%, P = 0.001). The most common complication was hypogonadism (40%), followed by dyslipidemia (22%). Short stature and diabetes mellitus were more prevalent in the prepubertal group, whereas hypogonadism and osteoporosis were more common in the pubertal group. Female, pubertal age at HSCT, and glucocorticoid use were predictors of increased risk for any complication. Radiation exposure increased the risk of short stature and hypothyroidism. Hypogonadism was significantly associated with female, pubertal age at HSCT, and high-dose radiation. Pubertal age at HSCT also increased the risks of osteoporosis and dyslipidemia.
Conclusion: This study demonstrated that long-term endocrine complications are common after HSCT in children and adolescents. Age at HSCT is a critical factor for endocrine complications after HSCT. These findings suggest that surveillance strategies for endocrine complications in childhood cancer survivors should be specified according to age at HSCT.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2024 |
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| Enthalten in: |
Annals of pediatric endocrinology & metabolism - (2024) vom: 24. Jan. |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Hwang, Soojin [VerfasserIn] |
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| Links: |
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| Themen: |
Children |
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| Anmerkungen: |
Date Revised 25.01.2024 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.6065/apem.2346046.023 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM367624117 |
|---|
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| 245 | 1 | 0 | |a Long-term endocrine sequelae after hematopoietic stem cell transplantation in children and adolescents |
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| 500 | |a Date Revised 25.01.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status Publisher | ||
| 520 | |a Purpose: As the survival rate for pediatric cancers increases significantly with advances in treatment modalities, long-term endocrine complications have also risen. This study investigated the frequencies and risks of endocrine sequelae of childhood cancer survivors after hematopoietic stem cell transplantation (HSCT) | ||
| 520 | |a Methods: This study included 200 pediatric patients who underwent HSCT. Clinical and endocrinological findings were collected retrospectively. Median follow-up duration after HSCT was 14 years | ||
| 520 | |a Results: Endocrine complications occurred in 135 patients (67.5%). Children who underwent HSCT at pubertal age (n = 100) were at higher risk of endocrine complications than prepubertal age (79% vs. 56%, P = 0.001). The most common complication was hypogonadism (40%), followed by dyslipidemia (22%). Short stature and diabetes mellitus were more prevalent in the prepubertal group, whereas hypogonadism and osteoporosis were more common in the pubertal group. Female, pubertal age at HSCT, and glucocorticoid use were predictors of increased risk for any complication. Radiation exposure increased the risk of short stature and hypothyroidism. Hypogonadism was significantly associated with female, pubertal age at HSCT, and high-dose radiation. Pubertal age at HSCT also increased the risks of osteoporosis and dyslipidemia | ||
| 520 | |a Conclusion: This study demonstrated that long-term endocrine complications are common after HSCT in children and adolescents. Age at HSCT is a critical factor for endocrine complications after HSCT. These findings suggest that surveillance strategies for endocrine complications in childhood cancer survivors should be specified according to age at HSCT | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Children | |
| 650 | 4 | |a Endocrine complication | |
| 650 | 4 | |a Hematopoietic stem cell transplantation | |
| 700 | 1 | |a Lee, Yena |e verfasserin |4 aut | |
| 700 | 1 | |a Yoon, Ji-Hee |e verfasserin |4 aut | |
| 700 | 1 | |a Kim, Ja Hye |e verfasserin |4 aut | |
| 700 | 1 | |a Kim, Hyery |e verfasserin |4 aut | |
| 700 | 1 | |a Koh, Kyung-Nam |e verfasserin |4 aut | |
| 700 | 1 | |a Im, Ho Joon |e verfasserin |4 aut | |
| 700 | 1 | |a Yoo, Han-Wook |e verfasserin |4 aut | |
| 700 | 1 | |a Choi, Jin-Ho |e verfasserin |4 aut | |
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