Insight into modulators of sphingosine-1-phosphate receptor and implications for cardiovascular therapeutics
Cardiovascular disease is the leading cause of death worldwide, and it's of great importance to understand its underlying mechanisms and find new treatments. Sphingosine 1-phosphate (S1P) is an active lipid that exerts its effects through S1P receptors on the cell surface or intracellular signal, and regulates many cellular processes such as cell growth, cell proliferation, cell migration, cell survival, and so on. S1PR modulators are a class of modulators that can interact with S1PR subtypes to activate receptors or block their activity, exerting either agonist or functional antagonist effects. Many studies have shown that S1P plays a protective role in the cardiovascular system and regulates cardiac physiological functions mainly through interaction with cell surface S1P receptors (S1PRs). Therefore, S1PR modulators may play a therapeutic role in cardiovascular diseases. Here, we review five S1PRs and their functions and the progress of S1PR modulators. In addition, we focus on the effects of S1PR modulators on atherosclerosis, myocardial infarction, myocardial ischaemia/reperfusion injury, diabetic cardiovascular diseases, and myocarditis, which may provide valuable insights into potential therapeutic strategies for cardiovascular disease.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2024 |
---|---|
Erschienen: |
2024 |
Enthalten in: |
Zur Gesamtaufnahme - volume:32 |
---|---|
Enthalten in: |
Journal of drug targeting - 32(2024), 3 vom: 15. Feb., Seite 300-310 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Xie, Yu-Xin [VerfasserIn] |
---|
Links: |
---|
Anmerkungen: |
Date Completed 16.02.2024 Date Revised 16.02.2024 published: Print-Electronic Citation Status MEDLINE |
---|
doi: |
10.1080/1061186X.2024.2309577 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM367602938 |
---|
LEADER | 01000caa a22002652 4500 | ||
---|---|---|---|
001 | NLM367602938 | ||
003 | DE-627 | ||
005 | 20240216232745.0 | ||
007 | cr uuu---uuuuu | ||
008 | 240125s2024 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1080/1061186X.2024.2309577 |2 doi | |
028 | 5 | 2 | |a pubmed24n1295.xml |
035 | |a (DE-627)NLM367602938 | ||
035 | |a (NLM)38269855 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Xie, Yu-Xin |e verfasserin |4 aut | |
245 | 1 | 0 | |a Insight into modulators of sphingosine-1-phosphate receptor and implications for cardiovascular therapeutics |
264 | 1 | |c 2024 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Completed 16.02.2024 | ||
500 | |a Date Revised 16.02.2024 | ||
500 | |a published: Print-Electronic | ||
500 | |a Citation Status MEDLINE | ||
520 | |a Cardiovascular disease is the leading cause of death worldwide, and it's of great importance to understand its underlying mechanisms and find new treatments. Sphingosine 1-phosphate (S1P) is an active lipid that exerts its effects through S1P receptors on the cell surface or intracellular signal, and regulates many cellular processes such as cell growth, cell proliferation, cell migration, cell survival, and so on. S1PR modulators are a class of modulators that can interact with S1PR subtypes to activate receptors or block their activity, exerting either agonist or functional antagonist effects. Many studies have shown that S1P plays a protective role in the cardiovascular system and regulates cardiac physiological functions mainly through interaction with cell surface S1P receptors (S1PRs). Therefore, S1PR modulators may play a therapeutic role in cardiovascular diseases. Here, we review five S1PRs and their functions and the progress of S1PR modulators. In addition, we focus on the effects of S1PR modulators on atherosclerosis, myocardial infarction, myocardial ischaemia/reperfusion injury, diabetic cardiovascular diseases, and myocarditis, which may provide valuable insights into potential therapeutic strategies for cardiovascular disease | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Review | |
650 | 4 | |a Sphingosine-1-phosphate receptors modulators | |
650 | 4 | |a atherosclerosis | |
650 | 4 | |a cardiovascular disease | |
650 | 4 | |a myocardial ischemia/reperfusion injury | |
650 | 4 | |a myocarditis | |
650 | 4 | |a sphingosine-1-phosphate receptors | |
650 | 7 | |a Sphingosine-1-Phosphate Receptors |2 NLM | |
650 | 7 | |a Receptors, Lysosphingolipid |2 NLM | |
650 | 7 | |a sphingosine 1-phosphate |2 NLM | |
650 | 7 | |a 26993-30-6 |2 NLM | |
650 | 7 | |a Lysophospholipids |2 NLM | |
650 | 7 | |a Sphingosine |2 NLM | |
650 | 7 | |a NGZ37HRE42 |2 NLM | |
700 | 1 | |a Yao, Hui |e verfasserin |4 aut | |
700 | 1 | |a Peng, Jin-Fu |e verfasserin |4 aut | |
700 | 1 | |a Ni, Dan |e verfasserin |4 aut | |
700 | 1 | |a Liu, Wan-Ting |e verfasserin |4 aut | |
700 | 1 | |a Li, Chao-Quan |e verfasserin |4 aut | |
700 | 1 | |a Yi, Guang-Hui |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Journal of drug targeting |d 1996 |g 32(2024), 3 vom: 15. Feb., Seite 300-310 |w (DE-627)NLM074733958 |x 1029-2330 |7 nnns |
773 | 1 | 8 | |g volume:32 |g year:2024 |g number:3 |g day:15 |g month:02 |g pages:300-310 |
856 | 4 | 0 | |u http://dx.doi.org/10.1080/1061186X.2024.2309577 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 32 |j 2024 |e 3 |b 15 |c 02 |h 300-310 |