Prognostic value of preoperative geriatric nutritional risk index in intrahepatic cholangiocarcinoma after hepatectomy : a single‑center retrospective cohort study
© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature..
AIM: Patients with malignant tumors are prone to develop nutritional disorders. The Geriatric Nutritional Risk Index (GNRI) is a new prognostic indicator for assessing the nutritional status. This study was performed to evaluate whether the preoperative GNRI can serve as a prognostic factor in patients with intrahepatic cholangiocarcinoma (ICC) undergoing curative surgery.
METHODS: This study included 123 consecutive patients with ICC who were treated with curative surgery. Kaplan-Meier analysis was performed to calculate the recurrence-free survival (RFS) and overall survival (OS), and Cox regression analysis was used to evaluate prognostic factors.
RESULTS: Of the 123 patients, 82 were male and 41 were female. The median age of the patients was 70 years, and the median follow-up period was 37.0 months (interquartile range, 16.2-71.7 months). The patients were classified by the median GNRI into a low GNRI group (GNRI < 105) and high GNRI group (GNRI ≥ 105). The patients in the low GNRI group had a significantly poorer prognosis in terms of RFS and OS than the patients in the high GNRI group (RFS, p = 0.0201; OS, p < 0.0001). Lymph node metastasis [hazard ratio (HR), 4.66; 95% confidence interval (CI), 2.46-8.85], postoperative complications (HR, 2.38; 95% CI, 1.32-4.31), and a low GNRI (HR, 2.53; 95% CI, 1.42-4.50) were independent poor prognostic factors for OS.
CONCLUSION: The GNRI may be a useful prognostic indicator in patients with ICC undergoing curative hepatectomy.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:409 |
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| Enthalten in: |
Langenbeck's archives of surgery - 409(2024), 1 vom: 25. Jan., Seite 47 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Ogawa, Daisuke [VerfasserIn] |
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| Links: |
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| Themen: |
Geriatric Nutritional Risk Index |
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| Anmerkungen: |
Date Completed 26.01.2024 Date Revised 26.01.2024 published: Electronic Citation Status MEDLINE |
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| doi: |
10.1007/s00423-023-03221-8 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM367581922 |
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| 100 | 1 | |a Ogawa, Daisuke |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Prognostic value of preoperative geriatric nutritional risk index in intrahepatic cholangiocarcinoma after hepatectomy |b a single‑center retrospective cohort study |
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| 500 | |a published: Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. | ||
| 520 | |a AIM: Patients with malignant tumors are prone to develop nutritional disorders. The Geriatric Nutritional Risk Index (GNRI) is a new prognostic indicator for assessing the nutritional status. This study was performed to evaluate whether the preoperative GNRI can serve as a prognostic factor in patients with intrahepatic cholangiocarcinoma (ICC) undergoing curative surgery | ||
| 520 | |a METHODS: This study included 123 consecutive patients with ICC who were treated with curative surgery. Kaplan-Meier analysis was performed to calculate the recurrence-free survival (RFS) and overall survival (OS), and Cox regression analysis was used to evaluate prognostic factors | ||
| 520 | |a RESULTS: Of the 123 patients, 82 were male and 41 were female. The median age of the patients was 70 years, and the median follow-up period was 37.0 months (interquartile range, 16.2-71.7 months). The patients were classified by the median GNRI into a low GNRI group (GNRI < 105) and high GNRI group (GNRI ≥ 105). The patients in the low GNRI group had a significantly poorer prognosis in terms of RFS and OS than the patients in the high GNRI group (RFS, p = 0.0201; OS, p < 0.0001). Lymph node metastasis [hazard ratio (HR), 4.66; 95% confidence interval (CI), 2.46-8.85], postoperative complications (HR, 2.38; 95% CI, 1.32-4.31), and a low GNRI (HR, 2.53; 95% CI, 1.42-4.50) were independent poor prognostic factors for OS | ||
| 520 | |a CONCLUSION: The GNRI may be a useful prognostic indicator in patients with ICC undergoing curative hepatectomy | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Geriatric Nutritional Risk Index | |
| 650 | 4 | |a Hepatectomy | |
| 650 | 4 | |a Intrahepatic cholangiocarcinoma | |
| 650 | 4 | |a Overall survival | |
| 650 | 4 | |a Recurrence free survival | |
| 700 | 1 | |a Miyata, Tatsunori |e verfasserin |4 aut | |
| 700 | 1 | |a Yumoto, Shinsei |e verfasserin |4 aut | |
| 700 | 1 | |a Shiraishi, Yuta |e verfasserin |4 aut | |
| 700 | 1 | |a Matsumoto, Takashi |e verfasserin |4 aut | |
| 700 | 1 | |a Takematsu, Toru |e verfasserin |4 aut | |
| 700 | 1 | |a Tsukamoto, Masayo |e verfasserin |4 aut | |
| 700 | 1 | |a Nakagawa, Shigeki |e verfasserin |4 aut | |
| 700 | 1 | |a Mima, Kosuke |e verfasserin |4 aut | |
| 700 | 1 | |a Nitta, Hidetoshi |e verfasserin |4 aut | |
| 700 | 1 | |a Hayashi, Hiromitsu |e verfasserin |4 aut | |
| 700 | 1 | |a Baba, Hideo |e verfasserin |4 aut | |
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