Paradoxical tuberculosis reaction
Copyright © 2024 Société Nationale Française de Médecine Interne (SNFMI). Published by Elsevier Masson SAS. All rights reserved..
Paradoxical tuberculosis reaction is defined as the aggravation of lesions present at diagnosis or the development of new lesions under anti-tuberculosis treatment, after exclusion of other alternate causes. It affects 5 to 30% of tuberculosis patients, with a variable prevalence depending on the site of infection and the clinical background. The diagnosis of paradoxical reaction is one of elimination, and requires having ruled out therapeutic failure, notably linked to poor compliance and/or to the presence of mycobacterial antibiotic resistance. The severity of paradoxical tuberculosis reaction lies in its neurological impairment. Despite its clinical importance, the mechanisms involved remain poorly understood and its management is not consensual. Corticosteroids are the cornerstone in the medical management. The role of anti-TNF agents, currently proposed in cases of corticodependence or corticoresistance, remains to be properly defined.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2024 |
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| Enthalten in: |
La Revue de medecine interne - (2024) vom: 23. Jan. |
| Sprache: |
Französisch |
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| Weiterer Titel: |
Réaction paradoxale tuberculeuse |
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| Beteiligte Personen: |
Azoulay, L-D [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Revised 24.01.2024 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.1016/j.revmed.2024.01.008 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM367577437 |
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| 520 | |a Paradoxical tuberculosis reaction is defined as the aggravation of lesions present at diagnosis or the development of new lesions under anti-tuberculosis treatment, after exclusion of other alternate causes. It affects 5 to 30% of tuberculosis patients, with a variable prevalence depending on the site of infection and the clinical background. The diagnosis of paradoxical reaction is one of elimination, and requires having ruled out therapeutic failure, notably linked to poor compliance and/or to the presence of mycobacterial antibiotic resistance. The severity of paradoxical tuberculosis reaction lies in its neurological impairment. Despite its clinical importance, the mechanisms involved remain poorly understood and its management is not consensual. Corticosteroids are the cornerstone in the medical management. The role of anti-TNF agents, currently proposed in cases of corticodependence or corticoresistance, remains to be properly defined | ||
| 650 | 4 | |a English Abstract | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a Anti-TNF | |
| 650 | 4 | |a Corticosteroid | |
| 650 | 4 | |a Corticoïdes | |
| 650 | 4 | |a Granulomatose | |
| 650 | 4 | |a Granulomatosis | |
| 650 | 4 | |a Immune reconstitution inflammatory syndrome | |
| 650 | 4 | |a Paradoxical reaction | |
| 650 | 4 | |a Réaction paradoxale | |
| 650 | 4 | |a Syndrome inflammatoire de reconstitution immune | |
| 650 | 4 | |a Tuberculose | |
| 650 | 4 | |a Tuberculosis | |
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| 700 | 1 | |a Gallien, S |e verfasserin |4 aut | |
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