Sex Differences in Epidemiological Distribution and Outcomes of Surgical Mitral Valve Disease
BACKGROUND: Mitral valve (MV) disease is the most common form of valvular heart disease. Findings that indicate women have a higher risk for unfavorable outcomes than men remain controversial. This study aimed to determine the sex-based differences in epidemiological distributions and outcomes of surgery for MV disease.Methods and Results: Overall, 18,572 patients (45.3% women) who underwent MV surgery between 2001 and 2018 were included. Outcomes included in-hospital death and all-cause mortality during follow up. Subgroup analysis was conducted across different etiologies, including infective endocarditis (IE), degenerative, ischemic, and rheumatic mitral pathology. The overall MV repair rate was lower in women than in men (20.5% vs. 30.6%). After matching, 6,362 pairs (woman : man=1 : 1) of patients were analyzed. Women had a slightly higher risk for in-hospital death than men (10.8% vs. 9.8%; odds ratio [OR]: 1.11, 95% confidence interval [CI]: 0.99-1.24; P=0.075). Women tended to have a higher incidence of de novo dialysis (9.8% vs. 8.6%; P=0.022) and longer intensive care unit stay (8 days vs. 7.1 days; P<0.001). Women with IE had poorer in-hospital outcomes than men; however, there were no sex differences in terms of all-cause mortality.
CONCLUSIONS: Sex-based differences of MV intervention still persist. Although long-term outcomes were comparable between sexes, women, especially those with IE, had worse perioperative outcomes than men.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2024 |
|---|---|
| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:88 |
|---|---|
| Enthalten in: |
Circulation journal : official journal of the Japanese Circulation Society - 88(2024), 4 vom: 25. März, Seite 579-588 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Chang, Feng-Cheng [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Journal Article |
|---|
| Anmerkungen: |
Date Completed 26.03.2024 Date Revised 26.03.2024 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1253/circj.CJ-23-0687 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM367574632 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM367574632 | ||
| 003 | DE-627 | ||
| 005 | 20240326235304.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240125s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1253/circj.CJ-23-0687 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1348.xml |
| 035 | |a (DE-627)NLM367574632 | ||
| 035 | |a (NLM)38267036 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Chang, Feng-Cheng |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Sex Differences in Epidemiological Distribution and Outcomes of Surgical Mitral Valve Disease |
| 264 | 1 | |c 2024 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 26.03.2024 | ||
| 500 | |a Date Revised 26.03.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a BACKGROUND: Mitral valve (MV) disease is the most common form of valvular heart disease. Findings that indicate women have a higher risk for unfavorable outcomes than men remain controversial. This study aimed to determine the sex-based differences in epidemiological distributions and outcomes of surgery for MV disease.Methods and Results: Overall, 18,572 patients (45.3% women) who underwent MV surgery between 2001 and 2018 were included. Outcomes included in-hospital death and all-cause mortality during follow up. Subgroup analysis was conducted across different etiologies, including infective endocarditis (IE), degenerative, ischemic, and rheumatic mitral pathology. The overall MV repair rate was lower in women than in men (20.5% vs. 30.6%). After matching, 6,362 pairs (woman : man=1 : 1) of patients were analyzed. Women had a slightly higher risk for in-hospital death than men (10.8% vs. 9.8%; odds ratio [OR]: 1.11, 95% confidence interval [CI]: 0.99-1.24; P=0.075). Women tended to have a higher incidence of de novo dialysis (9.8% vs. 8.6%; P=0.022) and longer intensive care unit stay (8 days vs. 7.1 days; P<0.001). Women with IE had poorer in-hospital outcomes than men; however, there were no sex differences in terms of all-cause mortality | ||
| 520 | |a CONCLUSIONS: Sex-based differences of MV intervention still persist. Although long-term outcomes were comparable between sexes, women, especially those with IE, had worse perioperative outcomes than men | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Mitral valve surgery | |
| 650 | 4 | |a Mortality | |
| 650 | 4 | |a Sex differences | |
| 650 | 4 | |a Women | |
| 700 | 1 | |a Chen, Chun-Yu |e verfasserin |4 aut | |
| 700 | 1 | |a Chan, Yi-Hsin |e verfasserin |4 aut | |
| 700 | 1 | |a Cheng, Yu-Ting |e verfasserin |4 aut | |
| 700 | 1 | |a Lin, Chia-Pin |e verfasserin |4 aut | |
| 700 | 1 | |a Wu, Victor Chien-Chia |e verfasserin |4 aut | |
| 700 | 1 | |a Hung, Kuo-Chun |e verfasserin |4 aut | |
| 700 | 1 | |a Chu, Pao-Hsien |e verfasserin |4 aut | |
| 700 | 1 | |a Chou, An-Hsun |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Shao-Wei |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Circulation journal : official journal of the Japanese Circulation Society |d 2002 |g 88(2024), 4 vom: 25. März, Seite 579-588 |w (DE-627)NLM118044850 |x 1347-4820 |7 nnns |
| 773 | 1 | 8 | |g volume:88 |g year:2024 |g number:4 |g day:25 |g month:03 |g pages:579-588 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1253/circj.CJ-23-0687 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 88 |j 2024 |e 4 |b 25 |c 03 |h 579-588 | ||