Cone-beam computed tomography-guided online adaptive radiotherapy for pharyngeal cancer with whole neck irradiation : dose-volume histogram analysis between adapted and scheduled plans
© The Author(s) 2024. Published by Oxford University Press on behalf of The Japanese Radiation Research Society and Japanese Society for Radiation Oncology..
The present study aimed to evaluate whether an adapted plan with Ethos™ could be used for pharyngeal cancer. Ten patients with pharyngeal cancer who underwent chemoradiotherapy with available daily cone-beam computed tomography (CBCT) data were included. Simulated treatments were generated on the Ethos™ treatment emulator using CBCTs every four to five fractions for two plans: adapted and scheduled. The simulated treatments were divided into three groups: early (first-second week), middle (third-fourth week), and late (fifth-seventh week) periods. Dose-volume histogram parameters were compared for each period between the adapted and scheduled plans in terms of the planning target volume (PTV) (D98%, D95%, D50% and D2%), spinal cord (Dmax and D1cc), brainstem (Dmax) and ipsilateral and contralateral parotid glands (Dmedian and Dmean). The PTV D98%, D95% and D2% of the adapted plan were significantly higher than those of the scheduled plans in all periods, except for D98% in the late period. The adapted plan significantly reduced the spinal cord Dmax and D1cc compared with the scheduled plan in all periods. Ipsilateral and contralateral parotid glands Dmean of the adapted plan were lower than those of scheduled plan in the late period. In conclusion, the present study revealed that the adapted plans could maintain PTV coverage while reducing the doses to organs at risk in each period compared with scheduled plans.
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2024 |
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Erschienen: |
2024 |
Enthalten in: |
Zur Gesamtaufnahme - volume:65 |
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Enthalten in: |
Journal of radiation research - 65(2024), 2 vom: 22. März, Seite 223-230 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Uehara, Takuya [VerfasserIn] |
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Links: |
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Themen: |
Adaptive radiotherapy |
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Anmerkungen: |
Date Completed 25.03.2024 Date Revised 25.03.2024 published: Print Citation Status MEDLINE |
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doi: |
10.1093/jrr/rrad103 |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM367552582 |
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520 | |a © The Author(s) 2024. Published by Oxford University Press on behalf of The Japanese Radiation Research Society and Japanese Society for Radiation Oncology. | ||
520 | |a The present study aimed to evaluate whether an adapted plan with Ethos™ could be used for pharyngeal cancer. Ten patients with pharyngeal cancer who underwent chemoradiotherapy with available daily cone-beam computed tomography (CBCT) data were included. Simulated treatments were generated on the Ethos™ treatment emulator using CBCTs every four to five fractions for two plans: adapted and scheduled. The simulated treatments were divided into three groups: early (first-second week), middle (third-fourth week), and late (fifth-seventh week) periods. Dose-volume histogram parameters were compared for each period between the adapted and scheduled plans in terms of the planning target volume (PTV) (D98%, D95%, D50% and D2%), spinal cord (Dmax and D1cc), brainstem (Dmax) and ipsilateral and contralateral parotid glands (Dmedian and Dmean). The PTV D98%, D95% and D2% of the adapted plan were significantly higher than those of the scheduled plans in all periods, except for D98% in the late period. The adapted plan significantly reduced the spinal cord Dmax and D1cc compared with the scheduled plan in all periods. Ipsilateral and contralateral parotid glands Dmean of the adapted plan were lower than those of scheduled plan in the late period. In conclusion, the present study revealed that the adapted plans could maintain PTV coverage while reducing the doses to organs at risk in each period compared with scheduled plans | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a adaptive radiotherapy | |
650 | 4 | |a cone-beam computed tomography-guided online adaptive radiotherapy | |
650 | 4 | |a intensity modulated radiation therapy | |
650 | 4 | |a pharyngeal cancer | |
650 | 4 | |a radiotherapy | |
650 | 4 | |a whole neck irradiation | |
700 | 1 | |a Nishimura, Yasumasa |e verfasserin |4 aut | |
700 | 1 | |a Ishikawa, Kazuki |e verfasserin |4 aut | |
700 | 1 | |a Inada, Masahiro |e verfasserin |4 aut | |
700 | 1 | |a Matsumoto, Kenji |e verfasserin |4 aut | |
700 | 1 | |a Doi, Hiroshi |e verfasserin |4 aut | |
700 | 1 | |a Monzen, Hajime |e verfasserin |4 aut | |
700 | 1 | |a Matsuo, Yukinori |e verfasserin |4 aut | |
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