Platelet-Derived Growth Factor Nanocapsules with Tunable Controlled Release for Chronic Wound Healing
© 2024 Wiley-VCH GmbH..
Chronic wounds have emerged as an increasingly critical clinical challenge over the past few decades, due to their increasing incidence and socioeconomic burdens. Platelet-derived growth factor (PDGF) plays a pivotal role in regulating processes such as fibroblast migration, proliferation, and vascular formation during the wound healing process. The delivery of PDGF offers great potential for expediting the healing of chronic wounds. However, the clinical effectiveness of PDGF in chronic wound healing is significantly hampered by its inability to maintain a stable concentration at the wound site over an extended period. In this study, a controlled PDGF delivery system based on nanocapsules is proposed. In this system, PDGF is encapsulated within a degradable polymer shell. The release rate of PDGF from these nanocapsules can be precisely adjusted by controlling the ratios of two crosslinkers with different degradation rates within the shells. As demonstrated in a diabetic wound model, improved therapeutic outcomes with PDGF nanocapsules (nPDGF) treatment are observed. This research introduces a novel PDGF delivery platform that holds promise for enhancing the effectiveness of chronic wound healing.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2024 |
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| Enthalten in: |
Small (Weinheim an der Bergstrasse, Germany) - (2024) vom: 23. Jan., Seite e2310743 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Tang, Lin [VerfasserIn] |
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| Links: |
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| Themen: |
Chronic wound healing |
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| Anmerkungen: |
Date Revised 24.01.2024 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.1002/smll.202310743 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM367542293 |
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| 520 | |a Chronic wounds have emerged as an increasingly critical clinical challenge over the past few decades, due to their increasing incidence and socioeconomic burdens. Platelet-derived growth factor (PDGF) plays a pivotal role in regulating processes such as fibroblast migration, proliferation, and vascular formation during the wound healing process. The delivery of PDGF offers great potential for expediting the healing of chronic wounds. However, the clinical effectiveness of PDGF in chronic wound healing is significantly hampered by its inability to maintain a stable concentration at the wound site over an extended period. In this study, a controlled PDGF delivery system based on nanocapsules is proposed. In this system, PDGF is encapsulated within a degradable polymer shell. The release rate of PDGF from these nanocapsules can be precisely adjusted by controlling the ratios of two crosslinkers with different degradation rates within the shells. As demonstrated in a diabetic wound model, improved therapeutic outcomes with PDGF nanocapsules (nPDGF) treatment are observed. This research introduces a novel PDGF delivery platform that holds promise for enhancing the effectiveness of chronic wound healing | ||
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| 650 | 4 | |a nanocapsule | |
| 650 | 4 | |a platelet-derived growth factor | |
| 650 | 4 | |a protein delivery | |
| 700 | 1 | |a Cai, Susu |e verfasserin |4 aut | |
| 700 | 1 | |a Lu, Xing |e verfasserin |4 aut | |
| 700 | 1 | |a Wu, Dingqi |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Yahan |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Xiaoming |e verfasserin |4 aut | |
| 700 | 1 | |a Qin, Xiaoyan |e verfasserin |4 aut | |
| 700 | 1 | |a Guo, Jimin |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Xiaopeng |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Chaoyong |e verfasserin |4 aut | |
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