Male patients with inflammatory joint diseases are less likely than controls to be childless : results from a Norwegian population-based cohort study of 10 865 patients
© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ..
OBJECTIVES: To investigate the number of children per man and the proportion of childless men as a proxy of fertility in a national cohort of men with inflammatory joint diseases (IJDs), compared with matched controls from the general population.
METHODS: This is a nationwide, population-based retrospective cohort study. Male patients with IJDs (n = 10 865) in the Norwegian Arthritis Registry were individually matched 1:5 on birth year and county of residence with men without IJDs obtained from the National Population Register (n = 54 325). Birth data were obtained from the Medical Birth Registry of Norway. We compared the mean number of children per man and the proportion of childless men and analysed the impact of age and year of diagnosis.
RESULTS: The mean number of children per man in the patient group was 1.80 versus 1.69 in the comparison group (p <0.001), and 21% of the patients in the patient group were childless versus 27% in the comparison group (p <0.001). The finding of less childlessness and higher number of children per man remained consistent across age at diagnosis, except for those diagnosed at age 0-19 years. The difference in childlessness was most pronounced for men diagnosed after year 2000, especially when diagnosed at 30-39 years of age (22% vs 32%, p<0.001).
CONCLUSION: In this large cohort study we found that patients with IJD have a higher number of children and are less likely to be childless compared with controls. Factors associated with developing or having an IJD might influence fertility and this requires further investigation.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:83 |
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| Enthalten in: |
Annals of the rheumatic diseases - 83(2024), 4 vom: 12. März, Seite 457-463 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Sigmo, Gudrun David [VerfasserIn] |
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| Links: |
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| Themen: |
Arthritis |
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| Anmerkungen: |
Date Completed 14.03.2024 Date Revised 24.03.2024 published: Electronic Citation Status MEDLINE |
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| doi: |
10.1136/ard-2023-224998 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM367531135 |
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| 100 | 1 | |a Sigmo, Gudrun David |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Male patients with inflammatory joint diseases are less likely than controls to be childless |b results from a Norwegian population-based cohort study of 10 865 patients |
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| 500 | |a Date Revised 24.03.2024 | ||
| 500 | |a published: Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. | ||
| 520 | |a OBJECTIVES: To investigate the number of children per man and the proportion of childless men as a proxy of fertility in a national cohort of men with inflammatory joint diseases (IJDs), compared with matched controls from the general population | ||
| 520 | |a METHODS: This is a nationwide, population-based retrospective cohort study. Male patients with IJDs (n = 10 865) in the Norwegian Arthritis Registry were individually matched 1:5 on birth year and county of residence with men without IJDs obtained from the National Population Register (n = 54 325). Birth data were obtained from the Medical Birth Registry of Norway. We compared the mean number of children per man and the proportion of childless men and analysed the impact of age and year of diagnosis | ||
| 520 | |a RESULTS: The mean number of children per man in the patient group was 1.80 versus 1.69 in the comparison group (p <0.001), and 21% of the patients in the patient group were childless versus 27% in the comparison group (p <0.001). The finding of less childlessness and higher number of children per man remained consistent across age at diagnosis, except for those diagnosed at age 0-19 years. The difference in childlessness was most pronounced for men diagnosed after year 2000, especially when diagnosed at 30-39 years of age (22% vs 32%, p<0.001) | ||
| 520 | |a CONCLUSION: In this large cohort study we found that patients with IJD have a higher number of children and are less likely to be childless compared with controls. Factors associated with developing or having an IJD might influence fertility and this requires further investigation | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Arthritis | |
| 650 | 4 | |a Arthritis, Psoriatic | |
| 650 | 4 | |a Arthritis, Rheumatoid | |
| 650 | 4 | |a Epidemiology | |
| 650 | 4 | |a Spondylitis, Ankylosing | |
| 700 | 1 | |a Hauge, Solveig |e verfasserin |4 aut | |
| 700 | 1 | |a Hufthammer, Karl Ove |e verfasserin |4 aut | |
| 700 | 1 | |a Wallenius, Marianne |e verfasserin |4 aut | |
| 700 | 1 | |a Salvesen, Kjell Åsmund |e verfasserin |4 aut | |
| 700 | 1 | |a Daltveit, Anne Kjersti Nesje |e verfasserin |4 aut | |
| 700 | 1 | |a Bakland, Gunnstein |e verfasserin |4 aut | |
| 700 | 1 | |a Fevang, Bjorg-Tilde Svanes |e verfasserin |4 aut | |
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