In-vitro and In-silico Assessment of Anti-inflammation Properties of Saponarin Extracted from Hordeum Vulgare
Copyright© Bentham Science Publishers; For any queries, please email at epubbenthamscience.net..
BACKGROUND: Hordeum vulgare, commonly known as Barley grass, is a historically significant cultivated plant with profound implications for societies, agricultural sciences, and human nutrition. It has been valued for both sustenance and its potential medicinal properties.
OBJECTIVE: This study aims to comprehensively investigate the medicinal properties of Hordeum vulgare, focusing on its potential therapeutic benefits and anti-inflammatory properties. Additionally, we seek to quantify and compare the phytochemical content of two distinct extracts: Barley Grass Hexane Extract (BGHE) and Barley grass aqueous extract (BGAQ).
METHODS: We quantified the phytochemical contents of BGHE and BGAQ and evaluated their antiinflammatory effects using UV spectroscopy at 560 nm, coupled with the RBC membrane stabilization technique. Subsequently, we conducted in-silico studies to assess the in vitro anti-inflammatory potential of Barley grass leaf extracts.
RESULTS: Both BGHE and BGAQ demonstrated significant inhibitory effects on inflammation compared to the control group. However, BGHE exhibited superior anti-inflammatory efficacy when compared to BGAQ, suggesting its role as a potential anti-inflammatory agent. In-silico studies further supported the anti-inflammatory potential of Barley grass leaf extracts.
CONCLUSION: Hordeum vulgare, or Barley grass, offers a wealth of health benefits, including antiinflammatory, anti-diabetic, anti-cancer, antioxidant, anti-acne, and anti-depressant properties. These properties contribute to improved immunity, reduced cardiovascular disorders, and alleviation of fatigue. The distinct extracts, BGHE and BGAQ, both exhibit promising anti-inflammatory capabilities, but BGHE shows better anti-inflammatory activity. This research sheds light on the therapeutic potential of Barley grass, making it a valuable candidate for further exploration in the field of natural medicine.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2024 |
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| Enthalten in: |
Anti-inflammatory & anti-allergy agents in medicinal chemistry - (2024) vom: 22. Jan. |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Boyina, Revathi [VerfasserIn] |
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| Links: |
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| Themen: |
Anti-inflammatory activity |
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| Anmerkungen: |
Date Revised 23.01.2024 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.2174/0118715230284334240101100450 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM367492644 |
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| 520 | |a Copyright© Bentham Science Publishers; For any queries, please email at epubbenthamscience.net. | ||
| 520 | |a BACKGROUND: Hordeum vulgare, commonly known as Barley grass, is a historically significant cultivated plant with profound implications for societies, agricultural sciences, and human nutrition. It has been valued for both sustenance and its potential medicinal properties | ||
| 520 | |a OBJECTIVE: This study aims to comprehensively investigate the medicinal properties of Hordeum vulgare, focusing on its potential therapeutic benefits and anti-inflammatory properties. Additionally, we seek to quantify and compare the phytochemical content of two distinct extracts: Barley Grass Hexane Extract (BGHE) and Barley grass aqueous extract (BGAQ) | ||
| 520 | |a METHODS: We quantified the phytochemical contents of BGHE and BGAQ and evaluated their antiinflammatory effects using UV spectroscopy at 560 nm, coupled with the RBC membrane stabilization technique. Subsequently, we conducted in-silico studies to assess the in vitro anti-inflammatory potential of Barley grass leaf extracts | ||
| 520 | |a RESULTS: Both BGHE and BGAQ demonstrated significant inhibitory effects on inflammation compared to the control group. However, BGHE exhibited superior anti-inflammatory efficacy when compared to BGAQ, suggesting its role as a potential anti-inflammatory agent. In-silico studies further supported the anti-inflammatory potential of Barley grass leaf extracts | ||
| 520 | |a CONCLUSION: Hordeum vulgare, or Barley grass, offers a wealth of health benefits, including antiinflammatory, anti-diabetic, anti-cancer, antioxidant, anti-acne, and anti-depressant properties. These properties contribute to improved immunity, reduced cardiovascular disorders, and alleviation of fatigue. The distinct extracts, BGHE and BGAQ, both exhibit promising anti-inflammatory capabilities, but BGHE shows better anti-inflammatory activity. This research sheds light on the therapeutic potential of Barley grass, making it a valuable candidate for further exploration in the field of natural medicine | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a BGHE and BGAQ | |
| 650 | 4 | |a Barley grass | |
| 650 | 4 | |a RBC membrane stabilization | |
| 650 | 4 | |a UV-spectroscopy | |
| 650 | 4 | |a anti-inflammatory activity | |
| 650 | 4 | |a natural medicine | |
| 700 | 1 | |a Kosanam, Sreya |e verfasserin |4 aut | |
| 700 | 1 | |a Sasidhar, B |e verfasserin |4 aut | |
| 700 | 1 | |a Babu, G Raveendra |e verfasserin |4 aut | |
| 700 | 1 | |a Dhachinamoorthi, D |e verfasserin |4 aut | |
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