The In Vitro Assessment of Antibacterial and Antioxidant Efficacy in Rosa damascena and Hypericum perforatum Extracts against Pathogenic Strains in the Interplay of Dental Caries, Oral Health, and Food Microbiota
The rising demand for novel antibiotic agents prompts an investigation into natural resources, notably plant-derived compounds. In this study, various extracts (aqueous, ethanolic, aqueous-ethanolic, and enzymatic) of Rosa damascena and Hypericum perforatum were systematically evaluated against bacterial strains isolated from dental lesions (n = 6) and food sources (raw milk and broiler carcass, n = 2). Minimal inhibitory concentration (MIC), minimal bactericidal concentration (MBC), antibiofilm activity, and time-kill kinetics were assessed across a range of extract concentrations, revealing a dose-responsive effect. Notably, some extracts exhibited superior antibacterial efficacy compared to standard clinical antibiotics, and the time-kill kinetics demonstrated a rapid elimination of bacterial loads within 24 h. The susceptibility pattern proved strain-specific, contingent upon the extract type, yet all tested pathogens exhibited sensitivity. The identified extracts, rich in phenolic and polyphenolic compounds, as well as other antioxidant properties, contributed to their remarkable antibiotic effects. This comprehensive investigation not only highlights the potential of Rosa damascena and Hypericum perforatum extracts as potent antibacterial agents against diverse bacterial strains including caries pathogens, but also underscores their rapid action and dose-dependent efficacy. The findings suggest a promising avenue for harnessing plant-derived compounds in the development of novel antimicrobial strategies against dental caries and other oral inflammations, bridging the gap between natural resources and antibiotic discovery.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:12 |
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| Enthalten in: |
Microorganisms - 12(2023), 1 vom: 28. Dez. |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Antoniadou, Maria [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Revised 29.01.2024 published: Electronic Citation Status PubMed-not-MEDLINE |
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| doi: |
10.3390/microorganisms12010060 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM36748370X |
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| 245 | 1 | 4 | |a The In Vitro Assessment of Antibacterial and Antioxidant Efficacy in Rosa damascena and Hypericum perforatum Extracts against Pathogenic Strains in the Interplay of Dental Caries, Oral Health, and Food Microbiota |
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| 520 | |a The rising demand for novel antibiotic agents prompts an investigation into natural resources, notably plant-derived compounds. In this study, various extracts (aqueous, ethanolic, aqueous-ethanolic, and enzymatic) of Rosa damascena and Hypericum perforatum were systematically evaluated against bacterial strains isolated from dental lesions (n = 6) and food sources (raw milk and broiler carcass, n = 2). Minimal inhibitory concentration (MIC), minimal bactericidal concentration (MBC), antibiofilm activity, and time-kill kinetics were assessed across a range of extract concentrations, revealing a dose-responsive effect. Notably, some extracts exhibited superior antibacterial efficacy compared to standard clinical antibiotics, and the time-kill kinetics demonstrated a rapid elimination of bacterial loads within 24 h. The susceptibility pattern proved strain-specific, contingent upon the extract type, yet all tested pathogens exhibited sensitivity. The identified extracts, rich in phenolic and polyphenolic compounds, as well as other antioxidant properties, contributed to their remarkable antibiotic effects. This comprehensive investigation not only highlights the potential of Rosa damascena and Hypericum perforatum extracts as potent antibacterial agents against diverse bacterial strains including caries pathogens, but also underscores their rapid action and dose-dependent efficacy. The findings suggest a promising avenue for harnessing plant-derived compounds in the development of novel antimicrobial strategies against dental caries and other oral inflammations, bridging the gap between natural resources and antibiotic discovery | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Lactobacillus acidophilus | |
| 650 | 4 | |a Streptococcus mutans | |
| 650 | 4 | |a antibacterial efficacy | |
| 650 | 4 | |a antibiofilm activity | |
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| 650 | 4 | |a dental caries | |
| 650 | 4 | |a food extracts | |
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| 650 | 4 | |a minimal inhibitory concentration | |
| 650 | 4 | |a natural products chemistry | |
| 650 | 4 | |a oral health | |
| 650 | 4 | |a periodontitis | |
| 650 | 4 | |a phenolic compounds | |
| 650 | 4 | |a plants extracts | |
| 650 | 4 | |a time-kill kinetics | |
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| 700 | 1 | |a Ersanli, Caglar |e verfasserin |4 aut | |
| 700 | 1 | |a Alexopoulos, Athanasios |e verfasserin |4 aut | |
| 700 | 1 | |a Tzora, Athina |e verfasserin |4 aut | |
| 700 | 1 | |a Varzakas, Theodoros |e verfasserin |4 aut | |
| 700 | 1 | |a Voidarou, Chrysoula Chrysa |e verfasserin |4 aut | |
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