Rate and predictors of insufficient sweat volume in very young infants after pilocarpine gel iontophoresis : prospective, population-based study
© Author(s) (or their employer(s)) 2024. No commercial re-use. See rights and permissions. Published by BMJ..
OBJECTIVE: To verify the rate and predictors of 'quantity not sufficient' (QNS) among Brazilian infants younger than 3 months with positive newborn screening (NBS) for cystic fibrosis (CF).
DESIGN: Prospective, population-based study.
SETTING: Public Statewide Newborn Screening Programme where the incidence rate of CF is ≈1:11 000.
PATIENTS: Subjects with positive two-tiered immunoreactive trypsinogen.
INTERVENTIONS: Sweat induction and collection were performed in the same facility; one sweat sample was obtained per individual.
MAIN OUTCOME MEASURES: The QNS rate and its predictors; analysis corresponded to the day of sweat collection.
RESULTS: Among the 975 participants, QNS rates for 10 and 15 µL were 3.6% (95% CI 2.5% to 4.9%) and 8.3% (95% CI 6.6% to 10.2%). Infants weighing >3056 and >3845 g and with gestational age higher than 37 weeks had a greater likelihood (5.5 and 6.7, and 2.7 and 5.8 times more, respectively) of avoiding QNS than their peers.
CONCLUSION: QNS rates fulfilled the requirements, but predictors differed from those recommended by the Cystic Fibrosis Foundations guidelines.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:109 |
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| Enthalten in: |
Archives of disease in childhood - 109(2024), 4 vom: 19. März, Seite 304-307 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Camargos, Paulo [VerfasserIn] |
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| Links: |
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| Themen: |
01MI4Q9DI3 |
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| Anmerkungen: |
Date Completed 21.03.2024 Date Revised 21.03.2024 published: Electronic Citation Status MEDLINE |
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| doi: |
10.1136/archdischild-2023-326487 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM367439131 |
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| 245 | 1 | 0 | |a Rate and predictors of insufficient sweat volume in very young infants after pilocarpine gel iontophoresis |b prospective, population-based study |
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| 500 | |a Date Completed 21.03.2024 | ||
| 500 | |a Date Revised 21.03.2024 | ||
| 500 | |a published: Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © Author(s) (or their employer(s)) 2024. No commercial re-use. See rights and permissions. Published by BMJ. | ||
| 520 | |a OBJECTIVE: To verify the rate and predictors of 'quantity not sufficient' (QNS) among Brazilian infants younger than 3 months with positive newborn screening (NBS) for cystic fibrosis (CF) | ||
| 520 | |a DESIGN: Prospective, population-based study | ||
| 520 | |a SETTING: Public Statewide Newborn Screening Programme where the incidence rate of CF is ≈1:11 000 | ||
| 520 | |a PATIENTS: Subjects with positive two-tiered immunoreactive trypsinogen | ||
| 520 | |a INTERVENTIONS: Sweat induction and collection were performed in the same facility; one sweat sample was obtained per individual | ||
| 520 | |a MAIN OUTCOME MEASURES: The QNS rate and its predictors; analysis corresponded to the day of sweat collection | ||
| 520 | |a RESULTS: Among the 975 participants, QNS rates for 10 and 15 µL were 3.6% (95% CI 2.5% to 4.9%) and 8.3% (95% CI 6.6% to 10.2%). Infants weighing >3056 and >3845 g and with gestational age higher than 37 weeks had a greater likelihood (5.5 and 6.7, and 2.7 and 5.8 times more, respectively) of avoiding QNS than their peers | ||
| 520 | |a CONCLUSION: QNS rates fulfilled the requirements, but predictors differed from those recommended by the Cystic Fibrosis Foundations guidelines | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Cystic Fibrosis | |
| 650 | 4 | |a Global Health | |
| 650 | 7 | |a Pilocarpine |2 NLM | |
| 650 | 7 | |a 01MI4Q9DI3 |2 NLM | |
| 650 | 7 | |a Trypsinogen |2 NLM | |
| 650 | 7 | |a 9002-08-8 |2 NLM | |
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| 700 | 1 | |a Bedran, Renata Marcos |e verfasserin |4 aut | |
| 700 | 1 | |a Alvim, Cristina Gonçalves |e verfasserin |4 aut | |
| 700 | 1 | |a Sader, Olívia Gonçalves |e verfasserin |4 aut | |
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