Risk-Adapted Starting Age of Personalized Lung Cancer Screening : A Population-Based, Prospective Cohort Study in China
Copyright © 2024 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved..
BACKGROUND: The current one-size-fits-all screening strategy for lung cancer is not suitable for personalized screening.
RESEARCH QUESTION: What is the risk-adapted starting age of lung cancer screening with comprehensive consideration of risk factors?.
STUDY DESIGN AND METHODS: The National Lung Cancer Screening program, a multicenter, population-based, prospective cohort study, was analyzed. Information on risk factor exposure was collected during the baseline risk assessment. A Cox proportional hazards model was used to estimate the association between risk factors and lung cancer incidence. Age-specific 10-year cumulative risk was calculated to determine the age at which individuals with various risk factors reached the equivalent risk level as individuals 50 years of age with active tobacco use and a ≥ 20 pack-year smoking history.
RESULTS: Of the 1,031,911 participants enrolled in this study, 3,908 demonstrated lung cancer after a median follow-up of 3.8 years. We identified seven risk factors for lung cancer, including pack-years of smoking, secondhand smoke exposure, family history of lung cancer in first-degree relatives, history of respiratory diseases, occupational hazardous exposure, BMI, and diabetes. The 10-year cumulative risk of lung cancer for people 50 years of age with active tobacco use and a ≥ 20 pack-year smoking history was 1.37%, which was treated as the risk threshold for screening. Individuals who never smoked and those with active tobacco use and a < 30-pack-years history of smoking reached the equivalent risk level 1 to 14 years later compared with the starting age of 50 years. Men with active tobacco use, a ≥ 30-pack-years history of smoking, and concurrent respiratory diseases or diabetes should be screened 1 year earlier at age of 49 years.
INTERPRETATION: The personalized risk-adapted starting ages for lung cancer screening, based on the principle of equal management of equal risk, can served as an optimized screening strategy to identify high-risk individuals.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2024 |
|---|---|
| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2024 |
|---|---|
| Enthalten in: |
Chest - (2024) vom: 20. Jan. |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Wang, Chenran [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Journal Article |
|---|
| Anmerkungen: |
Date Revised 09.02.2024 published: Print-Electronic Citation Status Publisher |
|---|
| doi: |
10.1016/j.chest.2024.01.031 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM36743797X |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM36743797X | ||
| 003 | DE-627 | ||
| 005 | 20240210233147.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240123s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.chest.2024.01.031 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1287.xml |
| 035 | |a (DE-627)NLM36743797X | ||
| 035 | |a (NLM)38253312 | ||
| 035 | |a (PII)S0012-3692(24)00042-4 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Wang, Chenran |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Risk-Adapted Starting Age of Personalized Lung Cancer Screening |b A Population-Based, Prospective Cohort Study in China |
| 264 | 1 | |c 2024 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Revised 09.02.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status Publisher | ||
| 520 | |a Copyright © 2024 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved. | ||
| 520 | |a BACKGROUND: The current one-size-fits-all screening strategy for lung cancer is not suitable for personalized screening | ||
| 520 | |a RESEARCH QUESTION: What is the risk-adapted starting age of lung cancer screening with comprehensive consideration of risk factors? | ||
| 520 | |a STUDY DESIGN AND METHODS: The National Lung Cancer Screening program, a multicenter, population-based, prospective cohort study, was analyzed. Information on risk factor exposure was collected during the baseline risk assessment. A Cox proportional hazards model was used to estimate the association between risk factors and lung cancer incidence. Age-specific 10-year cumulative risk was calculated to determine the age at which individuals with various risk factors reached the equivalent risk level as individuals 50 years of age with active tobacco use and a ≥ 20 pack-year smoking history | ||
| 520 | |a RESULTS: Of the 1,031,911 participants enrolled in this study, 3,908 demonstrated lung cancer after a median follow-up of 3.8 years. We identified seven risk factors for lung cancer, including pack-years of smoking, secondhand smoke exposure, family history of lung cancer in first-degree relatives, history of respiratory diseases, occupational hazardous exposure, BMI, and diabetes. The 10-year cumulative risk of lung cancer for people 50 years of age with active tobacco use and a ≥ 20 pack-year smoking history was 1.37%, which was treated as the risk threshold for screening. Individuals who never smoked and those with active tobacco use and a < 30-pack-years history of smoking reached the equivalent risk level 1 to 14 years later compared with the starting age of 50 years. Men with active tobacco use, a ≥ 30-pack-years history of smoking, and concurrent respiratory diseases or diabetes should be screened 1 year earlier at age of 49 years | ||
| 520 | |a INTERPRETATION: The personalized risk-adapted starting ages for lung cancer screening, based on the principle of equal management of equal risk, can served as an optimized screening strategy to identify high-risk individuals | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a lung cancer | |
| 650 | 4 | |a personalized screening | |
| 650 | 4 | |a risk factors | |
| 650 | 4 | |a risk-adapted screening | |
| 650 | 4 | |a starting age of screening | |
| 700 | 1 | |a Dong, Xuesi |e verfasserin |4 aut | |
| 700 | 1 | |a Tan, Fengwei |e verfasserin |4 aut | |
| 700 | 1 | |a Wu, Zheng |e verfasserin |4 aut | |
| 700 | 1 | |a Huang, Yufei |e verfasserin |4 aut | |
| 700 | 1 | |a Zheng, Yadi |e verfasserin |4 aut | |
| 700 | 1 | |a Luo, Zilin |e verfasserin |4 aut | |
| 700 | 1 | |a Xu, Yongjie |e verfasserin |4 aut | |
| 700 | 1 | |a Zhao, Liang |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Jibin |e verfasserin |4 aut | |
| 700 | 1 | |a Zou, Kaiyong |e verfasserin |4 aut | |
| 700 | 1 | |a Cao, Wei |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Fei |e verfasserin |4 aut | |
| 700 | 1 | |a Ren, Jiansong |e verfasserin |4 aut | |
| 700 | 1 | |a Shi, Jufang |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Wanqing |e verfasserin |4 aut | |
| 700 | 1 | |a He, Jie |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Ni |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Chest |d 1970 |g (2024) vom: 20. Jan. |w (DE-627)NLM000002720 |x 1931-3543 |7 nnns |
| 773 | 1 | 8 | |g year:2024 |g day:20 |g month:01 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.chest.2024.01.031 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |j 2024 |b 20 |c 01 | ||