Pretransplant hepatomegaly is linked to relapse in patients with leukemia and myelodysplastic syndrome not in remission
© 2024. Japanese Society of Hematology..
Hepatomegaly is an extramedullary disease (EMD) manifestation of hematological malignancy. Although EMD before allogeneic hematopoietic stem cell transplantation (allo-HCT) is a risk factor for relapse in patients not in complete remission (NonCR) patients, the significance of hepatomegaly to allo-HCT is unclear. We conducted a single-center retrospective observational study of 140 patients with acute leukemia and myelodysplastic syndrome who underwent allo-HCT at our institution from 2014 to 2019. Hepatomegaly was assessed by ultrasonography using the liver index (LI). In the univariable analysis, the LI/height ratio was significantly associated with relapse (hazard ratio [HR] per standard deviation [sd]: 1.51, 95% confidence interval [CI] 1.18-1.93, p = 0.001, sd = 13.8) in NonCR patients (n = 62), but showed no significant association in CR patients (n = 78) (HR per sd: 0.95, 95% CI 0.64-1.39, p = 0.780, sd = 8.7). In multivariable analysis, the LI/height ratio was significantly associated with relapse (HR per sd: 1.34, 95% CI 1.02-1.78, p = 0.037) after adjusting for the refined disease risk index and conditioning intensity. Interaction analysis showed a noteworthy but not statistically significant association between the LI/height ratio and CR status (p = 0.110). In conclusion, our findings suggest that the LI may be a risk factor for relapse in NonCR patients after allo-HCT.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:119 |
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| Enthalten in: |
International journal of hematology - 119(2024), 3 vom: 07. März, Seite 316-326 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Okayama, Yusuke [VerfasserIn] |
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| Links: |
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| Themen: |
Journal Article |
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| Anmerkungen: |
Date Completed 08.03.2024 Date Revised 08.03.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1007/s12185-023-03707-7 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM367427338 |
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| 520 | |a Hepatomegaly is an extramedullary disease (EMD) manifestation of hematological malignancy. Although EMD before allogeneic hematopoietic stem cell transplantation (allo-HCT) is a risk factor for relapse in patients not in complete remission (NonCR) patients, the significance of hepatomegaly to allo-HCT is unclear. We conducted a single-center retrospective observational study of 140 patients with acute leukemia and myelodysplastic syndrome who underwent allo-HCT at our institution from 2014 to 2019. Hepatomegaly was assessed by ultrasonography using the liver index (LI). In the univariable analysis, the LI/height ratio was significantly associated with relapse (hazard ratio [HR] per standard deviation [sd]: 1.51, 95% confidence interval [CI] 1.18-1.93, p = 0.001, sd = 13.8) in NonCR patients (n = 62), but showed no significant association in CR patients (n = 78) (HR per sd: 0.95, 95% CI 0.64-1.39, p = 0.780, sd = 8.7). In multivariable analysis, the LI/height ratio was significantly associated with relapse (HR per sd: 1.34, 95% CI 1.02-1.78, p = 0.037) after adjusting for the refined disease risk index and conditioning intensity. Interaction analysis showed a noteworthy but not statistically significant association between the LI/height ratio and CR status (p = 0.110). In conclusion, our findings suggest that the LI may be a risk factor for relapse in NonCR patients after allo-HCT | ||
| 650 | 4 | |a Observational Study | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Liver index | |
| 650 | 4 | |a Noncomplete remission | |
| 650 | 4 | |a Pretransplant hepatomegaly | |
| 650 | 4 | |a Relapse | |
| 700 | 1 | |a Harada, Naonori |e verfasserin |4 aut | |
| 700 | 1 | |a Makuuchi, Yosuke |e verfasserin |4 aut | |
| 700 | 1 | |a Kuno, Masatomo |e verfasserin |4 aut | |
| 700 | 1 | |a Takakuwa, Teruhito |e verfasserin |4 aut | |
| 700 | 1 | |a Okamura, Hiroshi |e verfasserin |4 aut | |
| 700 | 1 | |a Hirose, Asao |e verfasserin |4 aut | |
| 700 | 1 | |a Nakamae, Mika |e verfasserin |4 aut | |
| 700 | 1 | |a Nishimoto, Mitsutaka |e verfasserin |4 aut | |
| 700 | 1 | |a Nakashima, Yasuhiro |e verfasserin |4 aut | |
| 700 | 1 | |a Koh, Hideo |e verfasserin |4 aut | |
| 700 | 1 | |a Hino, Masayuki |e verfasserin |4 aut | |
| 700 | 1 | |a Nakamae, Hirohisa |e verfasserin |4 aut | |
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