Antidepressant-induced Paradoxical Anxiety, Akathisia, and Complex Vocal Tics in a Patient with Panic Disorder and Crohn's Disease : A Case Report

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BACKGROUND: Antidepressant-induced paradoxical anxiety is a fairly common phenomenon seen in patients who are initiated on antidepressants. However, akathisia is a very uncommon manifestation of antidepressants. Much more rarely, antidepressants are also associated with the emergence of motor and vocal tics. This case adds to the growing literature of rare adverse events induced by antidepressants and aims to stimulate future research into the mechanism and risk factors of this phenomenon.

CASE PRESENTATION: In this case report, we describe a patient with panic disorder and co-morbid Crohn's disease who developed worsening anxiety, akathisia and vocal tics upon initiation of fluvoxamine. This is the first case report to describe the emergence of both akathisia and vocal tics in the same patient following antidepressant initiation. After discontinuation of fluvoxamine, the patient's symptoms resolved.

CONCLUSION: Antidepressant-induced akathisia and tics are often distressing both to the patient and their loved ones, and they can be very puzzling to the clinician. It is important for clinicians to recognise that, although rare, antidepressants can have the adverse effects of akathisia and tics in patients. When these symptoms arise, it should prompt immediate discontinuation of the offending antidepressant.

Medienart:

E-Artikel

Erscheinungsjahr:

2024

Erschienen:

2024

Enthalten in:

Zur Gesamtaufnahme - year:2024

Enthalten in:

Current drug safety - (2024) vom: 19. Jan.

Sprache:

Englisch

Beteiligte Personen:

Hk Koh, Azriel [VerfasserIn]
Loh, Soon Shan [VerfasserIn]
Lim, Leslie [VerfasserIn]

Links:

Volltext

Themen:

Akathisia
Antidepressant
Case Reports
Case report.
Fluvoxamine
Paradoxical anxiety
Tics

Anmerkungen:

Date Revised 22.01.2024

published: Print-Electronic

Citation Status Publisher

doi:

10.2174/0115748863270093231114075934

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM367421895