Validation of Quantitative Flow Ratio-Derived Virtual Angioplasty with Post-Angioplasty Fractional Flow Reserve-The QIMERA-I Study
Background: Quantitative flow ratio (QFR) virtual angioplasty with pre-PCI residual QFR showed better results compared with an angiographic approach to assess post-PCI functional results. However, correlation with pre-PCI residual QFR and post-PCI fractional flow reserve (FFR) is lacking. Methods: A multicenter prospective study including consecutive patients with angiographically 50-90% coronary lesions and positive QFR results. All patients were evaluated with QFR, hyperemic and non-hyperemic pressure ratios (NHPR) before and after the index PCI. Pre-PCI residual QFR (virtual angioplasty) was calculated and compared with post-PCI fractional flow reserve (FFR), QFR and NHPR. Results: A total of 84 patients with 92 treated coronary lesions were included, with a mean age of 65.5 ± 10.9 years and 59% of single vessel lesions being the left anterior descending artery in 69%. The mean vessel diameter was 2.82 ± 0.41 mm. Procedural success was achieved in all cases, with a mean number of implanted stents of 1.17 ± 0.46. The baseline QFR value was 0.69 ± 0.12 and baseline FFR and NHPR were 0.73 ± 0.08 and 0.82 ± 0.11, respectively. Mean post-PCI FFR increased to 0.87 ± 0.05 whereas residual QFR had been estimated as 0.95 ± 0.05, showing poor correlation with post-PCI FFR (0.163; 95% CI:0.078-0.386) and low diagnostic accuracy (30.9%, 95% CI:20-43%). Conclusions: In this analysis, the results of QFR-based virtual angioplasty did not seem to accurately correlate with post-PCI FFR.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:11 |
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| Enthalten in: |
Journal of cardiovascular development and disease - 11(2023), 1 vom: 31. Dez. |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Amat-Santos, Ignacio J [VerfasserIn] |
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| Links: |
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| Themen: |
Coronary physiology |
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| Anmerkungen: |
Date Revised 28.01.2024 published: Electronic Citation Status PubMed-not-MEDLINE |
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| doi: |
10.3390/jcdd11010014 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM367393778 |
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| 245 | 1 | 0 | |a Validation of Quantitative Flow Ratio-Derived Virtual Angioplasty with Post-Angioplasty Fractional Flow Reserve-The QIMERA-I Study |
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| 520 | |a Background: Quantitative flow ratio (QFR) virtual angioplasty with pre-PCI residual QFR showed better results compared with an angiographic approach to assess post-PCI functional results. However, correlation with pre-PCI residual QFR and post-PCI fractional flow reserve (FFR) is lacking. Methods: A multicenter prospective study including consecutive patients with angiographically 50-90% coronary lesions and positive QFR results. All patients were evaluated with QFR, hyperemic and non-hyperemic pressure ratios (NHPR) before and after the index PCI. Pre-PCI residual QFR (virtual angioplasty) was calculated and compared with post-PCI fractional flow reserve (FFR), QFR and NHPR. Results: A total of 84 patients with 92 treated coronary lesions were included, with a mean age of 65.5 ± 10.9 years and 59% of single vessel lesions being the left anterior descending artery in 69%. The mean vessel diameter was 2.82 ± 0.41 mm. Procedural success was achieved in all cases, with a mean number of implanted stents of 1.17 ± 0.46. The baseline QFR value was 0.69 ± 0.12 and baseline FFR and NHPR were 0.73 ± 0.08 and 0.82 ± 0.11, respectively. Mean post-PCI FFR increased to 0.87 ± 0.05 whereas residual QFR had been estimated as 0.95 ± 0.05, showing poor correlation with post-PCI FFR (0.163; 95% CI:0.078-0.386) and low diagnostic accuracy (30.9%, 95% CI:20-43%). Conclusions: In this analysis, the results of QFR-based virtual angioplasty did not seem to accurately correlate with post-PCI FFR | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a coronary physiology | |
| 650 | 4 | |a fractional flow reserve | |
| 650 | 4 | |a quantitative flow ratio | |
| 650 | 4 | |a virtual angioplasty | |
| 700 | 1 | |a Marengo, Giorgio |e verfasserin |4 aut | |
| 700 | 1 | |a Sánchez-Luna, Juan Pablo |e verfasserin |4 aut | |
| 700 | 1 | |a Cortés Villar, Carlos |e verfasserin |4 aut | |
| 700 | 1 | |a Rivero Crespo, Fernando |e verfasserin |4 aut | |
| 700 | 1 | |a Jiménez Díaz, Víctor Alfonso |e verfasserin |4 aut | |
| 700 | 1 | |a de la Torre Hernández, José María |e verfasserin |4 aut | |
| 700 | 1 | |a Pérez de Prado, Armando |e verfasserin |4 aut | |
| 700 | 1 | |a Sabaté, Manel |e verfasserin |4 aut | |
| 700 | 1 | |a López-Palop, Ramón |e verfasserin |4 aut | |
| 700 | 1 | |a Vegas Valle, José Miguel |e verfasserin |4 aut | |
| 700 | 1 | |a Suárez de Lezo, Javier |e verfasserin |4 aut | |
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