Incidence and risk factors of COVID-19 in a tertiary hospital and the effectiveness of booster vaccination among health care workers : A retrospective cohort study, January 2020 to June 2022
Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved..
BACKGROUND: Health care workers (HCWs) face a higher risk of infection and may transmit pathogens to patients during a pandemic. This study aims to evaluate infection-control measures by analyzing the incidence and risk factors of COVID-19 and estimating vaccine effectiveness (VE) at a tertiary hospital in Seoul, Republic of Korea.
METHODS: This study included 2,516 HCWs from January 1, 2020, to June 30, 2022. Data were analyzed to determine the incidence density and cumulative incidence; the results were compared by the age- and gender-specific standardized incidence ratios (SIR). VE was estimated with multivariate Cox proportional-hazard models as 1-adjusted hazard ratio × 100%.
RESULTS: SIR indicated a lower COVID-19 risk in the hospital population than in the general Korean population (SIR, 0.81; 95% confidence interval [CI]: 0.76-0.87). Multivariate Cox analysis indicated that, compared to doctors, nonmedical service supporters and other HCWs (excluding doctors and nurses) were high-risk groups (adjusted hazard ratio [95% CI], 1.72 [1.04-2.83] and 1.76 [1.20-2.58], respectively). Compared to the outpatient unit, the emergency department was a high-risk department (1.70 [1.16-2.50]). The VE of the booster dose was 55.47%, compared to no or incomplete vaccination (95% CI: 22.63-74.37).
CONCLUSIONS: Besides encouraging HCWs vaccination, effective infection-control measures should target high-risk groups and departments.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2024 |
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| Enthalten in: |
American journal of infection control - (2024) vom: 19. Jan. |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Lee, Hae Ry [VerfasserIn] |
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| Links: |
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| Themen: |
Emerging infectious diseases |
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| Anmerkungen: |
Date Revised 16.02.2024 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.1016/j.ajic.2024.01.010 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM367369907 |
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| 100 | 1 | |a Lee, Hae Ry |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Incidence and risk factors of COVID-19 in a tertiary hospital and the effectiveness of booster vaccination among health care workers |b A retrospective cohort study, January 2020 to June 2022 |
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| 500 | |a Date Revised 16.02.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status Publisher | ||
| 520 | |a Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved. | ||
| 520 | |a BACKGROUND: Health care workers (HCWs) face a higher risk of infection and may transmit pathogens to patients during a pandemic. This study aims to evaluate infection-control measures by analyzing the incidence and risk factors of COVID-19 and estimating vaccine effectiveness (VE) at a tertiary hospital in Seoul, Republic of Korea | ||
| 520 | |a METHODS: This study included 2,516 HCWs from January 1, 2020, to June 30, 2022. Data were analyzed to determine the incidence density and cumulative incidence; the results were compared by the age- and gender-specific standardized incidence ratios (SIR). VE was estimated with multivariate Cox proportional-hazard models as 1-adjusted hazard ratio × 100% | ||
| 520 | |a RESULTS: SIR indicated a lower COVID-19 risk in the hospital population than in the general Korean population (SIR, 0.81; 95% confidence interval [CI]: 0.76-0.87). Multivariate Cox analysis indicated that, compared to doctors, nonmedical service supporters and other HCWs (excluding doctors and nurses) were high-risk groups (adjusted hazard ratio [95% CI], 1.72 [1.04-2.83] and 1.76 [1.20-2.58], respectively). Compared to the outpatient unit, the emergency department was a high-risk department (1.70 [1.16-2.50]). The VE of the booster dose was 55.47%, compared to no or incomplete vaccination (95% CI: 22.63-74.37) | ||
| 520 | |a CONCLUSIONS: Besides encouraging HCWs vaccination, effective infection-control measures should target high-risk groups and departments | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Emerging infectious diseases | |
| 650 | 4 | |a Infection control | |
| 650 | 4 | |a SARS-CoV-2 | |
| 650 | 4 | |a Vaccine effectiveness | |
| 700 | 1 | |a Kim, Sung Ran |e verfasserin |4 aut | |
| 700 | 1 | |a Cho, Min Hee |e verfasserin |4 aut | |
| 700 | 1 | |a Kim, Da Eun |e verfasserin |4 aut | |
| 700 | 1 | |a Jang, Su Yeon |e verfasserin |4 aut | |
| 700 | 1 | |a Lee, Jae Eun |e verfasserin |4 aut | |
| 700 | 1 | |a Jeong, Hye Rin |e verfasserin |4 aut | |
| 700 | 1 | |a Kang, Hyeon Jeong |e verfasserin |4 aut | |
| 700 | 1 | |a Song, Joon Young |e verfasserin |4 aut | |
| 700 | 1 | |a Chun, Byung Chul |e verfasserin |4 aut | |
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