Reorganization of Brain Resting-state Functional Connectivity Following 14 Days of Elbow Immobilization in Young Females
Copyright © 2024 IBRO. Published by Elsevier Inc. All rights reserved..
Limb immobilization is known to cause significant decreases in muscle strength and muscle mass as early as two days following the onset of immobilization. However, the decline in strength surpasses the decline in muscle mass, suggesting that factors in addition to muscle loss, such as neuroplasticity, contribute to the decrease in force production. However, little is known regarding immobilization-induced neural changes, although sensorimotor regions seem to be the most affected. The present study aimed to determine whether brain functional organization is altered following 14 days of unilateral elbow immobilization. Functional organization was quantified using resting-state functional connectivity, a measure of the synchronicity of the spontaneous discharge of different brain regions at rest. Data was obtained from twelve healthy young females before and after completing the immobilization period. A seed-to-voxel analysis was performed using seeds associated with cortical, subcortical, and cerebellar sensorimotor regions of the brain. The results showed changes predominantly involving cerebellar connectivity. For example, the immobilization period caused a decrease in connectivity between the motor cerebellar region of the immobilized arm and the left temporal lobe, and an increase between the same cerebellar region and the supplementary motor area. Overall, changes in connectivity occurred in regions typically associated with error detection and motor learning, suggesting a potential functional reorganization of the brain within 14 days of elbow immobilization.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:540 |
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| Enthalten in: |
Neuroscience - 540(2024) vom: 05. Feb., Seite 77-86 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Clouette, Julien [VerfasserIn] |
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| Links: |
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| Themen: |
Female |
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| Anmerkungen: |
Date Completed 29.02.2024 Date Revised 29.02.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.neuroscience.2024.01.005 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM367369664 |
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| 520 | |a Copyright © 2024 IBRO. Published by Elsevier Inc. All rights reserved. | ||
| 520 | |a Limb immobilization is known to cause significant decreases in muscle strength and muscle mass as early as two days following the onset of immobilization. However, the decline in strength surpasses the decline in muscle mass, suggesting that factors in addition to muscle loss, such as neuroplasticity, contribute to the decrease in force production. However, little is known regarding immobilization-induced neural changes, although sensorimotor regions seem to be the most affected. The present study aimed to determine whether brain functional organization is altered following 14 days of unilateral elbow immobilization. Functional organization was quantified using resting-state functional connectivity, a measure of the synchronicity of the spontaneous discharge of different brain regions at rest. Data was obtained from twelve healthy young females before and after completing the immobilization period. A seed-to-voxel analysis was performed using seeds associated with cortical, subcortical, and cerebellar sensorimotor regions of the brain. The results showed changes predominantly involving cerebellar connectivity. For example, the immobilization period caused a decrease in connectivity between the motor cerebellar region of the immobilized arm and the left temporal lobe, and an increase between the same cerebellar region and the supplementary motor area. Overall, changes in connectivity occurred in regions typically associated with error detection and motor learning, suggesting a potential functional reorganization of the brain within 14 days of elbow immobilization | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Female | |
| 650 | 4 | |a Limb immobilization | |
| 650 | 4 | |a Resting-state functional connectivity | |
| 700 | 1 | |a Potvin-Desrochers, Alexandra |e verfasserin |4 aut | |
| 700 | 1 | |a Seo, Freddie |e verfasserin |4 aut | |
| 700 | 1 | |a Churchward-Venne, Tyler A |e verfasserin |4 aut | |
| 700 | 1 | |a Paquette, Caroline |e verfasserin |4 aut | |
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