Increased ACE2 and TMPRSS2 expression in ulcerative colitis
Copyright © 2024 Elsevier GmbH. All rights reserved..
Ulcerative colitis (UC) is a cryptogenic inflammatory bowel disease, and there is an urgent need to elucidate its pathogenesis. ACE2 and TMPRSS2, the entry molecules of SARS-CoV-2, are reportedly associated with the disease; however, no consensus has been reached yet. In this study, we examined the expression of ACE2 and TMPRSS2 in colon and rectal specimens of UC. We collected colorectal specimens from 60 patients (30 patients with UC and 30 controls from 2018 to 2021) and analyzed the proportion and intensity of ACE2 and TMPRSS2 using immunohistochemistry. The results revealed a significant increase in the proportion of ACE2 expression and the intensity of TMPRSS2 expression in patients with UC. ACE2 and TMPRSS2 expression in UC remained unaffected by the COVID-19 pandemic. We demonstrated that ACE2 and TMPRSS2 are likely involved in the pathogenesis of UC.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:254 |
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| Enthalten in: |
Pathology, research and practice - 254(2024) vom: 01. Feb., Seite 155108 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Hamamoto, Yuichiro [VerfasserIn] |
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| Links: |
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| Themen: |
ACE2 |
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| Anmerkungen: |
Date Completed 14.02.2024 Date Revised 14.02.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.prp.2024.155108 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM367365294 |
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| 520 | |a Ulcerative colitis (UC) is a cryptogenic inflammatory bowel disease, and there is an urgent need to elucidate its pathogenesis. ACE2 and TMPRSS2, the entry molecules of SARS-CoV-2, are reportedly associated with the disease; however, no consensus has been reached yet. In this study, we examined the expression of ACE2 and TMPRSS2 in colon and rectal specimens of UC. We collected colorectal specimens from 60 patients (30 patients with UC and 30 controls from 2018 to 2021) and analyzed the proportion and intensity of ACE2 and TMPRSS2 using immunohistochemistry. The results revealed a significant increase in the proportion of ACE2 expression and the intensity of TMPRSS2 expression in patients with UC. ACE2 and TMPRSS2 expression in UC remained unaffected by the COVID-19 pandemic. We demonstrated that ACE2 and TMPRSS2 are likely involved in the pathogenesis of UC | ||
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| 650 | 4 | |a COVID-19 | |
| 650 | 4 | |a Inflammatory bowel disease | |
| 650 | 4 | |a SARS-CoV-2 | |
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| 700 | 1 | |a Uchida, Hiroki |e verfasserin |4 aut | |
| 700 | 1 | |a Hiramatsu, Kazuhiro |e verfasserin |4 aut | |
| 700 | 1 | |a Katori, Chiaki |e verfasserin |4 aut | |
| 700 | 1 | |a Asai, Hinako |e verfasserin |4 aut | |
| 700 | 1 | |a Egawa, Satoshi |e verfasserin |4 aut | |
| 700 | 1 | |a Yoshida, Kyotaro |e verfasserin |4 aut | |
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