Polystyrene microplastics effects on zebrafish embryological development : Comparison of two different sizes
Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved..
Microplastics have become a great worldwide problem and it's therefore important to study their possible effects on human and environmental health. In this study, zebrafish embryos were used to compare two different sizes of polystyrene microplastics (PS-MPs), 1 µm and 3 µm respectively, at 0.01, 0.1, 1.0 and 10.0 mgL-1, and were monitored up to 72 h. Toxicity tests demonstrated that neither of the PS-MPs altered the embryos' survival and the normal hatching process. Instead, higher concentrations of both sizes caused an increase of the heart rate and phenotypic changes. The PS-MPs of both sizes entered and accumulated in the larvae at the concentration of 10.0 mgL-1 and the same concentration caused an increase of apoptotic processes correlated to redox homeostasis changes. The reported results give a realistic view of the negative effects of exposure to PS-MPs and provide new information on their toxicity, also considering their sizes.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:106 |
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| Enthalten in: |
Environmental toxicology and pharmacology - 106(2024) vom: 01. März, Seite 104371 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
La Pietra, Alessandra [VerfasserIn] |
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| Links: |
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| Themen: |
Apoptosis |
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| Anmerkungen: |
Date Completed 04.03.2024 Date Revised 04.03.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.etap.2024.104371 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
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| 520 | |a Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved. | ||
| 520 | |a Microplastics have become a great worldwide problem and it's therefore important to study their possible effects on human and environmental health. In this study, zebrafish embryos were used to compare two different sizes of polystyrene microplastics (PS-MPs), 1 µm and 3 µm respectively, at 0.01, 0.1, 1.0 and 10.0 mgL-1, and were monitored up to 72 h. Toxicity tests demonstrated that neither of the PS-MPs altered the embryos' survival and the normal hatching process. Instead, higher concentrations of both sizes caused an increase of the heart rate and phenotypic changes. The PS-MPs of both sizes entered and accumulated in the larvae at the concentration of 10.0 mgL-1 and the same concentration caused an increase of apoptotic processes correlated to redox homeostasis changes. The reported results give a realistic view of the negative effects of exposure to PS-MPs and provide new information on their toxicity, also considering their sizes | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Apoptosis | |
| 650 | 4 | |a Cardiotoxicity | |
| 650 | 4 | |a Embryotoxicity | |
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| 650 | 4 | |a Oxidative stress | |
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| 700 | 1 | |a Lucariello, Daniela |e verfasserin |4 aut | |
| 700 | 1 | |a Motta, Chiara Maria |e verfasserin |4 aut | |
| 700 | 1 | |a Venditti, Paola |e verfasserin |4 aut | |
| 700 | 1 | |a Ferrandino, Ida |e verfasserin |4 aut | |
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