Clinical Results and Hematologic Predictors of Linear Accelerator-Based Stereotactic Radiosurgery or Fractionated Stereotactic Radiotherapy for Brain Metastasis in Patients Aged 75 Years or Older : A Retrospective Study
Copyright © 2024 Elsevier Inc. All rights reserved..
OBJECTIVE: This study aimed to evaluate prognostic factors including pre-radiosurgical blood count in elderly patients (EPs) with brain metastasis (BM) who were treated using linear accelerator (LINAC)-based stereotactic radiosurgery (SRS) and fractionated stereotactic radiotherapy (fSRT) with a micro-multileaf collimator.
METHODS: Between January 2011 and November 2021, 101 consecutive EPs with BM were treated by LINAC-based SRS or fSRT using LINAC with a micro-multileaf collimator. EPs were defined as patients aged ≥75 years.
RESULTS: The tumors originated from the lungs (n = 90; 89.1%), colon (n = 2; 2.0%), and others (n = 9; 8.8%) in these EPs. The median pretreatment Karnofsky Performance Status was 80 (range, 40-100). The median follow-up time was 10 months (range, 0-76), as was the median survival. The 6-month, 1-year, and 2-year survival in the EP group was 58.3%, 43.2%, and 28.5%, respectively. Freedom from local failure at 6 months and 1 and 2 years was 97%, 95%, and 91.5%, respectively. Freedom from distant failure at 6 months and 1 and 2 years in EPs was 70.6%, 59.4%, and 54.2%, respectively. A high neutrophil/lymphocyte ratio >5.33 was an unfavorable predictor of prognosis for EPs with BMs treated with SRS and fSRT (P < 0.001). In the EPs, the prognostic factors associated with prolonged survival in the Cox proportional hazards model were being female and a good pretreatment Karnofsky Performance Status.
CONCLUSIONS: The findings of our study highlight the efficacy of LINAC-based SRS and fSRT with a micro-multileaf collimator in the treatment of EPs with BMs. Neutrophil/lymphocyte ratio can be an important factor in treatment decisions for EPs with BMs.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:183 |
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| Enthalten in: |
World neurosurgery - 183(2024) vom: 27. März, Seite e944-e952 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Matsuda, Ryosuke [VerfasserIn] |
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| Links: |
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| Themen: |
Brain metastasis |
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| Anmerkungen: |
Date Completed 13.03.2024 Date Revised 13.03.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.wneu.2024.01.069 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM367351749 |
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| 100 | 1 | |a Matsuda, Ryosuke |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Clinical Results and Hematologic Predictors of Linear Accelerator-Based Stereotactic Radiosurgery or Fractionated Stereotactic Radiotherapy for Brain Metastasis in Patients Aged 75 Years or Older |b A Retrospective Study |
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| 500 | |a Date Completed 13.03.2024 | ||
| 500 | |a Date Revised 13.03.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2024 Elsevier Inc. All rights reserved. | ||
| 520 | |a OBJECTIVE: This study aimed to evaluate prognostic factors including pre-radiosurgical blood count in elderly patients (EPs) with brain metastasis (BM) who were treated using linear accelerator (LINAC)-based stereotactic radiosurgery (SRS) and fractionated stereotactic radiotherapy (fSRT) with a micro-multileaf collimator | ||
| 520 | |a METHODS: Between January 2011 and November 2021, 101 consecutive EPs with BM were treated by LINAC-based SRS or fSRT using LINAC with a micro-multileaf collimator. EPs were defined as patients aged ≥75 years | ||
| 520 | |a RESULTS: The tumors originated from the lungs (n = 90; 89.1%), colon (n = 2; 2.0%), and others (n = 9; 8.8%) in these EPs. The median pretreatment Karnofsky Performance Status was 80 (range, 40-100). The median follow-up time was 10 months (range, 0-76), as was the median survival. The 6-month, 1-year, and 2-year survival in the EP group was 58.3%, 43.2%, and 28.5%, respectively. Freedom from local failure at 6 months and 1 and 2 years was 97%, 95%, and 91.5%, respectively. Freedom from distant failure at 6 months and 1 and 2 years in EPs was 70.6%, 59.4%, and 54.2%, respectively. A high neutrophil/lymphocyte ratio >5.33 was an unfavorable predictor of prognosis for EPs with BMs treated with SRS and fSRT (P < 0.001). In the EPs, the prognostic factors associated with prolonged survival in the Cox proportional hazards model were being female and a good pretreatment Karnofsky Performance Status | ||
| 520 | |a CONCLUSIONS: The findings of our study highlight the efficacy of LINAC-based SRS and fSRT with a micro-multileaf collimator in the treatment of EPs with BMs. Neutrophil/lymphocyte ratio can be an important factor in treatment decisions for EPs with BMs | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Brain metastasis | |
| 650 | 4 | |a Elderly patients | |
| 650 | 4 | |a LINAC with a micro-multileaf collimator | |
| 650 | 4 | |a Neutrophil/lymphocyte | |
| 650 | 4 | |a Stereotactic radiosurgery | |
| 650 | 4 | |a Stereotactic radiotherapy | |
| 700 | 1 | |a Hasegawa, Masatoshi |e verfasserin |4 aut | |
| 700 | 1 | |a Tamamoto, Tetsuro |e verfasserin |4 aut | |
| 700 | 1 | |a Inooka, Nobuyoshi |e verfasserin |4 aut | |
| 700 | 1 | |a Morimoto, Takayuki |e verfasserin |4 aut | |
| 700 | 1 | |a Maeoka, Ryosuke |e verfasserin |4 aut | |
| 700 | 1 | |a Nakazawa, Tsutomu |e verfasserin |4 aut | |
| 700 | 1 | |a Ochi, Tomoko |e verfasserin |4 aut | |
| 700 | 1 | |a Miyasaka, Toshiteru |e verfasserin |4 aut | |
| 700 | 1 | |a Hontsu, Shigeto |e verfasserin |4 aut | |
| 700 | 1 | |a Yamaki, Kaori |e verfasserin |4 aut | |
| 700 | 1 | |a Miura, Sachiko |e verfasserin |4 aut | |
| 700 | 1 | |a Yamada, Shuichi |e verfasserin |4 aut | |
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| 700 | 1 | |a Nakagawa, Ichiro |e verfasserin |4 aut | |
| 700 | 1 | |a Park, Young-Soo |e verfasserin |4 aut | |
| 700 | 1 | |a Nakase, Hiroyuki |e verfasserin |4 aut | |
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