Updated Intrinsic Role of Phytochemicals against Glyphosate-induced Neurotoxicity : Systematic Review
Copyright© Bentham Science Publishers; For any queries, please email at epubbenthamscience.net..
BACKGROUND: Glyphosate-based herbicide (GBH) formulations are organophosphorus pesticides implicated for agricultural use. Several epidemiological reports have reported that the occupational exposure of farmers to glyphosate can cause age-related neurodegeneration.
OBJECTIVE: the objective of this study is to examine the neurotoxic effects of glyphosate and its intricate role in triggering several neurodegenerative diseases like dementia, nootropic defects, Parkinson's disease, and neurological teratogenic effects due to its negative effects on the nervous system. Furthermore, the efficacy of phytochemicals against glyphosate-induced neurotoxicity was discussed.
METHODS: We have searched public databases such as NLM, Pubmed, google scholar and collected a total of 103 articles including reviews, original articles, and obtained information related to glyphosate-induced neurotoxicity and novel phytochemicals implicated to ameliorate the glyphosate-induced neurotoxicity. We performed a systematic review without comprehensive meta-analysis.
RESULTS: the efficacy of several phytochemicals as a nutritional intervention against glyphosate-induced neurotoxicity including Parkinsonism was elucidated by vivid review analysis of neurobehavioral alterations from in vitro and in vivo study models.
CONCLUSION: These kinds of research projects will bring awareness about the neurotoxic effects of glyphosate and the protective nutritional intervention strategies against glyphosate-induced neurotoxicity including Parkinsonism for farmers.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2024 |
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| Enthalten in: |
Current medicinal chemistry - (2024) vom: 12. Jan. |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Fan, Ruitai [VerfasserIn] |
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| Links: |
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| Themen: |
Glutamate toxicity |
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| Anmerkungen: |
Date Revised 20.01.2024 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.2174/0109298673257171231115114543 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM367344750 |
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| 500 | |a Date Revised 20.01.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status Publisher | ||
| 520 | |a Copyright© Bentham Science Publishers; For any queries, please email at epubbenthamscience.net. | ||
| 520 | |a BACKGROUND: Glyphosate-based herbicide (GBH) formulations are organophosphorus pesticides implicated for agricultural use. Several epidemiological reports have reported that the occupational exposure of farmers to glyphosate can cause age-related neurodegeneration | ||
| 520 | |a OBJECTIVE: the objective of this study is to examine the neurotoxic effects of glyphosate and its intricate role in triggering several neurodegenerative diseases like dementia, nootropic defects, Parkinson's disease, and neurological teratogenic effects due to its negative effects on the nervous system. Furthermore, the efficacy of phytochemicals against glyphosate-induced neurotoxicity was discussed | ||
| 520 | |a METHODS: We have searched public databases such as NLM, Pubmed, google scholar and collected a total of 103 articles including reviews, original articles, and obtained information related to glyphosate-induced neurotoxicity and novel phytochemicals implicated to ameliorate the glyphosate-induced neurotoxicity. We performed a systematic review without comprehensive meta-analysis | ||
| 520 | |a RESULTS: the efficacy of several phytochemicals as a nutritional intervention against glyphosate-induced neurotoxicity including Parkinsonism was elucidated by vivid review analysis of neurobehavioral alterations from in vitro and in vivo study models | ||
| 520 | |a CONCLUSION: These kinds of research projects will bring awareness about the neurotoxic effects of glyphosate and the protective nutritional intervention strategies against glyphosate-induced neurotoxicity including Parkinsonism for farmers | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Glyphosate-based herbicide | |
| 650 | 4 | |a glutamate toxicity | |
| 650 | 4 | |a neurodegeneration | |
| 650 | 4 | |a organophosphorus | |
| 650 | 4 | |a parkinsonism | |
| 650 | 4 | |a pesticides | |
| 700 | 1 | |a Zheng, Yufei |e verfasserin |4 aut | |
| 700 | 1 | |a Yn, Lakshmi Durga |e verfasserin |4 aut | |
| 700 | 1 | |a Beeraka, Narasimha M |e verfasserin |4 aut | |
| 700 | 1 | |a Vikram P R, Hemanth |e verfasserin |4 aut | |
| 700 | 1 | |a Suhail, Shaik Mohammed |e verfasserin |4 aut | |
| 700 | 1 | |a Manjula, Santhepete N |e verfasserin |4 aut | |
| 700 | 1 | |a Bannimath, Namitha |e verfasserin |4 aut | |
| 700 | 1 | |a Sinelnikov, Mikhail Y |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Junqi |e verfasserin |4 aut | |
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