A microbial risk assessor's guide to Valley Fever (Coccidioides spp.) : Case study and review of risk factors
Copyright © 2024 Elsevier B.V. All rights reserved..
Valley Fever is a respiratory disease caused by inhalation of arthroconidia, a type of spore produced by fungi within the genus Coccidioides spp. which are found in dry, hot ecosystems of the Western Hemisphere. A quantitative microbial risk assessment (QMRA) for the disease has not yet been performed due to a lack of dose-response models and a scarcity of quantitative occurrence data from environmental samples. A literature review was performed to gather data on experimental animal dosing studies, environmental occurrence, human disease outbreaks, and meteorological associations. As a result, a risk framework is presented with information for parameterizing QMRA models for Coccidioides spp., with eight new dose-response models proposed. A probabilistic QMRA was conducted for a Southwestern US agricultural case study, evaluating eight scenarios related to farming occupational exposures. Median daily workday risks for developing severe Valley Fever ranged from 2.53 × 10-7 (planting by hand while wearing an N95 facemask) to 1.33 × 10-3 (machine harvesting while not wearing a facemask). The literature review and QMRA synthesis confirmed that exposure to aerosolized arthroconidia has the potential to result in high attack rates but highlighted that the mechanistic relationships between environmental conditions and disease remain poorly understood. Recommendations for Valley Fever risk assessment research needs in order to reduce disease risks are discussed, including interventions for farmers.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2024 |
|---|---|
| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:917 |
|---|---|
| Enthalten in: |
The Science of the total environment - 917(2024) vom: 20. März, Seite 170141 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Kahn, David [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
C. immitis |
|---|
| Anmerkungen: |
Date Completed 22.02.2024 Date Revised 09.03.2024 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1016/j.scitotenv.2024.170141 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM367329808 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM367329808 | ||
| 003 | DE-627 | ||
| 005 | 20240309232147.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240120s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.scitotenv.2024.170141 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1321.xml |
| 035 | |a (DE-627)NLM367329808 | ||
| 035 | |a (NLM)38242485 | ||
| 035 | |a (PII)S0048-9697(24)00275-4 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Kahn, David |e verfasserin |4 aut | |
| 245 | 1 | 2 | |a A microbial risk assessor's guide to Valley Fever (Coccidioides spp.) |b Case study and review of risk factors |
| 264 | 1 | |c 2024 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 22.02.2024 | ||
| 500 | |a Date Revised 09.03.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2024 Elsevier B.V. All rights reserved. | ||
| 520 | |a Valley Fever is a respiratory disease caused by inhalation of arthroconidia, a type of spore produced by fungi within the genus Coccidioides spp. which are found in dry, hot ecosystems of the Western Hemisphere. A quantitative microbial risk assessment (QMRA) for the disease has not yet been performed due to a lack of dose-response models and a scarcity of quantitative occurrence data from environmental samples. A literature review was performed to gather data on experimental animal dosing studies, environmental occurrence, human disease outbreaks, and meteorological associations. As a result, a risk framework is presented with information for parameterizing QMRA models for Coccidioides spp., with eight new dose-response models proposed. A probabilistic QMRA was conducted for a Southwestern US agricultural case study, evaluating eight scenarios related to farming occupational exposures. Median daily workday risks for developing severe Valley Fever ranged from 2.53 × 10-7 (planting by hand while wearing an N95 facemask) to 1.33 × 10-3 (machine harvesting while not wearing a facemask). The literature review and QMRA synthesis confirmed that exposure to aerosolized arthroconidia has the potential to result in high attack rates but highlighted that the mechanistic relationships between environmental conditions and disease remain poorly understood. Recommendations for Valley Fever risk assessment research needs in order to reduce disease risks are discussed, including interventions for farmers | ||
| 650 | 4 | |a Review | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a C. immitis | |
| 650 | 4 | |a C. posadasii meteorological factors | |
| 650 | 4 | |a Climate | |
| 650 | 4 | |a Coccidioides | |
| 650 | 4 | |a Coccidioidomycosis | |
| 650 | 4 | |a Valley fever | |
| 650 | 4 | |a Weather | |
| 700 | 1 | |a Chen, William |e verfasserin |4 aut | |
| 700 | 1 | |a Linden, Yarrow |e verfasserin |4 aut | |
| 700 | 1 | |a Corbeil, Karalee A |e verfasserin |4 aut | |
| 700 | 1 | |a Lowry, Sarah |e verfasserin |4 aut | |
| 700 | 1 | |a Higham, Ciara A |e verfasserin |4 aut | |
| 700 | 1 | |a Mendez, Karla S |e verfasserin |4 aut | |
| 700 | 1 | |a Burch, Paige |e verfasserin |4 aut | |
| 700 | 1 | |a DiFondi, Taylor |e verfasserin |4 aut | |
| 700 | 1 | |a Verhougstraete, Marc |e verfasserin |4 aut | |
| 700 | 1 | |a De Roos, Anneclaire J |e verfasserin |4 aut | |
| 700 | 1 | |a Haas, Charles N |e verfasserin |4 aut | |
| 700 | 1 | |a Gerba, Charles |e verfasserin |4 aut | |
| 700 | 1 | |a Hamilton, Kerry A |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t The Science of the total environment |d 1972 |g 917(2024) vom: 20. März, Seite 170141 |w (DE-627)NLM000215562 |x 1879-1026 |7 nnns |
| 773 | 1 | 8 | |g volume:917 |g year:2024 |g day:20 |g month:03 |g pages:170141 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.scitotenv.2024.170141 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 917 |j 2024 |b 20 |c 03 |h 170141 | ||