Allergic rhinitis phenotypes with distinct transcriptome profiles in children : A birth cohort
Copyright © 2024 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved..
BACKGROUND: Allergic rhinitis (AR) phenotypes in childhood are unclear.
OBJECTIVES: This study sought to determine AR phenotypes and investigate their natural course and clinical and transcriptomic characteristics.
METHODS: Latent class trajectory analysis was used for phenotyping AR in 1050 children from birth through 12 years using a birth cohort study. Blood transcriptome analyses were performed to define the underlying mechanisms of each phenotype.
RESULTS: Five AR phenotypes were identified: early onset (n = 88, 8.4%), intermediate transient (n = 110, 10.5%), late onset (n = 209, 19.9%), very late onset (n=187, 17.8%), and never/infrequent (n = 456, 43.4%). Children with early-onset AR were associated with higher AR severity and sensitizations to foods at age 1 year and inhalants at age 3 years and asthma symptoms, but not with bronchial hyperresponsiveness (BHR). Children with late-onset AR phenotype associated with sensitizations to various foods at age 1 year but not from age 3 years, and to inhalants from age 7 years and with asthma with BHR. Children with very late-onset AR phenotype associated with sensitizations to foods throughout preschool age and to inhalants at ages 7 and 9 years and with asthma with BHR. Transcriptome analysis showed that early-onset AR was associated with viral/bacterial infection-related defense response, whereas late-onset AR was associated with T cell-related immune response.
CONCLUSIONS: Early-onset AR phenotype was associated with sensitization to foods and inhalants at an early age and asthma symptoms, but not with BHR, whereas very late- and late-onset AR phenotypes were positively associated with sensitization to inhalants and asthma with BHR. Transcriptomic analyses indicated that early- and late-onset AR phenotypes had distinct underlying mechanisms related to AR as well.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2024 |
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| Enthalten in: |
The Journal of allergy and clinical immunology - (2024) vom: 17. Jan. |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Shin, Youn Ho [VerfasserIn] |
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| Links: |
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| Themen: |
Allergic rhinitis |
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| Anmerkungen: |
Date Revised 04.02.2024 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.1016/j.jaci.2023.12.024 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM367327082 |
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| 100 | 1 | |a Shin, Youn Ho |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Allergic rhinitis phenotypes with distinct transcriptome profiles in children |b A birth cohort |
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| 520 | |a Copyright © 2024 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved. | ||
| 520 | |a BACKGROUND: Allergic rhinitis (AR) phenotypes in childhood are unclear | ||
| 520 | |a OBJECTIVES: This study sought to determine AR phenotypes and investigate their natural course and clinical and transcriptomic characteristics | ||
| 520 | |a METHODS: Latent class trajectory analysis was used for phenotyping AR in 1050 children from birth through 12 years using a birth cohort study. Blood transcriptome analyses were performed to define the underlying mechanisms of each phenotype | ||
| 520 | |a RESULTS: Five AR phenotypes were identified: early onset (n = 88, 8.4%), intermediate transient (n = 110, 10.5%), late onset (n = 209, 19.9%), very late onset (n=187, 17.8%), and never/infrequent (n = 456, 43.4%). Children with early-onset AR were associated with higher AR severity and sensitizations to foods at age 1 year and inhalants at age 3 years and asthma symptoms, but not with bronchial hyperresponsiveness (BHR). Children with late-onset AR phenotype associated with sensitizations to various foods at age 1 year but not from age 3 years, and to inhalants from age 7 years and with asthma with BHR. Children with very late-onset AR phenotype associated with sensitizations to foods throughout preschool age and to inhalants at ages 7 and 9 years and with asthma with BHR. Transcriptome analysis showed that early-onset AR was associated with viral/bacterial infection-related defense response, whereas late-onset AR was associated with T cell-related immune response | ||
| 520 | |a CONCLUSIONS: Early-onset AR phenotype was associated with sensitization to foods and inhalants at an early age and asthma symptoms, but not with BHR, whereas very late- and late-onset AR phenotypes were positively associated with sensitization to inhalants and asthma with BHR. Transcriptomic analyses indicated that early- and late-onset AR phenotypes had distinct underlying mechanisms related to AR as well | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Allergic rhinitis | |
| 650 | 4 | |a children | |
| 650 | 4 | |a comorbidity | |
| 650 | 4 | |a phenotype | |
| 650 | 4 | |a trajectory | |
| 650 | 4 | |a transcriptome | |
| 700 | 1 | |a Kim, Jeong-Hyun |e verfasserin |4 aut | |
| 700 | 1 | |a Lee, Si-Hyeon |e verfasserin |4 aut | |
| 700 | 1 | |a Lee, So-Yeon |e verfasserin |4 aut | |
| 700 | 1 | |a Park, Yoon Mee |e verfasserin |4 aut | |
| 700 | 1 | |a Choi, Eum Ji |e verfasserin |4 aut | |
| 700 | 1 | |a Paek, Eun Young |e verfasserin |4 aut | |
| 700 | 1 | |a Song, Kun-Baek |e verfasserin |4 aut | |
| 700 | 1 | |a Park, Min Ji |e verfasserin |4 aut | |
| 700 | 1 | |a Jung, Sungsu |e verfasserin |4 aut | |
| 700 | 1 | |a Yoon, Jisun |e verfasserin |4 aut | |
| 700 | 1 | |a Suh, Dong In |e verfasserin |4 aut | |
| 700 | 1 | |a Kim, Kyung Won |e verfasserin |4 aut | |
| 700 | 1 | |a Ahn, Kangmo |e verfasserin |4 aut | |
| 700 | 1 | |a Hong, Soo-Jong |e verfasserin |4 aut | |
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