Association of Lipoprotein(a) with arterial stiffness : A Mendelian randomization study
© 2024 Stichting European Society for Clinical Investigation Journal Foundation. Published by John Wiley & Sons Ltd..
BACKGROUND: In this study we used Mendelian randomization (MR) to investigate the potential causal association of lipoprotein (a) [Lp(a)] levels with pulse wave velocity (PWV).
METHODS: Genetic variants associated with Lp(a) were retrieved from the UK Biobank GWAS (N = 290,497). A non- overlapping GWAS based on a European cohort (N = 7,000) was used to obtain genetic associations with PWV (outcome) and utilized two different measures for the same trait, brachial-ankle (baPWV) and carotid-femoral (cfPWV) PWV. We applied a two-sample MR using the inverse variance weighting method (IVW) and a series of sensitivity analyses for 170 SNPs that were selected as instrumental variables (IVs).
RESULTS: Our analyses do not support a causal association between Lp(a) and PWV for neither measurement [βiwv(baPWV) = -.0005, p = .8 and βiwv(cfPWV) = -.006, p = .16]. The above findings were consistent across sensitivity analyses including weighted median, mode-based estimation, MR-Egger regression and MR-PRESSO.
CONCLUSION: We did not find evidence indicating that Lp(a) is causally associated with PWV, the gold standard marker of arterial stiffness.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:54 |
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| Enthalten in: |
European journal of clinical investigation - 54(2024), 5 vom: 18. Apr., Seite e14168 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Simistiras, Alexandros [VerfasserIn] |
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| Links: |
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| Themen: |
Arterial stiffness |
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| Anmerkungen: |
Date Completed 17.04.2024 Date Revised 17.04.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1111/eci.14168 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM367295814 |
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| 500 | |a Date Revised 17.04.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2024 Stichting European Society for Clinical Investigation Journal Foundation. Published by John Wiley & Sons Ltd. | ||
| 520 | |a BACKGROUND: In this study we used Mendelian randomization (MR) to investigate the potential causal association of lipoprotein (a) [Lp(a)] levels with pulse wave velocity (PWV) | ||
| 520 | |a METHODS: Genetic variants associated with Lp(a) were retrieved from the UK Biobank GWAS (N = 290,497). A non- overlapping GWAS based on a European cohort (N = 7,000) was used to obtain genetic associations with PWV (outcome) and utilized two different measures for the same trait, brachial-ankle (baPWV) and carotid-femoral (cfPWV) PWV. We applied a two-sample MR using the inverse variance weighting method (IVW) and a series of sensitivity analyses for 170 SNPs that were selected as instrumental variables (IVs) | ||
| 520 | |a RESULTS: Our analyses do not support a causal association between Lp(a) and PWV for neither measurement [βiwv(baPWV) = -.0005, p = .8 and βiwv(cfPWV) = -.006, p = .16]. The above findings were consistent across sensitivity analyses including weighted median, mode-based estimation, MR-Egger regression and MR-PRESSO | ||
| 520 | |a CONCLUSION: We did not find evidence indicating that Lp(a) is causally associated with PWV, the gold standard marker of arterial stiffness | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Lp(a) | |
| 650 | 4 | |a Mendelian randomization | |
| 650 | 4 | |a PWV | |
| 650 | 4 | |a arterial stiffness | |
| 650 | 4 | |a causal association | |
| 650 | 4 | |a general population | |
| 650 | 7 | |a Lipoprotein(a) |2 NLM | |
| 700 | 1 | |a Georgiopoulos, Georgios |e verfasserin |4 aut | |
| 700 | 1 | |a Delialis, Dimitrios |e verfasserin |4 aut | |
| 700 | 1 | |a Mavraganis, Georgios |e verfasserin |4 aut | |
| 700 | 1 | |a Oikonomou, Ermioni |e verfasserin |4 aut | |
| 700 | 1 | |a Maneta, Eleni |e verfasserin |4 aut | |
| 700 | 1 | |a Loutos, Christos |e verfasserin |4 aut | |
| 700 | 1 | |a Evangelou, Evangelos |e verfasserin |4 aut | |
| 700 | 1 | |a Stamatelopoulos, Kimon |e verfasserin |4 aut | |
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