Alterations in hippocampus-centered morphological features and function of the progression from normal cognition to mild cognitive impairment
Copyright © 2024 Elsevier B.V. All rights reserved..
Mild cognitive impairment (MCI) is a significant precursor to dementia, highlighting the critical need for early identification of individuals at high risk of MCI to prevent cognitive decline. The study aimed to investigate the changes in brain structure and function before the onset of MCI. This study enrolled 19 older adults with progressive normal cognition (pNC) to MCI and 19 older adults with stable normal cognition (sNC). The gray matter (GM) volume and functional connectivity (FC) were estimated via magnetic resonance imaging during their normal cognition state 3 years prior. Additionally, spatial associations between FC maps and neurochemical profiles were examined using JuSpace. Compared to the sNC group, the pNC group showed decreased volume in the left hippocampus and left amygdala. The significantly positive correlation was observed between the GM volume of the left hippocampus and the MMSE scores after 3 years in pNC group. Besides, it showed that the pNC group had increased FC between the left hippocampus and the anterior-posterior cingulate gyrus, which was significantly correlated with the spatial distribution of dopamine D2 and noradrenaline transporter. Taken together, the study identified the abnormal brain characteristics before the onset of MCI, which might provide insight into clinical research.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:93 |
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| Enthalten in: |
Asian journal of psychiatry - 93(2024) vom: 05. März, Seite 103921 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Wang, Xiuxiu [VerfasserIn] |
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| Links: |
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| Themen: |
Functional connectivity |
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| Anmerkungen: |
Date Completed 08.03.2024 Date Revised 08.03.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.ajp.2024.103921 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM367280264 |
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| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2024 Elsevier B.V. All rights reserved. | ||
| 520 | |a Mild cognitive impairment (MCI) is a significant precursor to dementia, highlighting the critical need for early identification of individuals at high risk of MCI to prevent cognitive decline. The study aimed to investigate the changes in brain structure and function before the onset of MCI. This study enrolled 19 older adults with progressive normal cognition (pNC) to MCI and 19 older adults with stable normal cognition (sNC). The gray matter (GM) volume and functional connectivity (FC) were estimated via magnetic resonance imaging during their normal cognition state 3 years prior. Additionally, spatial associations between FC maps and neurochemical profiles were examined using JuSpace. Compared to the sNC group, the pNC group showed decreased volume in the left hippocampus and left amygdala. The significantly positive correlation was observed between the GM volume of the left hippocampus and the MMSE scores after 3 years in pNC group. Besides, it showed that the pNC group had increased FC between the left hippocampus and the anterior-posterior cingulate gyrus, which was significantly correlated with the spatial distribution of dopamine D2 and noradrenaline transporter. Taken together, the study identified the abnormal brain characteristics before the onset of MCI, which might provide insight into clinical research | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Functional connectivity | |
| 650 | 4 | |a Hippocampus | |
| 650 | 4 | |a Magnetic resonance imaging | |
| 650 | 4 | |a Mild cognitive impairment | |
| 650 | 4 | |a Neurotransmitters | |
| 700 | 1 | |a Peng, Lixin |e verfasserin |4 aut | |
| 700 | 1 | |a Zhan, Shiqi |e verfasserin |4 aut | |
| 700 | 1 | |a Yin, Xiaolong |e verfasserin |4 aut | |
| 700 | 1 | |a Huang, Li |e verfasserin |4 aut | |
| 700 | 1 | |a Huang, Jiayang |e verfasserin |4 aut | |
| 700 | 1 | |a Yang, Junchao |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Yusi |e verfasserin |4 aut | |
| 700 | 1 | |a Zeng, Yi |e verfasserin |4 aut | |
| 700 | 1 | |a Liang, Shengxiang |e verfasserin |4 aut | |
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