Cost-utility analysis of Dexcom G6 real-time continuous glucose monitoring versus FreeStyle Libre 1 intermittently scanned continuous glucose monitoring in adults with type 1 diabetes in Belgium
© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature..
AIMS/HYPOTHESIS: The aim of this study was to assess the long-term cost-effectiveness of Dexcom G6 real-time continuous glucose monitoring (rtCGM) with alert functionality compared with FreeStyle Libre 1 intermittently scanned continuous glucose monitoring (isCGM) without alerts in adults with type 1 diabetes in Belgium.
METHODS: The IQVIA CORE Diabetes Model was used to estimate cost-effectiveness. Input data for the simulated baseline cohort were sourced from the randomised ALERTT1 trial (ClinicalTrials.gov.
REGISTRATION NO: NCT03772600). The age of the participants was 42.9 ± 14.1 years (mean ± SD), and the baseline HbA1c was 57.8 ± 9.5 mmol/mol (7.4 ± 0.9%). Participants using rtCGM showed a reduction in HbA1c of 3.6 mmol/mol (0.36 percentage points) based on the 6-month mean between-group difference. In the base case, both rtCGM and isCGM were priced at €3.92/day (excluding value-added tax [VAT]) according to the Belgian reimbursement system. The analysis was performed from a Belgian healthcare payer perspective over a lifetime time horizon. Health outcomes were expressed as quality-adjusted life years. Probabilistic and one-way sensitivity analyses were used to account for parameter uncertainty.
RESULTS: In the base case, rtCGM dominated isCGM, resulting in lower diabetes-related complication costs and better health outcomes. The associated main drivers favouring rtCGM were lower HbA1c, fewer severe hypoglycaemic events and reduced fear of hypoglycaemia. The results were robust under a wide range of one-way sensitivity analyses. In models where the price of rtCGM is €5.11/day (a price increase of 30.4%) or €12.34/day (a price increase of 214.8%), rtCGM was cost-neutral or reached an incremental cost-effectiveness ratio of €40,000 per quality-adjusted life year, respectively.
CONCLUSIONS/INTERPRETATION: When priced similarly, Dexcom G6 rtCGM with alert functionality has both economic and clinical benefits compared with FreeStyle Libre 1 isCGM without alerts in adults with type 1 diabetes in Belgium, and appears to be a cost-effective glucose monitoring modality. Trial registration ClinicalTrials.gov NCT03772600.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2024 |
---|---|
Erschienen: |
2024 |
Enthalten in: |
Zur Gesamtaufnahme - volume:67 |
---|---|
Enthalten in: |
Diabetologia - 67(2024), 4 vom: 27. März, Seite 650-662 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Visser, Margaretha M [VerfasserIn] |
---|
Links: |
---|
Anmerkungen: |
Date Completed 01.03.2024 Date Revised 01.03.2024 published: Print-Electronic ClinicalTrials.gov: NCT03772600 Citation Status MEDLINE |
---|
doi: |
10.1007/s00125-023-06084-2 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM367269201 |
---|
LEADER | 01000caa a22002652 4500 | ||
---|---|---|---|
001 | NLM367269201 | ||
003 | DE-627 | ||
005 | 20240301232340.0 | ||
007 | cr uuu---uuuuu | ||
008 | 240118s2024 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1007/s00125-023-06084-2 |2 doi | |
028 | 5 | 2 | |a pubmed24n1313.xml |
035 | |a (DE-627)NLM367269201 | ||
035 | |a (NLM)38236409 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Visser, Margaretha M |e verfasserin |4 aut | |
245 | 1 | 0 | |a Cost-utility analysis of Dexcom G6 real-time continuous glucose monitoring versus FreeStyle Libre 1 intermittently scanned continuous glucose monitoring in adults with type 1 diabetes in Belgium |
264 | 1 | |c 2024 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Completed 01.03.2024 | ||
500 | |a Date Revised 01.03.2024 | ||
500 | |a published: Print-Electronic | ||
500 | |a ClinicalTrials.gov: NCT03772600 | ||
500 | |a Citation Status MEDLINE | ||
520 | |a © 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. | ||
520 | |a AIMS/HYPOTHESIS: The aim of this study was to assess the long-term cost-effectiveness of Dexcom G6 real-time continuous glucose monitoring (rtCGM) with alert functionality compared with FreeStyle Libre 1 intermittently scanned continuous glucose monitoring (isCGM) without alerts in adults with type 1 diabetes in Belgium | ||
520 | |a METHODS: The IQVIA CORE Diabetes Model was used to estimate cost-effectiveness. Input data for the simulated baseline cohort were sourced from the randomised ALERTT1 trial (ClinicalTrials.gov | ||
520 | |a REGISTRATION NO: NCT03772600). The age of the participants was 42.9 ± 14.1 years (mean ± SD), and the baseline HbA1c was 57.8 ± 9.5 mmol/mol (7.4 ± 0.9%). Participants using rtCGM showed a reduction in HbA1c of 3.6 mmol/mol (0.36 percentage points) based on the 6-month mean between-group difference. In the base case, both rtCGM and isCGM were priced at €3.92/day (excluding value-added tax [VAT]) according to the Belgian reimbursement system. The analysis was performed from a Belgian healthcare payer perspective over a lifetime time horizon. Health outcomes were expressed as quality-adjusted life years. Probabilistic and one-way sensitivity analyses were used to account for parameter uncertainty | ||
520 | |a RESULTS: In the base case, rtCGM dominated isCGM, resulting in lower diabetes-related complication costs and better health outcomes. The associated main drivers favouring rtCGM were lower HbA1c, fewer severe hypoglycaemic events and reduced fear of hypoglycaemia. The results were robust under a wide range of one-way sensitivity analyses. In models where the price of rtCGM is €5.11/day (a price increase of 30.4%) or €12.34/day (a price increase of 214.8%), rtCGM was cost-neutral or reached an incremental cost-effectiveness ratio of €40,000 per quality-adjusted life year, respectively | ||
520 | |a CONCLUSIONS/INTERPRETATION: When priced similarly, Dexcom G6 rtCGM with alert functionality has both economic and clinical benefits compared with FreeStyle Libre 1 isCGM without alerts in adults with type 1 diabetes in Belgium, and appears to be a cost-effective glucose monitoring modality. Trial registration ClinicalTrials.gov NCT03772600 | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Cost-effectiveness | |
650 | 4 | |a Cost–utility analysis | |
650 | 4 | |a Economic evaluation | |
650 | 4 | |a Intermittently scanned continuous glucose monitoring | |
650 | 4 | |a Real-time continuous glucose monitoring | |
650 | 4 | |a Type 1 diabetes | |
650 | 7 | |a Blood Glucose |2 NLM | |
650 | 7 | |a Hypoglycemic Agents |2 NLM | |
700 | 1 | |a Van Muylder, Astrid |e verfasserin |4 aut | |
700 | 1 | |a Charleer, Sara |e verfasserin |4 aut | |
700 | 1 | |a Isitt, John J |e verfasserin |4 aut | |
700 | 1 | |a Roze, Stéphane |e verfasserin |4 aut | |
700 | 1 | |a De Block, Christophe |e verfasserin |4 aut | |
700 | 1 | |a Maes, Toon |e verfasserin |4 aut | |
700 | 1 | |a Vanhaverbeke, Gerd |e verfasserin |4 aut | |
700 | 1 | |a Nobels, Frank |e verfasserin |4 aut | |
700 | 1 | |a Keymeulen, Bart |e verfasserin |4 aut | |
700 | 1 | |a Mathieu, Chantal |e verfasserin |4 aut | |
700 | 1 | |a Luyten, Jeroen |e verfasserin |4 aut | |
700 | 1 | |a Gillard, Pieter |e verfasserin |4 aut | |
700 | 1 | |a Verhaeghe, Nick |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Diabetologia |d 1966 |g 67(2024), 4 vom: 27. März, Seite 650-662 |w (DE-627)NLM000017035 |x 1432-0428 |7 nnns |
773 | 1 | 8 | |g volume:67 |g year:2024 |g number:4 |g day:27 |g month:03 |g pages:650-662 |
856 | 4 | 0 | |u http://dx.doi.org/10.1007/s00125-023-06084-2 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 67 |j 2024 |e 4 |b 27 |c 03 |h 650-662 |