Differences in clinical characteristics of early-onset and late-onset severe acute respiratory syndrome coronavirus 2 infections in neonates
© 2024. The Author(s)..
Differences in clinical characteristics of early-onset and late-onset severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections in neonates remain unclear. This study aimed to determine whether there are differences in the main clinical, radiological, and laboratory features of early-onset and late-onset SARS-CoV-2 infections in neonates. This single-center, prospective cohort study enrolled neonates with SARS-CoV-2 infection from December 7, 2022, to January 3, 2023, and evaluated their clinical characteristics during hospitalization. All neonates (N = 58) infected with SARS-CoV-2 within 28 days of birth who were admitted to the neonatal intensive care unit of Taizhou Hospital were included. These neonates were classified into the early-onset (diagnosed within 7 days of birth) and late-onset (diagnosed more than 7 days after birth) groups. The symptoms, treatment, and prognosis of SARS-CoV-2 infection were the main study outcomes. The incidence of hospitalization attributable to SARS-CoV-2 infection was 10.6% (58 of 546 neonates) in Linhai. Sixteen (28%) of the 58 SARS-CoV-2 infections were early-onset cases, and 42 (72%) were late-onset cases. The common symptoms among the late-onset group were fever (p < 0.001) and cough (p < 0.001). Neonates with late-onset SARS-CoV-2 infection (p < 0.001) were significantly more likely to develop pneumonia. Conclusion: The clinical symptoms and rates of pneumonia caused by SARS-CoV-2 infection in neonates differed between the early-onset and late-onset groups. Different clinical management is necessary for neonates with early-onset and late-onset SARS-CoV-2 infections. What is Known: • Neonates are susceptible to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). • Differences in clinical characteristics of early-onset and late-onset SARS-CoV-2 infections in neonates remain unclear. What is New: • Fever and cough were the most common symptoms among neonates with late-onset infection. • Neonates with late-onset SARS-CoV-2 infection were more likely to develop pneumonia.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2024 |
---|---|
Erschienen: |
2024 |
Enthalten in: |
Zur Gesamtaufnahme - volume:183 |
---|---|
Enthalten in: |
European journal of pediatrics - 183(2024), 4 vom: 15. Apr., Seite 1741-1750 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Wu, Yi-Xin [VerfasserIn] |
---|
Links: |
---|
Themen: |
COVID-19 |
---|
Anmerkungen: |
Date Completed 09.04.2024 Date Revised 11.04.2024 published: Print-Electronic Citation Status MEDLINE |
---|
doi: |
10.1007/s00431-024-05433-6 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM367241196 |
---|
LEADER | 01000caa a22002652 4500 | ||
---|---|---|---|
001 | NLM367241196 | ||
003 | DE-627 | ||
005 | 20240411232241.0 | ||
007 | cr uuu---uuuuu | ||
008 | 240118s2024 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1007/s00431-024-05433-6 |2 doi | |
028 | 5 | 2 | |a pubmed24n1372.xml |
035 | |a (DE-627)NLM367241196 | ||
035 | |a (NLM)38233605 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Wu, Yi-Xin |e verfasserin |4 aut | |
245 | 1 | 0 | |a Differences in clinical characteristics of early-onset and late-onset severe acute respiratory syndrome coronavirus 2 infections in neonates |
264 | 1 | |c 2024 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Completed 09.04.2024 | ||
500 | |a Date Revised 11.04.2024 | ||
500 | |a published: Print-Electronic | ||
500 | |a Citation Status MEDLINE | ||
520 | |a © 2024. The Author(s). | ||
520 | |a Differences in clinical characteristics of early-onset and late-onset severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections in neonates remain unclear. This study aimed to determine whether there are differences in the main clinical, radiological, and laboratory features of early-onset and late-onset SARS-CoV-2 infections in neonates. This single-center, prospective cohort study enrolled neonates with SARS-CoV-2 infection from December 7, 2022, to January 3, 2023, and evaluated their clinical characteristics during hospitalization. All neonates (N = 58) infected with SARS-CoV-2 within 28 days of birth who were admitted to the neonatal intensive care unit of Taizhou Hospital were included. These neonates were classified into the early-onset (diagnosed within 7 days of birth) and late-onset (diagnosed more than 7 days after birth) groups. The symptoms, treatment, and prognosis of SARS-CoV-2 infection were the main study outcomes. The incidence of hospitalization attributable to SARS-CoV-2 infection was 10.6% (58 of 546 neonates) in Linhai. Sixteen (28%) of the 58 SARS-CoV-2 infections were early-onset cases, and 42 (72%) were late-onset cases. The common symptoms among the late-onset group were fever (p < 0.001) and cough (p < 0.001). Neonates with late-onset SARS-CoV-2 infection (p < 0.001) were significantly more likely to develop pneumonia. Conclusion: The clinical symptoms and rates of pneumonia caused by SARS-CoV-2 infection in neonates differed between the early-onset and late-onset groups. Different clinical management is necessary for neonates with early-onset and late-onset SARS-CoV-2 infections. What is Known: • Neonates are susceptible to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). • Differences in clinical characteristics of early-onset and late-onset SARS-CoV-2 infections in neonates remain unclear. What is New: • Fever and cough were the most common symptoms among neonates with late-onset infection. • Neonates with late-onset SARS-CoV-2 infection were more likely to develop pneumonia | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a COVID-19 | |
650 | 4 | |a Neonatal intensive care unit | |
650 | 4 | |a Neonate | |
650 | 4 | |a Pneumonia | |
650 | 4 | |a SARS-CoV-2 | |
700 | 1 | |a Wang, Dan-Dan |e verfasserin |4 aut | |
700 | 1 | |a Zhao, Ru-Qi |e verfasserin |4 aut | |
700 | 1 | |a Jin, Ou-Xuan |e verfasserin |4 aut | |
700 | 1 | |a Yang, Jing-Yun |e verfasserin |4 aut | |
700 | 1 | |a Zhang, Mei-Xian |e verfasserin |4 aut | |
700 | 1 | |a Wang, Li-Zhen |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t European journal of pediatrics |d 1978 |g 183(2024), 4 vom: 15. Apr., Seite 1741-1750 |w (DE-627)NLM000029718 |x 1432-1076 |7 nnns |
773 | 1 | 8 | |g volume:183 |g year:2024 |g number:4 |g day:15 |g month:04 |g pages:1741-1750 |
856 | 4 | 0 | |u http://dx.doi.org/10.1007/s00431-024-05433-6 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 183 |j 2024 |e 4 |b 15 |c 04 |h 1741-1750 |