A multi-parameter intrahepatic cholangiocarcinoma scoring system based on modified contrast-enhanced ultrasound LI-RADS M criteria for differentiating intrahepatic cholangiocarcinoma from hepatocellular carcinoma
© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature..
PURPOSE: To develop a multi-parameter intrahepatic cholangiocarcinoma (ICC) scoring system and compare its diagnostic performance with contrast-enhanced ultrasound (CEUS) liver imaging reporting and data system M (LR-M) criteria for differentiating ICC from hepatocellular carcinoma (HCC).
METHODS: This retrospective study enrolled 62 high-risk patients with ICCs and 62 high-risk patients with matched HCCs between January 2022 and December 2022 from two institutions. The CEUS LR-M criteria was modified by adjusting the early wash-out onset (within 45 s) and the marked wash-out (within 3 min). Then, a multi-parameter ICC scoring system was established based on clinical features, B-mode ultrasound features, and modified LR-M criteria.
RESULT: We found that elevated CA 19-9 (OR=12.647), lesion boundary (OR=11.601), peripheral rim-like arterial phase hyperenhancement (OR=23.654), early wash-out onset (OR=7.211), and marked wash-out (OR=19.605) were positive predictors of ICC, whereas elevated alpha-fetoprotein (OR=0.078) was a negative predictor. Based on these findings, an ICC scoring system was established. Compared with the modified LR-M and LR-M criteria, the ICC scoring system showed the highest area under the curve (0.911 vs. 0.831 and 0.750, both p<0.05) and specificity (0.935 vs. 0.774 and 0.565, both p<0.05). Moreover, the numbers of HCCs categorized as LR-M decreased from 27 (43.5%) to 14 (22.6%) and 4 (6.5%) using the modified LR-M criteria and ICC scoring system, respectively.
CONCLUSION: The modified LR-M criteria-based multi-parameter ICC scoring system had the highest specificity for diagnosing ICC and reduced the number of HCC cases diagnosed as LR-M category.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:49 |
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| Enthalten in: |
Abdominal radiology (New York) - 49(2024), 2 vom: 15. Feb., Seite 458-470 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Wang, Li-Fan [VerfasserIn] |
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| Links: |
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| Themen: |
Contrast Media |
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| Anmerkungen: |
Date Completed 01.02.2024 Date Revised 01.02.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1007/s00261-023-04114-6 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM367159325 |
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| 100 | 1 | |a Wang, Li-Fan |e verfasserin |4 aut | |
| 245 | 1 | 2 | |a A multi-parameter intrahepatic cholangiocarcinoma scoring system based on modified contrast-enhanced ultrasound LI-RADS M criteria for differentiating intrahepatic cholangiocarcinoma from hepatocellular carcinoma |
| 264 | 1 | |c 2024 | |
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| 500 | |a Date Completed 01.02.2024 | ||
| 500 | |a Date Revised 01.02.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. | ||
| 520 | |a PURPOSE: To develop a multi-parameter intrahepatic cholangiocarcinoma (ICC) scoring system and compare its diagnostic performance with contrast-enhanced ultrasound (CEUS) liver imaging reporting and data system M (LR-M) criteria for differentiating ICC from hepatocellular carcinoma (HCC) | ||
| 520 | |a METHODS: This retrospective study enrolled 62 high-risk patients with ICCs and 62 high-risk patients with matched HCCs between January 2022 and December 2022 from two institutions. The CEUS LR-M criteria was modified by adjusting the early wash-out onset (within 45 s) and the marked wash-out (within 3 min). Then, a multi-parameter ICC scoring system was established based on clinical features, B-mode ultrasound features, and modified LR-M criteria | ||
| 520 | |a RESULT: We found that elevated CA 19-9 (OR=12.647), lesion boundary (OR=11.601), peripheral rim-like arterial phase hyperenhancement (OR=23.654), early wash-out onset (OR=7.211), and marked wash-out (OR=19.605) were positive predictors of ICC, whereas elevated alpha-fetoprotein (OR=0.078) was a negative predictor. Based on these findings, an ICC scoring system was established. Compared with the modified LR-M and LR-M criteria, the ICC scoring system showed the highest area under the curve (0.911 vs. 0.831 and 0.750, both p<0.05) and specificity (0.935 vs. 0.774 and 0.565, both p<0.05). Moreover, the numbers of HCCs categorized as LR-M decreased from 27 (43.5%) to 14 (22.6%) and 4 (6.5%) using the modified LR-M criteria and ICC scoring system, respectively | ||
| 520 | |a CONCLUSION: The modified LR-M criteria-based multi-parameter ICC scoring system had the highest specificity for diagnosing ICC and reduced the number of HCC cases diagnosed as LR-M category | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Contrast-enhanced ultrasound | |
| 650 | 4 | |a Hepatocellular carcinoma | |
| 650 | 4 | |a Intrahepatic cholangiocarcinoma | |
| 650 | 4 | |a Liver imaging reporting and data system | |
| 650 | 7 | |a Contrast Media |2 NLM | |
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| 700 | 1 | |a Shen, Yu-Ting |e verfasserin |4 aut | |
| 700 | 1 | |a Zhou, Bo-Yang |e verfasserin |4 aut | |
| 700 | 1 | |a Sun, Yi-Kang |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Xiao-Long |e verfasserin |4 aut | |
| 700 | 1 | |a Yin, Hao-Hao |e verfasserin |4 aut | |
| 700 | 1 | |a Lu, Dan |e verfasserin |4 aut | |
| 700 | 1 | |a Ye, Xin |e verfasserin |4 aut | |
| 700 | 1 | |a Hu, Xin-Yuan |e verfasserin |4 aut | |
| 700 | 1 | |a Yang, Dao-Hui |e verfasserin |4 aut | |
| 700 | 1 | |a Xia, Han-Sheng |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Xi |e verfasserin |4 aut | |
| 700 | 1 | |a Lu, Qing |e verfasserin |4 aut | |
| 700 | 1 | |a Han, Hong |e verfasserin |4 aut | |
| 700 | 1 | |a Xu, Hui-Xiong |e verfasserin |4 aut | |
| 700 | 1 | |a Zhao, Chong-Ke |e verfasserin |4 aut | |
| 700 | 0 | |a China Alliance of Multi-Center Clinical Study for Ultrasound (Ultra-Chance) |e verfasserin |4 aut | |
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