Neural correlates of drinking reduction during a clinical trial of cognitive behavioral therapy for alcohol use disorder
© 2024 Research Society on Alcohol..
BACKGROUND: Cognitive behavioral therapy (CBT) is an effective treatment for alcohol use disorder (AUD). We hypothesized that the dorsolateral prefrontal cortex (DLPFC), a region implicated in cognitive control and goal-directed behavior, plays a role in behavior change during CBT by facilitating the regulation of craving (ROC).
METHODS: Treatment-seeking participants with AUD (N = 22) underwent functional magnetic resonance imaging (fMRI) scanning both before and after a 12-week, single-arm trial of CBT, using an ROC task that was previously shown to engage the DLPFC.
RESULTS: We found that both the percentage of heavy drinking days (PHDD) and the overall self-reported alcohol craving measured during the ROC task were significantly reduced from pre- to post-CBT. However, we did not find significant changes over time in either the ability to regulate craving or regulation-related activity in any brain region. We found a significant 3-way interaction between the effects of cue-induced craving, cue-induced brain activity and timepoint of assessment (pre- or post-CBT) on PHDD in the left DLPFC. Follow-up analysis showed that cue-induced craving was associated with cue-induced activity in the left DLPFC among participants who ceased heavy drinking during CBT, both at pre-CBT and post-CBT timepoints. No such associations were present at either timepoint among participants who continued to drink heavily.
CONCLUSIONS: These results suggest that patients in whom DLPFC functioning is more strongly related to cue-induced craving may preferentially respond to CBT.
| Errataetall: | |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:48 |
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| Enthalten in: |
Alcohol, clinical & experimental research - 48(2024), 2 vom: 12. Feb., Seite 260-272 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Naqvi, Nasir H [VerfasserIn] |
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| Links: |
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| Themen: |
Alcohol use disorder |
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| Anmerkungen: |
Date Revised 25.04.2024 published: Print-Electronic UpdateOf: bioRxiv. 2023 Feb 10;:. - PMID 36798260 Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1111/acer.15259 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM367157373 |
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| 500 | |a UpdateOf: bioRxiv. 2023 Feb 10;:. - PMID 36798260 | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a © 2024 Research Society on Alcohol. | ||
| 520 | |a BACKGROUND: Cognitive behavioral therapy (CBT) is an effective treatment for alcohol use disorder (AUD). We hypothesized that the dorsolateral prefrontal cortex (DLPFC), a region implicated in cognitive control and goal-directed behavior, plays a role in behavior change during CBT by facilitating the regulation of craving (ROC) | ||
| 520 | |a METHODS: Treatment-seeking participants with AUD (N = 22) underwent functional magnetic resonance imaging (fMRI) scanning both before and after a 12-week, single-arm trial of CBT, using an ROC task that was previously shown to engage the DLPFC | ||
| 520 | |a RESULTS: We found that both the percentage of heavy drinking days (PHDD) and the overall self-reported alcohol craving measured during the ROC task were significantly reduced from pre- to post-CBT. However, we did not find significant changes over time in either the ability to regulate craving or regulation-related activity in any brain region. We found a significant 3-way interaction between the effects of cue-induced craving, cue-induced brain activity and timepoint of assessment (pre- or post-CBT) on PHDD in the left DLPFC. Follow-up analysis showed that cue-induced craving was associated with cue-induced activity in the left DLPFC among participants who ceased heavy drinking during CBT, both at pre-CBT and post-CBT timepoints. No such associations were present at either timepoint among participants who continued to drink heavily | ||
| 520 | |a CONCLUSIONS: These results suggest that patients in whom DLPFC functioning is more strongly related to cue-induced craving may preferentially respond to CBT | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a alcohol use disorder | |
| 650 | 4 | |a cognitive control | |
| 650 | 4 | |a craving | |
| 650 | 4 | |a dorsolateral prefrontal cortex | |
| 650 | 4 | |a regulation of craving | |
| 700 | 1 | |a Srivastava, A Benjamin |e verfasserin |4 aut | |
| 700 | 1 | |a Sanchez-Peña, Juan |e verfasserin |4 aut | |
| 700 | 1 | |a Lee, Jessica K |e verfasserin |4 aut | |
| 700 | 1 | |a Drysdale, Andrew T |e verfasserin |4 aut | |
| 700 | 1 | |a Mariani, John J |e verfasserin |4 aut | |
| 700 | 1 | |a Ochsner, Kevin N |e verfasserin |4 aut | |
| 700 | 1 | |a Morgenstern, Jon |e verfasserin |4 aut | |
| 700 | 1 | |a Patel, Gaurav H |e verfasserin |4 aut | |
| 700 | 1 | |a Levin, Frances R |e verfasserin |4 aut | |
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