Novel anionic surfactant-modified chlorhexidine and its potent antimicrobial properties
Chlorhexidine dodecyl sulfate (CHX-DS) was synthesized and characterized via single-crystal X-ray diffraction (SC-XRD), 1H nuclear magnetic resonance (NMR) spectroscopy, 1H nuclear Overhauser effect spectroscopy (NOESY), and attenuated total reflectance Fourier-transform infrared spectroscopy (ATR-FTIR). The solid-state structure, comprising a 1 : 2 stoichiometric ratio of chlorhexidine cations [C22H30Cl2N10]2+ to dodecyl sulfate anions [C12H25SO4]-, is the first report of chlorhexidine isolated with a surfactant. CHX-DS exhibits broad-spectrum antibacterial activity and demonstrates superior efficacy for reducing bacteria-generated volatile sulfur compounds (VSCs) as compared to chlorhexidine gluconate (CHG). The minimum inhibitory concentrations (MICs) of CHX-DS were 7.5, 2.5, 2.5, and 10 μM for S. enterica, E. coli, S. aureus, and S. mutans, respectively. Furthermore, MIC assays for E. coli and S. mutans demonstrate that CHX-DS and CHX exhibit a statistically significant efficacy enhancement in 2.5 μM treatment as compared to CHG. CHX-DS was incorporated into SBA-15, a mesoporous silica nanoparticle (MSN) framework, and its release was qualitatively measured via UV-vis in aqueous media, which suggests its potential as an advanced functional material for drug delivery applications.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:53 |
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| Enthalten in: |
Dalton transactions (Cambridge, England : 2003) - 53(2024), 6 vom: 06. Feb., Seite 2670-2677 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Muneeswaran, Zilma Pereira [VerfasserIn] |
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| Links: |
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| Themen: |
368GB5141J |
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| Anmerkungen: |
Date Completed 07.02.2024 Date Revised 07.02.2024 published: Electronic Citation Status MEDLINE |
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| doi: |
10.1039/d3dt02559d |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM367148390 |
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| 520 | |a Chlorhexidine dodecyl sulfate (CHX-DS) was synthesized and characterized via single-crystal X-ray diffraction (SC-XRD), 1H nuclear magnetic resonance (NMR) spectroscopy, 1H nuclear Overhauser effect spectroscopy (NOESY), and attenuated total reflectance Fourier-transform infrared spectroscopy (ATR-FTIR). The solid-state structure, comprising a 1 : 2 stoichiometric ratio of chlorhexidine cations [C22H30Cl2N10]2+ to dodecyl sulfate anions [C12H25SO4]-, is the first report of chlorhexidine isolated with a surfactant. CHX-DS exhibits broad-spectrum antibacterial activity and demonstrates superior efficacy for reducing bacteria-generated volatile sulfur compounds (VSCs) as compared to chlorhexidine gluconate (CHG). The minimum inhibitory concentrations (MICs) of CHX-DS were 7.5, 2.5, 2.5, and 10 μM for S. enterica, E. coli, S. aureus, and S. mutans, respectively. Furthermore, MIC assays for E. coli and S. mutans demonstrate that CHX-DS and CHX exhibit a statistically significant efficacy enhancement in 2.5 μM treatment as compared to CHG. CHX-DS was incorporated into SBA-15, a mesoporous silica nanoparticle (MSN) framework, and its release was qualitatively measured via UV-vis in aqueous media, which suggests its potential as an advanced functional material for drug delivery applications | ||
| 650 | 4 | |a Journal Article | |
| 650 | 7 | |a chlorhexidine gluconate |2 NLM | |
| 650 | 7 | |a MOR84MUD8E |2 NLM | |
| 650 | 7 | |a Chlorhexidine |2 NLM | |
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| 700 | 1 | |a Wang, Yu |e verfasserin |4 aut | |
| 700 | 1 | |a Chaudhry, Haroon |e verfasserin |4 aut | |
| 700 | 1 | |a Brinzari, Tatiana V |e verfasserin |4 aut | |
| 700 | 1 | |a Verma, Gaurav |e verfasserin |4 aut | |
| 700 | 1 | |a Ranasinghe, Lomaani |e verfasserin |4 aut | |
| 700 | 1 | |a Kaler, Kylie Ryan |e verfasserin |4 aut | |
| 700 | 1 | |a Huang, Xiaoyi |e verfasserin |4 aut | |
| 700 | 1 | |a He, Xing |e verfasserin |4 aut | |
| 700 | 1 | |a Thomas, Belvin |e verfasserin |4 aut | |
| 700 | 1 | |a Xu, Shiyou |e verfasserin |4 aut | |
| 700 | 1 | |a Cheng, Chi-Yuan |e verfasserin |4 aut | |
| 700 | 1 | |a Boyd, Jeffrey M |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Dailin |e verfasserin |4 aut | |
| 700 | 1 | |a Hao, Zhigang |e verfasserin |4 aut | |
| 700 | 1 | |a Ma, Shengqian |e verfasserin |4 aut | |
| 700 | 1 | |a Asefa, Tewodros |e verfasserin |4 aut | |
| 700 | 1 | |a Pan, Long |e verfasserin |4 aut | |
| 700 | 1 | |a Dubovoy, Viktor |e verfasserin |4 aut | |
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