Impact of subgingival instrumentation on systemic inflammation and serum bone resorption marker in premenopausal women with periodontitis : a prospective interventional study
OBJECTIVES: Inflammatory disorders including periodontitis have been investigated for their impact on systemic inflammation and bone health. The present study was conducted with an aim to evaluate impact of control of periodontal inflammation through subgingival instrumentation on serum interleukin 6 and serum C-terminal telopeptide of type I collagen (CTX) in premenopausal females with stage II and III periodontitis.
METHOD AND MATERIALS: In this single-arm prospective study, periodontal parameters, serum interleukin 6, serum CTX, and hematologic parameters (total leukocyte count, differential leukocyte count, platelet count, mean platelet volume, and platelet distribution width) were assessed at baseline. Subgingival instrumentation was done, and oral hygiene instructions were given. At week 4, professional plaque control was performed, and oral hygiene instructions were reinforced. Serum and hematologic parameters were reassessed at 8 weeks after subgingival instrumentation, in individuals meeting the clinical endpoints (ie, bleeding on probing < 10%).
RESULTS: There was significant reduction in serum interleukin 6 of 0.168 ± 0.164 pg/mL (P = .000), and serum CTX of 17.459 ± 4.363 pg/mL (P = .000) at 8 weeks after subgingival instrumentation. There was significant decrease in eosinophil count (P = .018) and mean platelet volume (P = .016) at 8 weeks after subgingival instrumentation; however, no significant change was found in other hematologic parameters.
CONCLUSION: Following subgingival instrumentation, biomarkers of both systemic inflammation (interleukin 6) and bone turnover (CTX) were observed to reduce significantly. This finding hints towards a positive impact of periodontal intervention on bone health.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2024 |
|---|---|
| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:55 |
|---|---|
| Enthalten in: |
Quintessence international (Berlin, Germany : 1985) - 55(2024), 2 vom: 28. Feb., Seite 108-118 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Sharma, Pradeep [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Bone resorption |
|---|
| Anmerkungen: |
Date Completed 29.02.2024 Date Revised 29.02.2024 published: Print Citation Status MEDLINE |
|---|
| doi: |
10.3290/j.qi.b4867855 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM367146630 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM367146630 | ||
| 003 | DE-627 | ||
| 005 | 20240229234743.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240115s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.3290/j.qi.b4867855 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1311.xml |
| 035 | |a (DE-627)NLM367146630 | ||
| 035 | |a (NLM)38224106 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Sharma, Pradeep |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Impact of subgingival instrumentation on systemic inflammation and serum bone resorption marker in premenopausal women with periodontitis |b a prospective interventional study |
| 264 | 1 | |c 2024 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 29.02.2024 | ||
| 500 | |a Date Revised 29.02.2024 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a OBJECTIVES: Inflammatory disorders including periodontitis have been investigated for their impact on systemic inflammation and bone health. The present study was conducted with an aim to evaluate impact of control of periodontal inflammation through subgingival instrumentation on serum interleukin 6 and serum C-terminal telopeptide of type I collagen (CTX) in premenopausal females with stage II and III periodontitis | ||
| 520 | |a METHOD AND MATERIALS: In this single-arm prospective study, periodontal parameters, serum interleukin 6, serum CTX, and hematologic parameters (total leukocyte count, differential leukocyte count, platelet count, mean platelet volume, and platelet distribution width) were assessed at baseline. Subgingival instrumentation was done, and oral hygiene instructions were given. At week 4, professional plaque control was performed, and oral hygiene instructions were reinforced. Serum and hematologic parameters were reassessed at 8 weeks after subgingival instrumentation, in individuals meeting the clinical endpoints (ie, bleeding on probing < 10%) | ||
| 520 | |a RESULTS: There was significant reduction in serum interleukin 6 of 0.168 ± 0.164 pg/mL (P = .000), and serum CTX of 17.459 ± 4.363 pg/mL (P = .000) at 8 weeks after subgingival instrumentation. There was significant decrease in eosinophil count (P = .018) and mean platelet volume (P = .016) at 8 weeks after subgingival instrumentation; however, no significant change was found in other hematologic parameters | ||
| 520 | |a CONCLUSION: Following subgingival instrumentation, biomarkers of both systemic inflammation (interleukin 6) and bone turnover (CTX) were observed to reduce significantly. This finding hints towards a positive impact of periodontal intervention on bone health | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a bone resorption | |
| 650 | 4 | |a inflammation | |
| 650 | 4 | |a interleukin 6 | |
| 650 | 4 | |a nonsurgical periodontal therapy | |
| 650 | 4 | |a osteoporosis | |
| 650 | 4 | |a periodontitis | |
| 650 | 7 | |a Interleukin-6 |2 NLM | |
| 700 | 1 | |a Sharma, Rajinder Kumar |e verfasserin |4 aut | |
| 700 | 1 | |a Tewari, Shikha |e verfasserin |4 aut | |
| 700 | 1 | |a Gill, Paramjeet Singh |e verfasserin |4 aut | |
| 700 | 1 | |a Tanwar, Nishi |e verfasserin |4 aut | |
| 700 | 1 | |a Arora, Ritika |e verfasserin |4 aut | |
| 700 | 1 | |a Kaur, Manpreet |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Quintessence international (Berlin, Germany : 1985) |d 1985 |g 55(2024), 2 vom: 28. Feb., Seite 108-118 |w (DE-627)NLM012684309 |x 1936-7163 |7 nnns |
| 773 | 1 | 8 | |g volume:55 |g year:2024 |g number:2 |g day:28 |g month:02 |g pages:108-118 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.3290/j.qi.b4867855 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 55 |j 2024 |e 2 |b 28 |c 02 |h 108-118 | ||