Peri-operative score for elderly patients with resectable hepatocellular carcinoma
©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved..
BACKGROUND: Liver resection is the mainstay for a curative treatment for patients with resectable hepatocellular carcinoma (HCC), also in elderly population. Despite this, the evaluation of patient condition, liver function and extent of disease remains a demanding process with the aim to reduce postoperative morbidity and mortality.
AIM: To identify new perioperative risk factors that could be associated with higher 90- and 180-d mortality in elderly patients eligible for liver resection for HCC considering traditional perioperative risk scores and to develop a risk score.
METHODS: A multicentric, retrospective study was performed by reviewing the medical records of patients aged 70 years or older who electively underwent liver resection for HCC; several independent variables correlated with death from all causes at 90 and 180 d were studied. The coefficients of Cox regression proportional-hazards model for six-month mortality were rounded to the nearest integer to assign risk factors' weights and derive the scoring algorithm.
RESULTS: Multivariate analysis found variables (American Society of Anesthesiology score, high rate of comorbidities, Mayo end stage liver disease score and size of biggest lesion) that had independent correlations with increased 90- and 180-d mortality. A clinical risk score was developed with survival profiles.
CONCLUSION: This score can aid in stratifying this population in order to assess who can benefit from surgical treatment in terms of postoperative mortality.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:15 |
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| Enthalten in: |
World journal of hepatology - 15(2023), 12 vom: 27. Dez., Seite 1307-1314 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Conticchio, Maria [VerfasserIn] |
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| Links: |
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| Themen: |
Elderly patients |
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| Anmerkungen: |
Date Revised 16.01.2024 published: Print Citation Status PubMed-not-MEDLINE |
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| doi: |
10.4254/wjh.v15.i12.1307 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM367139693 |
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| 100 | 1 | |a Conticchio, Maria |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Peri-operative score for elderly patients with resectable hepatocellular carcinoma |
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| 500 | |a Date Revised 16.01.2024 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. | ||
| 520 | |a BACKGROUND: Liver resection is the mainstay for a curative treatment for patients with resectable hepatocellular carcinoma (HCC), also in elderly population. Despite this, the evaluation of patient condition, liver function and extent of disease remains a demanding process with the aim to reduce postoperative morbidity and mortality | ||
| 520 | |a AIM: To identify new perioperative risk factors that could be associated with higher 90- and 180-d mortality in elderly patients eligible for liver resection for HCC considering traditional perioperative risk scores and to develop a risk score | ||
| 520 | |a METHODS: A multicentric, retrospective study was performed by reviewing the medical records of patients aged 70 years or older who electively underwent liver resection for HCC; several independent variables correlated with death from all causes at 90 and 180 d were studied. The coefficients of Cox regression proportional-hazards model for six-month mortality were rounded to the nearest integer to assign risk factors' weights and derive the scoring algorithm | ||
| 520 | |a RESULTS: Multivariate analysis found variables (American Society of Anesthesiology score, high rate of comorbidities, Mayo end stage liver disease score and size of biggest lesion) that had independent correlations with increased 90- and 180-d mortality. A clinical risk score was developed with survival profiles | ||
| 520 | |a CONCLUSION: This score can aid in stratifying this population in order to assess who can benefit from surgical treatment in terms of postoperative mortality | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Elderly patients | |
| 650 | 4 | |a Hepatocellular carcinoma | |
| 650 | 4 | |a Laparoscopy | |
| 650 | 4 | |a Multivariate analysis | |
| 650 | 4 | |a Score | |
| 650 | 4 | |a Surgical resection | |
| 700 | 1 | |a Inchingolo, Riccardo |e verfasserin |4 aut | |
| 700 | 1 | |a Delvecchio, Antonella |e verfasserin |4 aut | |
| 700 | 1 | |a Ratti, Francesca |e verfasserin |4 aut | |
| 700 | 1 | |a Gelli, Maximiliano |e verfasserin |4 aut | |
| 700 | 1 | |a Anelli, Massimiliano Ferdinando |e verfasserin |4 aut | |
| 700 | 1 | |a Laurent, Alexis |e verfasserin |4 aut | |
| 700 | 1 | |a Vitali, Giulio Cesare |e verfasserin |4 aut | |
| 700 | 1 | |a Magistri, Paolo |e verfasserin |4 aut | |
| 700 | 1 | |a Assirati, Giacomo |e verfasserin |4 aut | |
| 700 | 1 | |a Felli, Emanuele |e verfasserin |4 aut | |
| 700 | 1 | |a Wakabayashi, Taiga |e verfasserin |4 aut | |
| 700 | 1 | |a Pessaux, Patrick |e verfasserin |4 aut | |
| 700 | 1 | |a Piardi, Tullio |e verfasserin |4 aut | |
| 700 | 1 | |a di Benedetto, Fabrizio |e verfasserin |4 aut | |
| 700 | 1 | |a de'Angelis, Nicola |e verfasserin |4 aut | |
| 700 | 1 | |a Briceño, Javier |e verfasserin |4 aut | |
| 700 | 1 | |a Rampoldi, Antonio |e verfasserin |4 aut | |
| 700 | 1 | |a Adam, Renè |e verfasserin |4 aut | |
| 700 | 1 | |a Cherqui, Daniel |e verfasserin |4 aut | |
| 700 | 1 | |a Aldrighetti, Luca Antonio |e verfasserin |4 aut | |
| 700 | 1 | |a Memeo, Riccardo |e verfasserin |4 aut | |
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