Molecular Mechanisms in the Etiology of Polycystic Ovary Syndrome (PCOS) : A Multifaceted Hypothesis Towards the Disease with Potential Therapeutics
© The Author(s), under exclusive licence to Association of Clinical Biochemists of India 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law..
Among the premenopausal women, Polycystic Ovary Syndrome (PCOS) is the most prevalent endocrinopathy affecting the reproductive system and metabolic rhythms leading to disrupted menstrual cycle. Being heterogeneous in nature it is characterized by complex symptomology of oligomennorhoea, excess of androgens triggering masculine phenotypic appearance and/or multiple follicular ovaries. The etiology of this complex disorder remains somewhat doubtful and the researchers hypothesize multisystem links in the pathogenesis of this disease. In this review, we attempt to present several hypotheses that tend to contribute to the etiology of PCOS. Metabolic inflexibility, aberrant pattern of gonadotropin signaling along with the evolutionary, genetic and environmental factors have been discussed. Considered a lifelong endocrinological implication, no universal treatment is available for PCOS so far however; multiple drug therapy is often advised along with simple life style intervention is mainly advised to manage its cardinal symptoms. Here we aimed to present a summarized view of pathophysiological links of PCOS with potential therapeutic strategies.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:39 |
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| Enthalten in: |
Indian journal of clinical biochemistry : IJCB - 39(2024), 1 vom: 12. Jan., Seite 18-36 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Nisa, Khair Ul [VerfasserIn] |
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| Links: |
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| Themen: |
Environmental toxins |
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| Anmerkungen: |
Date Revised 16.01.2024 published: Print-Electronic Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1007/s12291-023-01130-7 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a Among the premenopausal women, Polycystic Ovary Syndrome (PCOS) is the most prevalent endocrinopathy affecting the reproductive system and metabolic rhythms leading to disrupted menstrual cycle. Being heterogeneous in nature it is characterized by complex symptomology of oligomennorhoea, excess of androgens triggering masculine phenotypic appearance and/or multiple follicular ovaries. The etiology of this complex disorder remains somewhat doubtful and the researchers hypothesize multisystem links in the pathogenesis of this disease. In this review, we attempt to present several hypotheses that tend to contribute to the etiology of PCOS. Metabolic inflexibility, aberrant pattern of gonadotropin signaling along with the evolutionary, genetic and environmental factors have been discussed. Considered a lifelong endocrinological implication, no universal treatment is available for PCOS so far however; multiple drug therapy is often advised along with simple life style intervention is mainly advised to manage its cardinal symptoms. Here we aimed to present a summarized view of pathophysiological links of PCOS with potential therapeutic strategies | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a Environmental toxins | |
| 650 | 4 | |a Etiology | |
| 650 | 4 | |a Genetics | |
| 650 | 4 | |a Neuroendocrine | |
| 650 | 4 | |a PCOS | |
| 650 | 4 | |a Potential therapeutics | |
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| 700 | 1 | |a Mir, Shahnaz Ahmad |e verfasserin |4 aut | |
| 700 | 1 | |a Waza, Ajaz Ahmad |e verfasserin |4 aut | |
| 700 | 1 | |a Ahmad, Mir Bilal |e verfasserin |4 aut | |
| 700 | 1 | |a Ganai, Bashir Ahmad |e verfasserin |4 aut | |
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