Prognostic significance of preoperative exercise tolerance in patients with early-stage lung cancer
Copyright © 2024 The American Association for Thoracic Surgery. Published by Elsevier Inc. All rights reserved..
OBJECTIVE: To investigate the influence of simple preoperative exercise tests as prognostic factors for early-stage lung cancer.
METHODS: This single-institution retrospective study included consecutive patients who underwent pulmonary resection for stage 0 to I lung cancer between April 2017 and December 2019. Before surgery, 7 metabolic equivalents of task in the double Master 2-step test were loaded into the exercise echocardiogram. The relationship between prognosis and exercise stress test results in terms of availability, symptoms, and saturation of percutaneous oxygen was investigated.
RESULTS: This study included 862 patients with pathological stage 0 to I lung cancer. Among the 862 patients, 673 patients (78.1%) who were able to complete 7 metabolic equivalents of task exercise for 3 minutes without assistance were classified into the complete group. The 5-year survival of the complete group was significantly better than that of the incomplete group. Multivariable analysis revealed that age (hazard ratio, 1.06; P = .008), male sex (hazard ratio, 2.23; P = .011), carcinoembryonic antigen level >5 ng/mL (hazard ratio, 2.33; P = .011), and inability to complete 7 metabolic equivalents of task exercise (hazard ratio, 3.90; P < .001) were the prognostic factors. Patients in the older group who had the ability to complete exercise had a better prognosis than those in the younger group without the ability (P = .003).
CONCLUSIONS: Preoperative exercise ability is a prognostic factor for early-stage lung cancer. Patients who can tolerate an exercise load of 7 metabolic equivalents of task, even if they are aged 70 years or older, have a better prognosis than patients younger than age 70 years without exercise tolerance.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2024 |
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| Enthalten in: |
The Journal of thoracic and cardiovascular surgery - (2024) vom: 12. Jan. |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Fukui, Mariko [VerfasserIn] |
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| Links: |
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| Themen: |
5-year survival |
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| Anmerkungen: |
Date Revised 07.02.2024 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.1016/j.jtcvs.2023.12.026 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM367090856 |
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| 500 | |a Date Revised 07.02.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status Publisher | ||
| 520 | |a Copyright © 2024 The American Association for Thoracic Surgery. Published by Elsevier Inc. All rights reserved. | ||
| 520 | |a OBJECTIVE: To investigate the influence of simple preoperative exercise tests as prognostic factors for early-stage lung cancer | ||
| 520 | |a METHODS: This single-institution retrospective study included consecutive patients who underwent pulmonary resection for stage 0 to I lung cancer between April 2017 and December 2019. Before surgery, 7 metabolic equivalents of task in the double Master 2-step test were loaded into the exercise echocardiogram. The relationship between prognosis and exercise stress test results in terms of availability, symptoms, and saturation of percutaneous oxygen was investigated | ||
| 520 | |a RESULTS: This study included 862 patients with pathological stage 0 to I lung cancer. Among the 862 patients, 673 patients (78.1%) who were able to complete 7 metabolic equivalents of task exercise for 3 minutes without assistance were classified into the complete group. The 5-year survival of the complete group was significantly better than that of the incomplete group. Multivariable analysis revealed that age (hazard ratio, 1.06; P = .008), male sex (hazard ratio, 2.23; P = .011), carcinoembryonic antigen level >5 ng/mL (hazard ratio, 2.33; P = .011), and inability to complete 7 metabolic equivalents of task exercise (hazard ratio, 3.90; P < .001) were the prognostic factors. Patients in the older group who had the ability to complete exercise had a better prognosis than those in the younger group without the ability (P = .003) | ||
| 520 | |a CONCLUSIONS: Preoperative exercise ability is a prognostic factor for early-stage lung cancer. Patients who can tolerate an exercise load of 7 metabolic equivalents of task, even if they are aged 70 years or older, have a better prognosis than patients younger than age 70 years without exercise tolerance | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a 5-year survival | |
| 650 | 4 | |a Master 2-step test | |
| 650 | 4 | |a exercise test | |
| 650 | 4 | |a pulmonary resection | |
| 650 | 4 | |a surgery | |
| 700 | 1 | |a Matsunaga, Takeshi |e verfasserin |4 aut | |
| 700 | 1 | |a Hattori, Aritoshi |e verfasserin |4 aut | |
| 700 | 1 | |a Takamochi, Kazuya |e verfasserin |4 aut | |
| 700 | 1 | |a Tomita, Hisashi |e verfasserin |4 aut | |
| 700 | 1 | |a Nojiri, Shuko |e verfasserin |4 aut | |
| 700 | 1 | |a Suzuki, Kenji |e verfasserin |4 aut | |
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