Exploring the effect of butyric acid, a metabolite from periodontopathic bacteria, on primary human melanocytes : An in vitro study
Copyright © 2024 Japanese Association for Oral Biology. Published by Elsevier B.V. All rights reserved..
Effects of butyric acid, a bacterial metabolite implicated in periodontitis progression, have never been examined on oral melanocytes. Herein, primary human epidermal melanocytes were used as a model for oral melanocytes. Results show the adverse effects of butyric acid (sodium butyrate; NaB) on them, which comprise marked cytotoxicity at higher concentrations (>1 mM) and robust differentiation at lower nontoxic concentrations. NaB did not alter MITF protein levels; however, it stimulated tyrosinase protein synthesis and inhibited tyrosinase activity, with no changes in cellular melanin. NaB did not affect oxidative stress, although it induced significant levels of the pro-inflammatory cytokine IL-6.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2024 |
|---|---|
| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:66 |
|---|---|
| Enthalten in: |
Journal of oral biosciences - 66(2024), 1 vom: 07. März, Seite 253-259 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Goenka, Shilpi [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
107-92-6 |
|---|
| Anmerkungen: |
Date Completed 08.03.2024 Date Revised 08.03.2024 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1016/j.job.2024.01.002 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM367063689 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM367063689 | ||
| 003 | DE-627 | ||
| 005 | 20240308232327.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240114s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.job.2024.01.002 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1320.xml |
| 035 | |a (DE-627)NLM367063689 | ||
| 035 | |a (NLM)38215819 | ||
| 035 | |a (PII)S1349-0079(24)00002-1 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Goenka, Shilpi |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Exploring the effect of butyric acid, a metabolite from periodontopathic bacteria, on primary human melanocytes |b An in vitro study |
| 264 | 1 | |c 2024 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 08.03.2024 | ||
| 500 | |a Date Revised 08.03.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2024 Japanese Association for Oral Biology. Published by Elsevier B.V. All rights reserved. | ||
| 520 | |a Effects of butyric acid, a bacterial metabolite implicated in periodontitis progression, have never been examined on oral melanocytes. Herein, primary human epidermal melanocytes were used as a model for oral melanocytes. Results show the adverse effects of butyric acid (sodium butyrate; NaB) on them, which comprise marked cytotoxicity at higher concentrations (>1 mM) and robust differentiation at lower nontoxic concentrations. NaB did not alter MITF protein levels; however, it stimulated tyrosinase protein synthesis and inhibited tyrosinase activity, with no changes in cellular melanin. NaB did not affect oxidative stress, although it induced significant levels of the pro-inflammatory cytokine IL-6 | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Butyrate | |
| 650 | 4 | |a Gingiva | |
| 650 | 4 | |a IL-6 | |
| 650 | 4 | |a Melanogenesis | |
| 650 | 4 | |a Primary human melanocytes | |
| 650 | 7 | |a Butyric Acid |2 NLM | |
| 650 | 7 | |a 107-92-6 |2 NLM | |
| 650 | 7 | |a Monophenol Monooxygenase |2 NLM | |
| 650 | 7 | |a EC 1.14.18.1 |2 NLM | |
| 650 | 7 | |a Melanins |2 NLM | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of oral biosciences |d 2008 |g 66(2024), 1 vom: 07. März, Seite 253-259 |w (DE-627)NLM194012034 |x 1880-3865 |7 nnns |
| 773 | 1 | 8 | |g volume:66 |g year:2024 |g number:1 |g day:07 |g month:03 |g pages:253-259 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.job.2024.01.002 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 66 |j 2024 |e 1 |b 07 |c 03 |h 253-259 | ||