The human microbiome and benign prostatic hyperplasia : Current understandings and clinical implications
Copyright © 2024 Elsevier GmbH. All rights reserved..
The research of the human microbiome in the preceding decade has yielded novel perspectives on human health and diseases. Benign prostatic hyperplasia (BPH) is a common disease in middle-aged and elderly males, which negatively affects the life quality. Existing evidence has indicated that the human microbiome, including urinary, intra-prostate, gut, oral and blood microbiome may exert a significant impact on the natural progression of BPH. The dysbiosis of the microbiome may induce inflammation at either a local or systemic level, thereby affecting the BPH. Moreover, metabolic syndrome (MetS) caused by the microbiome can also be involved in the development of BPH. Additionally, alterations in the microbiome composition during the senility process may serve as another cause of the BPH. Here, we summarize the influence of human microbiome on BPH and explore how the microbiome is linked to BPH through inflammation, MetS, and senility. In addition, we propose promising areas of investigation and discuss the implications for advancing therapeutic approaches.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:281 |
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| Enthalten in: |
Microbiological research - 281(2024) vom: 12. Feb., Seite 127596 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Li, Jiaren [VerfasserIn] |
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| Links: |
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| Themen: |
Benign prostatic hyperplasia |
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| Anmerkungen: |
Date Completed 16.02.2024 Date Revised 16.02.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.micres.2023.127596 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a Copyright © 2024 Elsevier GmbH. All rights reserved. | ||
| 520 | |a The research of the human microbiome in the preceding decade has yielded novel perspectives on human health and diseases. Benign prostatic hyperplasia (BPH) is a common disease in middle-aged and elderly males, which negatively affects the life quality. Existing evidence has indicated that the human microbiome, including urinary, intra-prostate, gut, oral and blood microbiome may exert a significant impact on the natural progression of BPH. The dysbiosis of the microbiome may induce inflammation at either a local or systemic level, thereby affecting the BPH. Moreover, metabolic syndrome (MetS) caused by the microbiome can also be involved in the development of BPH. Additionally, alterations in the microbiome composition during the senility process may serve as another cause of the BPH. Here, we summarize the influence of human microbiome on BPH and explore how the microbiome is linked to BPH through inflammation, MetS, and senility. In addition, we propose promising areas of investigation and discuss the implications for advancing therapeutic approaches | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a Benign prostatic hyperplasia | |
| 650 | 4 | |a Inflammation | |
| 650 | 4 | |a Metabolic syndrome | |
| 650 | 4 | |a Microbiome | |
| 650 | 4 | |a Senility | |
| 700 | 1 | |a Li, Youyou |e verfasserin |4 aut | |
| 700 | 1 | |a Zhou, Liang |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Cheng |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Jiahao |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Dingwen |e verfasserin |4 aut | |
| 700 | 1 | |a Fu, Yunlong |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Yichuan |e verfasserin |4 aut | |
| 700 | 1 | |a Tang, Jin |e verfasserin |4 aut | |
| 700 | 1 | |a Zhou, Lei |e verfasserin |4 aut | |
| 700 | 1 | |a Tan, Shuo |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Long |e verfasserin |4 aut | |
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